Muscimol-induced reduction of GABAA receptor α1-subunit mRNA in primary cultured cerebral cortical neurons

1992 ◽  
Vol 15 (3-4) ◽  
pp. 327-331 ◽  
Author(s):  
Masaaki Hirouchi ◽  
Seitaro Ohkuma ◽  
Kinya Kuriyama
Keyword(s):  
Gabaa Receptor ◽  
Cortical Neurons ◽  
Subunit Mrna ◽  
Cerebral Cortical Neurons ◽  
Α1 Subunit

GABAA Receptor β3 Subunit Deletion Decreases α2/3 Subunits and IPSC Duration

2003 ◽  
Vol 89 (1) ◽  
pp. 128-134 ◽  
Author(s):  
Epolia Ramadan ◽  
Zhanyan Fu ◽  
Gabriele Losi ◽  
Gregg E. Homanics ◽  
Joseph H. Neale ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Cortical Neurons ◽  
Behavioral Deficits ◽  
Inhibitory Postsynaptic Currents ◽  
Postsynaptic Currents ◽  
Surface Staining ◽  
Α1 Subunit

Deletion of the β3 subunit of the GABAA receptor produces severe behavioral deficits and epilepsy. GABAA receptor-mediated miniature inhibitory postsynaptic currents (mIPSCs) in cortical neurons in cultures from β3 −/− mice were significantly faster than those in β3 +/+ mice and were more prolonged by zolpidem. Surface staining revealed that the number of β2/3, α2, and α3 (but not of α1) subunit-expressing neurons and the intensity of subunit clusters were significantly reduced in β3 −/− mice. Transfection of β3 −/− neurons with β3 cDNA restored β2/3, α2, and α3 subunits immunostaining and slowed mIPSCs decay. We show that the deletion of the β3 subunit causes the loss of a subset of GABAA receptors with α2 and α3 subunits while leaving a receptor population containing predominantly α1 subunit with fast spontaneous IPSC decay and increased zolpidem sensitivity.

scholarly journals Expression of GABAA receptor α1 subunit mRNA and protein in rat neocortex following photothrombotic infarction

2008 ◽  
Vol 1210 ◽  
pp. 29-38 ◽  
Author(s):  
Elena A. Kharlamov ◽  
Kathy L. Downey ◽  
Peter I. Jukkola ◽  
Dennis R. Grayson ◽  
Kevin M. Kelly
Keyword(s):  
Gabaa Receptor ◽  
Subunit Mrna ◽  
Rat Neocortex ◽  
Α1 Subunit

Localization of GABAA-receptor α1 subunit mRNA-containing neurons in the lower brainstem of the rat

1990 ◽  
Vol 7 (4) ◽  
pp. 335-345 ◽  
Author(s):  
T. Hironaka ◽  
Y. Morita ◽  
S. Hagihira ◽  
E. Tateno ◽  
H. Kita ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Subunit Mrna ◽  
Α1 Subunit

Ethanol enhances synaptically evoked GABAA receptor-mediated responses in cerebral cortical neurons in rat brain slices

1992 ◽  
Vol 595 (2) ◽  
pp. 220-227 ◽  
Author(s):  
William R. Proctor ◽  
Brandi L. Soldo ◽  
Andrea M. Allan ◽  
Thomas V. Dunwiddie
Keyword(s):  
Rat Brain ◽  
Gabaa Receptor ◽  
Cortical Neurons ◽  
Brain Slices ◽  
Cerebral Cortical Neurons

scholarly journals PKCγ is required for ethanol-induced increases in GABAA receptor α4 subunit expression in cultured cerebral cortical neurons

2011 ◽  
Vol 116 (4) ◽  
pp. 554-563 ◽  
Author(s):  
David F. Werner ◽  
Sandeep Kumar ◽  
Hugh E. Criswell ◽  
Asha Suryanarayanan ◽  
J. Alex Fetzer ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Cortical Neurons ◽  
Cerebral Cortical Neurons ◽  
Subunit Expression

GABAA receptor stimulation enhances NMDA-induced Ca2+ influx in mouse cerebral cortical neurons in primary culture

1994 ◽  
Vol 27 (1) ◽  
pp. 145-151 ◽  
Author(s):  
Seitaro Ohkuma ◽  
Da-Zhi Chen ◽  
Masashi Katsura ◽  
Shi-Hu Chen ◽  
Kinya Kuriyama
Keyword(s):  
Primary Culture ◽  
Gabaa Receptor ◽  
Cortical Neurons ◽  
Receptor Stimulation ◽  
Cerebral Cortical Neurons
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