Effect of major histocompatibility complex matching on the development of tolerance to primarily vascularized renal allografts: A study in miniature swine

1996 ◽  
Vol 50 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Pierre R. Gianello ◽  
David H. Sachs
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility ◽  
Miniature Swine ◽  
Renal Allografts ◽  
Histocompatibility Complex ◽  
Development Of Tolerance

scholarly journals The role of subregions of the rat major histocompatibility complex in the rejection and passive enhancement of renal allografts.

1979 ◽  
Vol 149 (1) ◽  
pp. 244-253 ◽  
Author(s):  
G G Gallico ◽  
G W Butcher ◽  
J C Howard
Keyword(s):  
Major Histocompatibility Complex ◽  
Acute Rejection ◽  
Major Histocompatibility ◽  
Norway Rat ◽  
Renal Allografts ◽  
Histocompatibility Complex ◽  
Single Region ◽  
Recombinant Haplotype ◽  
Histocompatibility Locus

The laboratory recombinant haplotype H-1acl of the Norway rat has been used in studies of the rejection and passive enhancement of kidney allografts. While the full H-1a haplotype provoked acute rejection, neither of the isolated subregions, H-1Aa and H-1Ba, did so. It was also found that alloantisera raised against either the H-1Aa or the H-1Ba antigens would enhance the grafts. It is suggested that both MHC subregions contain a histocompatibility locus (i) for kidney (as they do for skin) and that in the genetic combinations studied only incompatibility for both provokes a response sufficient for rejection. In other combinations, however, single region incompatibilities may be sufficient.

Establishment of major histocompatibility complex homozygous gnotobiotic miniature swine colony for xenotransplantation

2014 ◽  
Vol 86 (4) ◽  
pp. 468-475 ◽  
Author(s):  
Jeong Ho Hwang ◽  
Mukesh Kumar Gupta ◽  
Chan Kyu Park ◽  
Yoon Berm Kim ◽  
Hoon Taek Lee
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility ◽  
Miniature Swine ◽  
Histocompatibility Complex
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