On the mechanism of overdrive suppression in the guinea pig sinoatrial node

1990 ◽  
Vol 23 (1) ◽  
pp. 53-67 ◽  
Author(s):  
Yisachar J. Greenberg ◽  
Mario Vassalle
Keyword(s):  
Guinea Pig ◽  
Sinoatrial Node ◽  
Overdrive Suppression

Delayed rectification in single cells isolated from guinea pig sinoatrial node

1992 ◽  
Vol 262 (3) ◽  
pp. H921-H925 ◽  
Author(s):  
J. M. Anumonwo ◽  
L. C. Freeman ◽  
W. M. Kwok ◽  
R. S. Kass
Keyword(s):  
Guinea Pig ◽  
Sinoatrial Node ◽  
Single Cells ◽  
Equilibrium Potential ◽  
Delayed Rectifier ◽  
Experimental Conditions ◽  
Whole Cell ◽  
Voltage Range ◽  
Whole Cell Patch Clamp ◽  
Delayed Rectification

We have studied delayed rectifier K+ currents (IK) in cells isolated from the sinoatrial node (SAN) region of the guinea pig. Using whole cell patch-clamp procedures, we measured the voltage dependence of IK activation and IK kinetics and the IK equilibrium potential in 4.8 mM extracellular K concentration solutions. Experiments were designed to contrast properties of guinea pig SAN IK with those of IK recorded from SAN cells of the rabbit. We find that guinea pig SAN IK differs from IK recorded from single rabbit SAN cells in its activation threshold, and in the absence of inactivation of whole cell currents recorded over a wide voltage range. These results, along with the relative insensitivity of guinea pig SAN IK to E-4031 and lanthanum, suggest that under our experimental conditions, a strongly rectifying IK component (IK,r) is not the major component of delayed rectification in the guinea pig SAN, as it appears to be in SAN cells of the rabbit.

Overdrive excitation in the guinea pig sinoatrial node superfused in high [K+]o

1997 ◽  
Vol 4 (4) ◽  
pp. 179-191 ◽  
Author(s):  
Youyin Choy ◽  
Eugene M. Kim ◽  
Mario Vassalle
Keyword(s):  
Guinea Pig ◽  
Sinoatrial Node ◽  
High K

Remifentanil Has a Minimal Direct Effect on Sinoatrial Node Pacemaker Activity in the Guinea Pig Heart

2013 ◽  
Vol 117 (5) ◽  
pp. 1072-1077 ◽  
Author(s):  
Akiko Kojima ◽  
Yuki Ito ◽  
Hirotoshi Kitagawa ◽  
Hiroshi Matsuura ◽  
Shuichi Nosaka
Keyword(s):  
Guinea Pig ◽  
Direct Effect ◽  
Sinoatrial Node ◽  
Pacemaker Activity ◽  
Guinea Pig Heart
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