Hepatocyte Growth Factor Sustains T Regulatory Cells and Prolongs the Survival of Kidney Allografts in Major Histocompatibility Complex-Inbred CLAWN-Miniature Swine

2012 ◽  
Vol 93 (2) ◽  
pp. 148-155 ◽  
Author(s):  
Manei Oku ◽  
Masayoshi Okumi ◽  
Akira Shimizu ◽  
Hisashi Sahara ◽  
Kentaro Setoyama ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
T Regulatory Cells ◽  
Regulatory Cells ◽  
Major Histocompatibility ◽  
Miniature Swine ◽  
Histocompatibility Complex ◽  
Hepatocyte Growth

HEPATOCYTE GROWTH FACTOR PROLONGS ALLOGRAFT SURVIVAL WITH MAINTENANCE OF TREG POPULATION IN MHC-INBRED CLAWN MINIATURE SWINE

2009 ◽  
Vol 181 (4S) ◽  
pp. 741-741
Author(s):  
Hiroaki Nishimura ◽  
Manei Oku ◽  
Masayoshi Okumi ◽  
Hisashi Sahara ◽  
Kentaro Setoyama ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Allograft Survival ◽  
Miniature Swine ◽  
Treg Population ◽  
Hepatocyte Growth

scholarly journals Interaction between major histocompatibility complex antigens and epidermal growth factor receptors on human cells.

1984 ◽  
Vol 98 (2) ◽  
pp. 725-731 ◽  
Author(s):  
A B Schreiber ◽  
J Schlessinger ◽  
M Edidin
Keyword(s):  
Major Histocompatibility Complex ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Human Fibroblasts ◽  
Human Cells ◽  
Membrane Receptors ◽  
Major Histocompatibility ◽  
Mhc Antigens ◽  
Histocompatibility Complex ◽  
Epidermal Growth

It has been suggested that products of the major histocompatibility complex, the MHC, of vertebrates function in many processes of recognition and ligand binding at the cell surface. Here we show that binding of polyclonal and monoclonal antibodies against human MHC antigens, HLA, reduced the binding of epidermal growth factor (EGF) to its membrane receptors on A-431 tumor cells and on normal human fibroblasts. Binding of EGF at 37 degrees C similarly inhibited the binding of Fab fragments and intact Ig anti-HLA to human cells. The inhibitory effect of anti-HLA antibodies was rapid and dependent upon temperature and antibody concentration and valence. Fluorescence microscopy qualitatively confirmed the binding data and showed that MHC antigens and EGF-receptors do not co-cluster in the membrane.

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