Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro

Cell ◽  
1987 ◽  
Vol 49 (1) ◽  
pp. 121-129 ◽  
Author(s):  
André Weydert ◽  
Paul Barton ◽  
A.John Harris ◽  
Christian Pinset ◽  
Margaret Buckingham
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Developmental Pattern ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene ◽  
Skeletal Myosin ◽  
Gene Transcripts

Molecular characterization of a developmentally regulated porcine skeletal myosin heavy chain gene and its 5′ regulatory region

1995 ◽  
Vol 108 (4) ◽  
pp. 1779-1789 ◽  
Author(s):  
K.C. Chang ◽  
K. Fernandes ◽  
M.J. Dauncey
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Transcriptional Start Site ◽  
Regulatory Region ◽  
Chain Gene ◽  
Specific Expression ◽  
Slow Fibre ◽  
Skeletal Myosin

Members of the myosin heavy chain (MyHC) gene family show developmental stage- and spatial-specificity of expression. We report on the characterization and identification of a porcine skeletal fast MyHC gene, including its corresponding 5′ end cDNA and 5′ regulatory region. This MyHC isoform was found exclusively in skeletal muscles from about the last quarter of gestation through to adulthood. Expression of this isoform was higher postnatally and its spatial distribution resembled a rosette cluster; each with a ring of fast fibres surrounding a central slow fibre. This rosette pattern was absent in the adult diaphragm but about 20% of the fibres continued to express this MyHC isoform. Further in vivo expression studies, in a variety of morphologically and functionally diverse muscles, showed that this particular skeletal MyHC isoform was expressed in fast oxidative-glycolytic fibres, suggesting that it was the equivalent of the fast IIA isoform. Two domains in the upstream regulatory region were found to confer differentiation-specific expression on C2 myotubes (−1007 to -828 and -455 to -101), based on in vitro transient expression assays using the chloramphenicol acetyltransferase (CAT) reporter gene. Interestingly, for high levels of CAT expression to occur, a 3′ region, extending from the transcriptional start site to part. of intron 2, must be present in all the DNA constructs used.

scholarly journals Organization of the human skeletal myosin heavy chain gene cluster.

1992 ◽  
Vol 89 (24) ◽  
pp. 12078-12082 ◽  
Author(s):  
S. J. Yoon ◽  
S. H. Seiler ◽  
R. Kucherlapati ◽  
L. Leinwand
Keyword(s):  
Myosin Heavy Chain ◽  
Gene Cluster ◽  
Heavy Chain ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene ◽  
Skeletal Myosin

IN VIVO GENE REGULATION OF THE ?? MYOSIN HEAVY CHAIN GENE IN RODENT HEART

1998 ◽  
Vol 30 (Supplement) ◽  
pp. 143
Author(s):  
C. E Wright ◽  
F. Haddad ◽  
P. W. Bodell ◽  
K. M. Baldwin
Keyword(s):  
Gene Regulation ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene

scholarly journals Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved

1999 ◽  
Vol 96 (6) ◽  
pp. 2958-2963 ◽  
Author(s):  
A. Weiss ◽  
D. McDonough ◽  
B. Wertman ◽  
L. Acakpo-Satchivi ◽  
K. Montgomery ◽  
...  
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Gene Clusters ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene ◽  
Skeletal Myosin ◽  
Human And Mouse

The complete genomic sequence of the carp fast skeletal myosin heavy chain gene

Gene ◽  
2005 ◽  
Vol 349 ◽  
pp. 143-151 ◽  
Author(s):  
Maiko Muramatsu-Uno ◽  
Kiyoshi Kikuchi ◽  
Hiroaki Suetake ◽  
Daisuke Ikeda ◽  
Shugo Watabe
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Genomic Sequence ◽  
Chain Gene ◽  
Complete Genomic Sequence ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene ◽  
Skeletal Myosin ◽  
Complete Genomic

scholarly journals In vivo analysis of the murine beta-myosin heavy chain gene promoter.

1993 ◽  
Vol 268 (7) ◽  
pp. 5332-5338
Author(s):  
H. Rindt ◽  
J. Gulick ◽  
S. Knotts ◽  
J. Neumann ◽  
J. Robbins
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Gene Promoter ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene ◽  
In Vivo Analysis
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