scholarly journals Expression of GABAA receptor α1 subunit mRNA and protein in rat neocortex following photothrombotic infarction

2008 ◽  
Vol 1210 ◽  
pp. 29-38 ◽  
Author(s):  
Elena A. Kharlamov ◽  
Kathy L. Downey ◽  
Peter I. Jukkola ◽  
Dennis R. Grayson ◽  
Kevin M. Kelly
Keyword(s):  
Gabaa Receptor ◽  
Subunit Mrna ◽  
Rat Neocortex ◽  
Α1 Subunit

Localization of GABAA-receptor α1 subunit mRNA-containing neurons in the lower brainstem of the rat

1990 ◽  
Vol 7 (4) ◽  
pp. 335-345 ◽  
Author(s):  
T. Hironaka ◽  
Y. Morita ◽  
S. Hagihira ◽  
E. Tateno ◽  
H. Kita ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Subunit Mrna ◽  
Α1 Subunit

Morphine withdrawal increases expression of GABAA receptor ε subunit mRNA in locus coeruleus neurons

Neuroreport ◽  
2001 ◽  
Vol 12 (13) ◽  
pp. 2981-2985 ◽  
Author(s):  
Anu T. Heikkilä ◽  
Oxana Echenko ◽  
Mikko Uusi-Oukari ◽  
Saku T. Sinkkonen ◽  
Esa R. Korpi
Keyword(s):  
Locus Coeruleus ◽  
Gabaa Receptor ◽  
Morphine Withdrawal ◽  
Subunit Mrna

Developmental expression of the α6 GABAA receptor subunit mRNA occurs only after cerebellar granule cell migration

1993 ◽  
Vol 75 (1) ◽  
pp. 91-103 ◽  
Author(s):  
Tian Zheng ◽  
Maria-Rita Santi ◽  
Patrizia Bovolin ◽  
Lionel N.J-L. Marlier ◽  
Dennis R. Grayson
Keyword(s):  
Cell Migration ◽  
Gabaa Receptor ◽  
Granule Cell ◽  
Cerebellar Granule Cell ◽  
Developmental Expression ◽  
Receptor Subunit ◽  
Cerebellar Granule ◽  
Subunit Mrna

GABAA Receptor β3 Subunit Deletion Decreases α2/3 Subunits and IPSC Duration

2003 ◽  
Vol 89 (1) ◽  
pp. 128-134 ◽  
Author(s):  
Epolia Ramadan ◽  
Zhanyan Fu ◽  
Gabriele Losi ◽  
Gregg E. Homanics ◽  
Joseph H. Neale ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Cortical Neurons ◽  
Behavioral Deficits ◽  
Inhibitory Postsynaptic Currents ◽  
Postsynaptic Currents ◽  
Surface Staining ◽  
Α1 Subunit

Deletion of the β3 subunit of the GABAA receptor produces severe behavioral deficits and epilepsy. GABAA receptor-mediated miniature inhibitory postsynaptic currents (mIPSCs) in cortical neurons in cultures from β3 −/− mice were significantly faster than those in β3 +/+ mice and were more prolonged by zolpidem. Surface staining revealed that the number of β2/3, α2, and α3 (but not of α1) subunit-expressing neurons and the intensity of subunit clusters were significantly reduced in β3 −/− mice. Transfection of β3 −/− neurons with β3 cDNA restored β2/3, α2, and α3 subunits immunostaining and slowed mIPSCs decay. We show that the deletion of the β3 subunit causes the loss of a subset of GABAA receptors with α2 and α3 subunits while leaving a receptor population containing predominantly α1 subunit with fast spontaneous IPSC decay and increased zolpidem sensitivity.

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