Clastogenic effect of the plant alkaloid ellipticine on bone marrow cells of Wistar rats and on human peripheral blood lymphocytes

1988 ◽  
Vol 199 (1) ◽  
pp. 11-19
Author(s):  
Elza T. Sakamoto-Hojo ◽  
Catarina S. Takahashi ◽  
Iris Ferrari ◽  
M. Motidome
Keyword(s):  
Bone Marrow ◽  
Peripheral Blood ◽  
Wistar Rats ◽  
Bone Marrow Cells ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Human Peripheral Blood Lymphocytes ◽  
Clastogenic Effect ◽  
Marrow Cells

scholarly journals Potential chemoprotective effects of green propolis, L-lysine and celecoxib on bone marrow cells and peripheral blood lymphocytes of Wistar rats subjected to bladder chemical carcinogenesis

2014 ◽  
Vol 29 (7) ◽  
pp. 423-428 ◽  
Author(s):  
Conceição Aparecida Dornelas ◽  
Bruno Coelho Cavalcanti ◽  
Hemerson Iury Ferreira Magalhães ◽  
Francisco Vagnaldo Fechine Jamacaru ◽  
Francisco Nelson Nóbrega Furtado ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Peripheral Blood ◽  
Wistar Rats ◽  
Bone Marrow Cells ◽  
Chemical Carcinogenesis ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Marrow Cells

scholarly journals Assessment of Potential Clastogenic Effect of the Insecticide Mospilan® 20SP in Human Peripheral Blood Lymphocytes After in Vitro Exposure

2019 ◽  
Vol 63 (2) ◽  
pp. 21-24
Author(s):  
K. Ničová ◽  
V. Schwarzbacherová ◽  
M. Galdíková ◽  
B. Holečková
Keyword(s):  
Peripheral Blood ◽  
Chromosome Aberrations ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Human Peripheral Blood Lymphocytes ◽  
Neonicotinoid Insecticide ◽  
Clastogenic Effect ◽  
Chromosome Aberration Test

Abstract Acetamiprid, that is known as the commercial formulation Mospilan® 20SP is the part of the neonicotinoid insecticide group and is widely used against various pests. In our study we assessed the potential clastogenic effects of Mospilan® in human peripheral blood lymphocytes in vitro using a chromosome aberration test. The lymphocytes were treated with acetamiprid in the concentration range of 5, 10, 25 and 50 µg.ml−1 for 24 and 48 h. After 24 h exposure, the insecticide induced statistically significant higher levels of chromosome aberrations from the concentration of 10 µg.ml−1 (P < 0.05 and P < 0.001) and a significant decrease in mitotic index (MI) at the concentrations of 25 and 50 µg.ml−1 (P < 0.05 and P < 0.01), respectively. After a 48 h exposure, we found a dose dependent increase in the percentage of chromosome aberrations at all concentrations (P < 0.05; P < 0.01 and P < 0.001) and a decrease in MI at concentrations of 25 and 50 µg.ml−1 (P < 0.05 and P < 0.01). Our results indicated that neonicotinoid insecticide formulations containing acetamiprid may have potential cytotoxic and genotoxic effects.

scholarly journals Chromosome aberrations and micronuclei in bone marrow cells and peripheral blood lymphocytes in humans exposed to ethylene oxide

Hereditas ◽  
2008 ◽  
Vol 98 (1) ◽  
pp. 105-113 ◽  
Author(s):  
BENKT HÖGSTEDT ◽  
BO GULLBERG ◽  
KARIN HEDNER ◽  
ANNE-MARIE KOLNIG ◽  
FELIX MITELMAN ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Ethylene Oxide ◽  
Peripheral Blood ◽  
Chromosome Aberrations ◽  
Bone Marrow Cells ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Marrow Cells

Transfer of the ADA Gene into Bone Marrow Cells and Peripheral Blood Lymphocytes for the Treatment of Patients Affected by ADA-Deficient SCID

1993 ◽  
Vol 4 (4) ◽  
pp. 513-520 ◽  
Author(s):  
Claudio Bordignon ◽  
Fulvio Mavilio ◽  
Giuliana Ferrari ◽  
Paolo Servida ◽  
Alberto G. Ugazio ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Peripheral Blood ◽  
Bone Marrow Cells ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Marrow Cells
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