Evidence for a direct effect of somatostatin on cardiac pace-maker cells of guinea-pig

(1) The young of parents both of which have been injected with an immunising mixture of diphtheria toxin and antitoxin, show immunity of the same order as that of young from similarly treated mothers and normal fathers.(2) The injection of certain foreign substances into a female guinea-pig appears to have a direct effect on the offspring in diminishing their resistance to diphtheria toxin, shown equally well by the young of mothers injected, (a) before the attainment of sexual maturity, (b) during pregnancy, and (c) after birth during the period of lactation.(3) A single injection of diphtheria toxin may give rise to a condition of active immunity (as tested by the resistance of the young) in guinea-pigs possessing hereditarily transmitted passive immunity. Should this injection of toxin give rise to great constitutional disturbance, the young may show lowered resistance, whereas, if it give rise to but slight constitutional disturbance, the young show a high degree of immunity. These effects appear to be accentuated if similar injections are repeated in the next generation.

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Direct effect of histamine on the production of adrenocortical hormone by guinea-pig adrenal cells.

The Japanese Journal of Physiology ◽

10.2170/jjphysiol.31.605 ◽

1981 ◽

Vol 31 (4) ◽

pp. 605-608 ◽

Cited By ~ 3

Author(s):

Itsuro MATSUMOTO ◽

Taeko HIROSE ◽

Tadaomi AIKAWA

Keyword(s):

Guinea Pig ◽

Direct Effect ◽

Adrenal Cells ◽

Adrenocortical Hormone

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Effect of nedocromil sodium on down-regulation of pulmonary β-adrenoceptors

Clinical Science ◽

10.1042/cs0760599 ◽

1989 ◽

Vol 76 (6) ◽

pp. 599-602 ◽

Cited By ~ 6

Author(s):

I. Kioumis ◽

D. Ukena ◽

Peter J. Barnes

Keyword(s):

Guinea Pig ◽

Direct Effect ◽

Binding Capacity ◽

Nedocromil Sodium ◽

Complete Protection ◽

Down Regulation ◽

Therapeutic Relevance ◽

Maximum Binding Capacity ◽

Asthma Drug ◽

Parenchymal Cells

1. We have studied the effect of the anti-inflammatory anti-asthma drug, nedocromil sodium, on down-regulation of pulmonary β-adrenoceptors in guinea-pig lung. 2. Incubation of minced lung with isoprenaline (10 μmol/l) resulted in a reduction in maximum binding capacity of [125I]iodocyanopindolol to lung membranes from 246 ± 4 to 169 ± 6 fmol/mg of protein (mean ± sem, P < 0.01, n = 18). 3. Nedocromil sodium, which had no direct effect on [125I]iodocyanopindolol binding, prevented isoprenaline-induced down-regulation, giving complete protection at a dose of 100 μmol/l. 4. The mechanism of this effect is not certain, but nedocromil sodium may interfere with the internalization of β-adrenoceptors in pulmonary parenchymal cells. This may have some therapeutic relevance.

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Rate Response of Cardiac Pace Maker and Cardiac Rehabilitation

The Japanese Journal of Rehabilitation Medicine ◽

10.2490/jjrmc.56.984 ◽

2019 ◽

Vol 56 (12) ◽

pp. 984-989

Author(s):

Takeshi Mitsuhashi

Keyword(s):

Cardiac Rehabilitation ◽

Cardiac Pace ◽

Pace Maker

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Direct effect of ACTH on renin release in isolated perfused guinea-pig kidneys with adrenal glands

Acta Endocrinologica ◽

10.1530/acta.0.1270142 ◽

1992 ◽

Vol 127 (2) ◽

pp. 142-145 ◽

Cited By ~ 2

Author(s):

Hong-Yi Hu ◽

Osamu Mokuda ◽

Yoshikazu Sakamoto ◽

Naokata Shimizu

Keyword(s):

Guinea Pig ◽

Direct Effect ◽

Adrenal Glands ◽

Renin Activity ◽

Renin Release ◽

Dependent Manner ◽

Aldosterone Secretion ◽

Acth Stimulation ◽

Physiological Concentration ◽

Renin Angiotensin

To investigate the direct effect of corticotropin (ACTH) on the renin-angiotensin-aldosterone system, isolated guinea-pig kidneys with adrenal glands were perfused with various doses of ACTH (0.1–1000 μg/l) and 0.3 mmol/l of dibutyryl cyclic AMP (cAMP) through each cannula inserted into the abdominal aorta and the inferior caval vein. Perfusate renin activity was increased in a dose-dependent manner by the addition of ACTH in a range of 0.1–1000 μg/l, and reached a plateau at 20 min with each dose. The perfusate cAMP level was dose-dependently increased with 10–1000 μg/l of ACTH. Perfusate renin activity was also markedly increased by the addition of dibutyryl cAMP. The same effects of ACTH on renin and cAMP secretions were observed in the kidney perfusion model from which the adrenal glands were excluded. Aldosterone secretion failed to respond to 0.1 μg/l of ACTH, and was increased by higher concentrations (1–1000 μg/1) in the same experiments. These results demonstrate that ACTH has a direct effect on renal renin release in a physiological concentration (0.1 μg/l), and that the action of ACTH is probably mediated by cAMP. The sensitivity of renin release to ACTH stimulation is no less than that of aldosterone secretion during ACTH infusion, so it is possible that ACTH is an important stimulator of the renin-angiotensin system.

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