Synthesis and processing of glycoproteins of Varicella-Zoster virus (VZV) as studied with monoclonal antibodies to VZV antigens

Virology ◽  
1983 ◽  
Vol 129 (2) ◽  
pp. 357-368 ◽  
Author(s):  
Toshiomi Okuno ◽  
Koichi Yamanishi ◽  
Kimiyasu Shiraki ◽  
Michiaki Takahashi
Keyword(s):  
Monoclonal Antibodies ◽  
Varicella Zoster Virus ◽  
Varicella Zoster ◽  
Synthesis And Processing

scholarly journals Varicella-zoster virus gH:gL contains a structure reactive with the anti-human gamma chain of IgG near the glycosylation site

2001 ◽  
Vol 82 (2) ◽  
pp. 331-334 ◽  
Author(s):  
Tomonori Yokoyama ◽  
Satoko Ayabe ◽  
Huminori Miyagi ◽  
Toru Sugano ◽  
Akira Otsu ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Varicella Zoster Virus ◽  
Immune Evasion ◽  
Human Monoclonal Antibody ◽  
Glycosylation Site ◽  
Elisa Assay ◽  
Gamma Chain ◽  
Varicella Zoster ◽  
Infected Cells

Varicella-zoster virus (VZV) glycoproteins were purified from infected cells using monoclonal antibodies and gH:gL was found to react with antibodies to the γ chain of human IgG (h-IgG), whereas gE:gI and gB did not. When gH:gL was captured by concanavalin A, it lost reactivity with the anti-h-IgG γ chain (anti-h-γ-IgG). gH:gL reacted with anti-h-γ-IgG in an ELISA assay and gave a K d value of 2·16×10−7 M in a BIAcore assay. The K d value of the human monoclonal antibody to gH (TI-57) used for the purification of gH:gL was 4·45×10−10 M. Virus pretreated with anti-h-IgG was five times more resistant to neutralization with TI-57. Although the nature of the binding was not clear, gH:gL bound to anti-h-γ-IgG. If this interaction results from immunological similarity between gH:gL and h-IgG, it may cause immune evasion in the pathogenesis of VZV infection.

scholarly journals Recognition of similar epitopes on varicella-zoster virus gpI and gpIV by monoclonal antibodies.

1988 ◽  
Vol 62 (8) ◽  
pp. 2544-2551 ◽  
Author(s):  
A Vafai ◽  
Z Wroblewska ◽  
R Mahalingam ◽  
G Cabirac ◽  
M Wellish ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Varicella Zoster Virus ◽  
Varicella Zoster

Human Monoclonal Antibodies Neutralizing Varicella-Zoster Virus

1985 ◽  
Vol 152 (2) ◽  
pp. 280-285 ◽  
Author(s):  
S. K. H. Foung ◽  
S. Perkins ◽  
C. Koropchak ◽  
D. M. Fishwild ◽  
A. E. Wittek ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Varicella Zoster Virus ◽  
Human Monoclonal Antibodies ◽  
Varicella Zoster

Rapid detection of varicella-zoster virus in clinical specimens using monoclonal antibodies on shell vials and smears

1989 ◽  
Vol 28 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Janneke J. M. Meulenberg ◽  
Jurjen Schirm ◽  
Geke W. Pastoor ◽  
F. Peter Schröder ◽  
Pieter C. Voorst Van Vader
Keyword(s):  
Monoclonal Antibodies ◽  
Varicella Zoster Virus ◽  
Rapid Detection ◽  
Clinical Specimens ◽  
Varicella Zoster
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