Radial maze performance, open-field and elevated plus-maze behaviors in Fyn-kinase deficient mice: Further evidence for increased fearfulness

1996 ◽  
Vol 37 (1-2) ◽  
pp. 145-150 ◽  
Author(s):  
Tsuyoshi Miyakawa ◽  
Takeshi Yagi ◽  
Akira Kagiyama ◽  
Hiroaki Niki
Keyword(s):  
Open Field ◽  
Radial Maze ◽  
Elevated Plus Maze ◽  
Maze Performance ◽  
Fyn Kinase ◽  
Plus Maze ◽  
Radial Maze Performance ◽  
Deficient Mice

Progesterone withdrawal effects in the open field test can be predicted by elevated plus maze performance

2006 ◽  
Vol 50 (2) ◽  
pp. 208-215 ◽  
Author(s):  
Magnus Löfgren ◽  
Inga-Maj Johansson ◽  
Bengt Meyerson ◽  
Per Lundgren ◽  
Torbjörn Bäckström
Keyword(s):  
Open Field ◽  
Field Test ◽  
Elevated Plus Maze ◽  
Open Field Test ◽  
Maze Performance ◽  
Plus Maze ◽  
Withdrawal Effects

scholarly journals Effect of KW-6055 on spatial cognitive disruption in 8-arm radial maze performance in rats

1989 ◽  
Vol 49 ◽  
pp. 267
Author(s):  
Katsunori Iwasaki ◽  
Yoshiaki Matsumoto ◽  
Michihiro Fujiwara
Keyword(s):  
Radial Maze ◽  
Maze Performance ◽  
Radial Maze Performance

Effects of histamine on MK-801-induced memory deficits in radial maze performance in rats

1999 ◽  
Vol 839 (1) ◽  
pp. 186-189 ◽  
Author(s):  
Zhong Chen ◽  
Quie Zhao ◽  
Yukio Sugimoto ◽  
Yoko Fujii ◽  
Chiaki Kamei
Keyword(s):  
Radial Maze ◽  
Memory Deficits ◽  
Maze Performance ◽  
Mk 801 ◽  
Radial Maze Performance

scholarly journals Participation ofGABAAChloride Channels in the Anxiolytic-Like Effects of a Fatty Acid Mixture

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Juan Francisco Rodríguez-Landa ◽  
Rosa Isela García-Ríos ◽  
Jonathan Cueto-Escobedo ◽  
Blandina Bernal-Morales ◽  
Carlos M. Contreras
Keyword(s):  
Open Field ◽  
Field Test ◽  
Chloride Channels ◽  
Wistar Rats ◽  
Elevated Plus Maze ◽  
Open Field Test ◽  
Acid Mixture ◽  
Plus Maze ◽  
Gaba Binding ◽  
Defensive Burying

Human amniotic fluid and a mixture of eight fatty acids (FAT-M) identified in this maternal fluid (C12:0, lauric acid, 0.9 μg%; C14:0, myristic acid, 6.9 μg%; C16:0, palmitic acid, 35.3 μg%; C16:1, palmitoleic acid, 16.4 μg%; C18:0, stearic acid, 8.5 μg%; C18:1cis, oleic acid, 18.4 μg%; C18:1trans, elaidic acid, 3.5 μg%; C18:2, linoleic acid, 10.1 μg%) produce anxiolytic-like effects that are comparable to diazepam in Wistar rats, suggesting the involvement ofγ-aminobutyric acid-A (GABAA) receptors, a possibility not yet explored. Wistar rats were subjected to the defensive burying test, elevated plus maze, and open field test. In different groups, threeGABAAreceptor antagonists were administered 30 min before FAT-M administration, including the competitive GABA binding antagonist bicuculline (1 mg/kg),GABAAbenzodiazepine antagonist flumazenil (5 mg/kg), and noncompetitiveGABAAchloride channel antagonist picrotoxin (1 mg/kg). The FAT-M exerted anxiolytic-like effects in the defensive burying test and elevated plus maze, without affecting locomotor activity in the open field test. TheGABAAantagonists alone did not produce significant changes in the behavioral tests. Picrotoxin but not bicuculline or flumazenil blocked the anxiolytic-like effect of the FAT-M. Based on the specific blocking action of picrotoxin on the effects of the FAT-M, we conclude that the FAT-M exerted its anxiolytic-like effects throughGABAAreceptor chloride channels.

Neuropharmacological Activity of Various Fractions Obtained from Solanum aethiopicum (Linn.) Fruit in Mice.

2020 ◽  
Vol 1 (5) ◽  
pp. 12-23
Author(s):  
A.R. Abubakar ◽  
◽  
I.H. Sani ◽  
S. Malami ◽  
A.H. Yaro ◽  
...  
Keyword(s):  
Open Field ◽  
Elevated Plus Maze ◽  
Toxicity Testing ◽  
Aqueous Fraction ◽  
Solanum Aethiopicum ◽  
Elevated Plus Maze Test ◽  
Board Test ◽  
Plus Maze ◽  
Hole Board ◽  
Hole Board Test

Background: Solanum aethiopicum (L.), family Solanaceae, is known as garden eggs. The fruit is used in the treatment of insomnia, diabetes and constipation. Objective: The aim of this study was to evaluate anxiolytic-like activity of fractions obtained from crude methanol extract of Solanum aethiopicum fruit. Method: Acute toxicity testing was conducted according to the OECD guidelines 420 via oral and intraperitoneal routes (ip). n-Hexane (HF), chloroform (CHF), ethyl-acetate (EAF), n-butanol (BF) and residual aqueous fraction (RAF) at doses of 25, 50 and 100 mg/kg ip were experimented using the open field, elevated plus maze, staircase, light dark box and hole-board tests. Results: Results: In open field test, there was statistically significant increase in frequency of central square entry by EAF 25mg/kg, 50mg/kg and 100mg/kg and RAF 25mg/kg, 50mg/kg and 100mg/kg all at p<0.05 compared to distilled water (D/W) group. Elevated plus maze test showed statistically significant increases in open arm entry and duration by CHF 25mg/kg, RAF 25mg/kg and 50mg/kg again at p<0.05. Also, in the staircase test, statistically significant decrease in frequency of rearing with no effect on step climbing was observed by RAF 25mg/kg (p< 0.05) compared to D/W. Light and dark box test produced increased light box entry and duration by EAF 25mg/kg, RAF 25mg/kg and 50mg/ kg at p<0.05. Furthermore, the hole -board test showed statistically significant increases in number of head dips by EAF 50mg/kg and 100mg/kg as well as RAF 25mg/kg, 50mg/kg and 100 mg/kg at p<0.05. Conclusion: The fractions obtained from Solanum aethiopicum fruits possesses anxiolytic-like activity.

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