Genotoxic effects of deltamethrin in the mouse bone marrow micronucleus assay

1995 ◽  
Vol 346 (4) ◽  
pp. 203-206 ◽  
Author(s):  
G. Gandhi ◽  
J.B. Chowdhury ◽  
P.K. Sareen ◽  
V.P.S. Dhillon
Keyword(s):  
Bone Marrow ◽  
Micronucleus Assay ◽  
Mouse Bone Marrow ◽  
Genotoxic Effects ◽  
Bone Marrow Micronucleus

scholarly journals Reduction of doxorubicin-induced genotoxicity by Handroanthus impetiginosus in mouse bone marrow revealed by micronucleus assay

2017 ◽  
Vol 78 (1) ◽  
pp. 1-12
Author(s):  
M. F. G. Boriollo ◽  
T. A. Silva ◽  
M. F. Rodrigues-Netto ◽  
J. J. Silva ◽  
M. B. Marques ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Micronucleus Assay ◽  
Chemical Compounds ◽  
Chemotherapeutic Agents ◽  
Mouse Bone Marrow ◽  
Genotoxic Effects ◽  
Dose Time ◽  
Polychromatic Erythrocytes ◽  
And Gender ◽  
Handroanthus Impetiginosus

Abstract Handroanthus impetiginosus has long been used in traditional medicine and various studies have determined the presence of bioactive chemical compounds and potential phytotherapeutics. In this study, the genotoxicity of the lyophilized tincture of H. impetiginosus bark (THI) was evaluated in mouse bone marrow using micronucleus assays. The interaction between THI and genotoxic effects induced by the chemotherapeutic agent, doxorubicin (DXR), was also analyzed. Experimental groups were evaluated 24 to 48 h after treatment with N-nitroso-N-ethylurea (NEU; 50 mg/kg), DXR (5 mg/kg), sodium chloride (NaCl; 150 mM), and THI (0.5-2 g/kg). Antigenotoxic assays were carried out using THI (0.5 g/kg) in combination with NEU or DXR. Analysis of the micronucleated polychromatic erythrocytes (MNPCEs) indicated no significant differences between treatment doses of THI (0.5-2 g/kg) and NaCl. Polychromatic erythrocyte (PCE) to normochromatic erythrocyte (NCE) ratios did not indicate any statistical differences between DXR and THI or NaCl, but there were differences between THI and NaCl. A significant reduction in MNPCEs and PCE/NCE ratios was observed when THI was administered in combination with DXR. This study suggested the absence of THI genotoxicity that was dose-, time-, and gender-independent and the presence of moderate systemic toxicity that was dose-independent, but time- and gender-dependent. The combination of THI and DXR also suggested antigenotoxic effects, indicating that THI reduced genotoxic effects induced by chemotherapeutic agents.

A simplified protocol for the mouse bone marrow micronucleus assay

1988 ◽  
Vol 8 (2) ◽  
pp. 141-144 ◽  
Author(s):  
Michael L. Garriott ◽  
Charles E. Piper ◽  
Andrew J. Kokkino
Keyword(s):  
Bone Marrow ◽  
Micronucleus Assay ◽  
Mouse Bone Marrow ◽  
Bone Marrow Micronucleus
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