scholarly journals Tolerogenicity of Donor Major Histocompatibility Complex–Matched Skin Grafts in Previously Tolerant Massachusetts General Hospital Miniature Swine

2012 ◽  
Vol 94 (12) ◽  
pp. 1192-1199 ◽  
Author(s):  
Joshua Weiner ◽  
Joseph Scalea ◽  
Yoshinori Ishikawa ◽  
Masayoshi Okumi ◽  
Adam Griesemer ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
General Hospital ◽  
Massachusetts General Hospital ◽  
Skin Grafts ◽  
Major Histocompatibility ◽  
Miniature Swine ◽  
Histocompatibility Complex

scholarly journals Mechanism of the rejection of major histocompatibility complex class I-disparate murine skin grafts: rejection can be mediated by CD4+ cells activated by allo-class I + II antigen in CD8+ cell-depleted hosts.

1992 ◽  
Vol 176 (2) ◽  
pp. 617-621 ◽  
Author(s):  
E Kobayashi ◽  
K Kawai ◽  
Y Ikarashi ◽  
M Fujiwara
Keyword(s):  
Major Histocompatibility Complex ◽  
Mhc Class I ◽  
Class I ◽  
Epithelial Tissue ◽  
Skin Grafts ◽  
Major Histocompatibility ◽  
Cd4 Cells ◽  
Cd8 Cells ◽  
Histocompatibility Complex ◽  
Rejection Mechanism

In the preceding article, we analyzed the immunohistochemical rejection mechanism of major histocompatibility complex (MHC) class I (H-2K)-disparate murine skin grafts, and showed that only CD8+ cells infiltrated at the site of the epithelial tissue of MHC class I-disparate graft. We also showed that perfect survival of MHC class I-disparate grafts were attained in thymectomized recipients treated with anti-Lyt-2 monoclonal antibody. In this report, we showed that these long-surviving allo-class I grafts were rejected in the absence of CD8+ cells by stimulation with allo-MHC class I + II-disparate graft as the second stimulation. Furthermore, it was immunohistochemically revealed that under that condition, a large number of CD4+ cells infiltrated into the epithelial tissue of these long-surviving class I grafts, which were going to be rejected 2-5 d after the transplantation of a second graft with MHC class I + II difference. This result directly shows that CD4+ cells are able to became effectors for the rejection of allo-MHC class I (H-2K) skin graft.

CHRONIC REJECTION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II-DISPARATE SKIN GRAFTS AFTER ANTI-CD3 THERAPY

1998 ◽  
Vol 66 (11) ◽  
pp. 1537-1544 ◽  
Author(s):  
Alain Le Moine ◽  
V??ronique Flamand ◽  
Jean Christophe No??l ◽  
Isabelle Fayt ◽  
Michel Goldman ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Chronic Rejection ◽  
Class Ii ◽  
Skin Grafts ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex
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