Persistent pulmonary hypertension in high-risk congenital diaphragmatic hernia patients: Incidence and vasodilator therapy

1993 ◽  
Vol 28 (11) ◽  
pp. 1463-1465 ◽  
Author(s):  
Albert P. Bos ◽  
Dick Tibboel ◽  
Veronica C.M. Koot ◽  
Frans W.J. Hazebroek ◽  
Jan C. Molenaar
Keyword(s):  
Pulmonary Hypertension ◽  
High Risk ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Persistent Pulmonary Hypertension ◽  
Vasodilator Therapy

Pulmonary Hypertension in Neonates with High-Risk Congenital Diaphragmatic Hernia Does Not Affect Mid-Term Outcome

2011 ◽  
Vol 21 (03) ◽  
pp. 154-158 ◽  
Author(s):  
L. Valfre ◽  
A. Braguglia ◽  
A. Conforti ◽  
F. Morini ◽  
A. Trucchi ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
High Risk ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Term Outcome

scholarly journals International recommendations on neonatal management with congenital diaphragmatic hernia: literature review

2021 ◽  
pp. 51-60
Author(s):  
А.G. Babintseva ◽  
◽  
Yu.D. Godovanets ◽  
Yu.Yu. Khodzinska ◽  
N.O. Popeliuk ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Large Scale ◽  
Level Of Evidence ◽  
Vasodilator Therapy ◽  
Membrane Oxygenation ◽  
Pulmonary Vasodilator ◽  
Extracorporal Membrane Oxygenation ◽  
Ultrasound Diagnostics

Congenital diaphragmatic hernia (CDH) is a defect of diaphragm development which is characterized by herniation of the abdominal content into the chest resulting in pulmonary hypoplasia and pulmonary hypertension of various degrees. Mortality and sickness rates among survived children with this pathology remain high all over the world. Prenatal diagnostics of high quality will help to find neonates with severe CDH and promote mobilization of human and material resources for optimal management at the tertiary level of giving medical aid. Attention of specialists in prenatal ultrasound diagnostics should be drawn to the necessity of measuring observed/expected lung(to(head ratio and location of the liver in fetus. Optimal treatment of neonates during preoperative period is focused on mild ventilation, avoidance of oxygen toxicity, baro/volutrauma of a hypoplastic lung and cardiac support. Administration of pulmonary vasodilator therapy including inhaled nitric oxide and extracorporal membrane oxygenation is pathogenetically substantiated for patients with pulmonary hypertension, and surgical correction should be delayed till stabilization of patient's condition. Echocardiography is a critically important diagnostic method. It enables to determine severity of pulmonary hypertension and myocardial functional disorders, to find targeted systemic methods of treatment that improve hemodynamic function or decrease pulmonary vascular resistance. Considering an insufficient level of evidence of the existing international recommendations, large(scale multi(center randomized studies on investigation of the best methods to prevent, diagnose and treat neonates with CDH are essential. No conflict of interest was declared by the authors. Key words: congenital diaphragmatic hernia; neonate; lung-to-head ratio; pulmonary hypertension; extracorporal membrane oxygenation.

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