Large scale preparation of (2S,3S)-N-Boc-3-amino-1,2-epoxy-4-phenylbutane: A key building block for HIV-protease inhibitors

1995 ◽  
Vol 36 (19) ◽  
pp. 3317-3320 ◽  
Author(s):  
Pierre L. Beaulieu ◽  
Dominik Wernic ◽  
Jean-Simon Duceppe ◽  
Yvan Guindon
Keyword(s):  
Protease Inhibitors ◽  
Building Block ◽  
Large Scale ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors ◽  
Large Scale Preparation ◽  
Scale Preparation

A convenient synthesis of 1-(S)-[1′-(S)-(t-butyloxycarbonylamino)-2′-phenylethyl]oxirane. A useful building block in the synthesis of HIV protease inhibitors

1997 ◽  
Vol 38 (19) ◽  
pp. 3483-3486 ◽  
Author(s):  
Jonas Brånalt ◽  
Ingemar Kvarnström ◽  
Björn Classon ◽  
Bertil Samuelsson ◽  
Ulrika Nillroth ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Building Block ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors ◽  
Convenient Synthesis

Purification of the Antihemophilic Factor by Gel Filtration on Agarose

1969 ◽  
Vol 22 (03) ◽  
pp. 577-583 ◽  
Author(s):  
M.M.P Paulssen ◽  
A.C.M.G.B Wouterlood ◽  
H.L.M.A Scheffers
Keyword(s):  
Factor Viii ◽  
Plasma Proteins ◽  
Large Scale ◽  
Gel Filtration ◽  
Large Scale Preparation ◽  
Scale Preparation ◽  
Antihemophilic Factor

SummaryFactor VIII can be isolated from plasma proteins, including fibrinogen by chromatography on agarose. The best results were obtained with Sepharose 6B. Large scale preparation is also possible when cryoprecipitate is separated by chromatography. In most fractions containing factor VIII a turbidity is observed which may be due to the presence of chylomicrons.The purified factor VIII was active in vivo as well as in vitro.

Determining and Overcoming Resistance to HIV Protease Inhibitors

2004 ◽  
Vol 4 (2) ◽  
pp. 137-152 ◽  
Author(s):  
Jana Prejdova ◽  
Milan Soucek ◽  
Jan Konvalinka
Keyword(s):  
Protease Inhibitors ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors
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