Differential reactivation by HI-6 in vivo of paraoxon-inhibited rat brain acetylcholinesterase molecular forms

1995 ◽  
Vol 26 (4) ◽  
pp. 347-350 ◽  
Author(s):  
J Bajgar
Keyword(s):  
Rat Brain ◽  
Molecular Forms ◽  
Hi 6 ◽  
Acetylcholinesterase Molecular Forms ◽  
Brain Acetylcholinesterase

Oximes-induced reactivation of rat brain acetylcholinesterase inhibited by VX agent

2004 ◽  
Vol 23 (4) ◽  
pp. 167-171 ◽  
Author(s):  
Kamil Kuča ◽  
Jiří Kassa
Keyword(s):  
Rat Brain ◽  
Brain Homogenate ◽  
Hi 6 ◽  
Brain Acetylcholinesterase

A comparison of one mono- and seven bisquaternary acetylcholinesterase (AChE) reactivators of acetylcholinesterase inhibited by VX agent was performed. As a source of the acetylcholinesterase, a rat brain homogenate was taken. There were significant differences in reactivation potency of all tested oximes. The oxime TO205 seems to be the most efficacious followed by TO046, HI-6, HS-6, K027, obidoxime, MMC and 2-PAM. In addition, the results of this study showed that the reactivation potency of the tested reactivators depends on many factors-such as the number of pyridinium rings, the number of oxime groups and their position, as well as the length and the shape of linkage bridge between two pyridinium rings.

Preferential inhibition of acetylcholinesterase molecular forms in rat brain

1992 ◽  
Vol 17 (5) ◽  
pp. 489-495 ◽  
Author(s):  
Nobuo Ogane ◽  
Ezio Giacobini ◽  
Erik Messamore
Keyword(s):  
Rat Brain ◽  
Molecular Forms ◽  
Acetylcholinesterase Molecular Forms

The Reactivating and Therapeutic Efficacy of Oximes to Counteract Russian VX Poisonings

2006 ◽  
Vol 25 (5) ◽  
pp. 397-401 ◽  
Author(s):  
Jiri Kassa ◽  
Daniel Jun ◽  
Kamil Kuca
Keyword(s):  
Therapeutic Efficacy ◽  
Central Compartment ◽  
Toxic Effects ◽  
Peripheral Compartment ◽  
Structural Analogue ◽  
Hi 6 ◽  
Alkyl Groups ◽  
Brain Acetylcholinesterase ◽  
Acute Toxic

Russian VX ( O-isobutyl- S-(2-diethylaminoethyl)methylphosphonothioate) is the structural analogue of VX agent. It differs from VX agent ( O-ethyl- S-(2-diisopropylaminoethyl) methylphosphonothioate) by two alkyl groups. The potency of currently available oximes (pralidoxime, obidoxime, HI-6) to reactivate Russian VX–inhibited acetylcholinesterase and to eliminate Russian VX–induced acute toxic effects was evaluated using in vivo methods. In vivo determined percentage of reactivation of Russian VX–inhibited blood and brain acetylcholinesterase in poisoned rats shows that HI-6 seems to be the most efficacious reactivator of Russian VX–inhibited acetylcholinesterase among currently used oximes in the peripheral compartment, whereas no difference between reactivating efficacy of all tested oximes was observed in the central compartment. The oxime HI-6 was also found to be the most efficacious oxime in the elimination of acute lethal toxic effects in Russian VX–poisoned mice among all studied oximes. Thus, the oxime HI-6 seems to be the most suitable oxime for the antidotal treatment of acute poisonings with Russian VX as in the case of VX, sarin, cyclosarin, and soman poisonings.

KA-672 inhibits rat brain acetylcholinesterase in vitro but not in vivo

1999 ◽  
Vol 263 (2-3) ◽  
pp. 193-196 ◽  
Author(s):  
Michael Hilgert ◽  
Michael Nöldner ◽  
Shyam S Chatterjee ◽  
Jochen Klein
Keyword(s):  
Rat Brain ◽  
Brain Acetylcholinesterase
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