The influence of streptozotocin-induced diabetes mellitus on the sensitivity of rat urinary bladder body and base strips to changes in extracellular calcium

1992 ◽  
Vol 23 (1) ◽  
pp. 83-88 ◽  
Author(s):  
Penelope A. Longhurst ◽  
Thomas P. Brotcke ◽  
Robert E. Leggett ◽  
Robert M. Levin
Keyword(s):  
Diabetes Mellitus ◽  
Urinary Bladder ◽  
Extracellular Calcium ◽  
Rat Urinary Bladder ◽  
Streptozotocin Induced Diabetes

The influence of diabetes mellitus on glucose utilization by the rat urinary bladder

Metabolism ◽  
1993 ◽  
Vol 42 (6) ◽  
pp. 749-755 ◽  
Author(s):  
Penelope A. Longhurst ◽  
Janice A.K. Briscoe ◽  
Robert E. Leggett ◽  
Saeed Samadzadeh ◽  
Robert M. Levin
Keyword(s):  
Diabetes Mellitus ◽  
Urinary Bladder ◽  
Glucose Utilization ◽  
Rat Urinary Bladder

Impairment and restoration of rat urinary bladder responsiveness following distension

1983 ◽  
Vol 244 (1) ◽  
pp. R106-R113 ◽  
Author(s):  
F. G. Carpenter
Keyword(s):  
Diabetes Mellitus ◽  
Urinary Bladder ◽  
Transmitter Release ◽  
Bladder Dysfunction ◽  
Contractile Element ◽  
Tetraethylammonium Chloride ◽  
Rat Urinary Bladder ◽  
Tension Development ◽  
Resting Pressure

Micturition and bladder responsiveness in vitro were impaired in rats fed isotonic sucrose, afflicted with diabetes mellitus or diabetes insipidus. Their urinary output which was seven times control, initiated micturition responses at volumes three times control. Nerve-induced contractions by bladders from these rats developed substantially less pressure than control. Contractions elicited at 1 Hz by control and impaired bladders were potentiated equally by tetraethylammonium chloride (TEA) (5 mM) or by carbachol (2 X 10(-7) M). Contractions elicited at 20 Hz by normal bladders were not potentiated, those by impaired bladders were. TEA, by increasing transmitter release, and carbachol, by a postjunctional action, substantially reversed bladder dysfunction. Because control and impaired bladders were equally enhanced by TEA, prejunctional and contractile element (CE) activity at 1 Hz were probably unaffected by distension. However, postjunctional sensitivity was probably reduced. Impaired bladders, more compliant than controls, became less compliant after carbachol without elevating resting pressure. Whereas the action of carbachol to enhance bladder responsiveness did not involve tension development, there may have been cholinoceptor facilitation and shortening of CE.

3H-Thymidine Uptake by the Rat Urinary Bladder After Induction Of Diabetes Mellitus

1993 ◽  
Vol 150 (4) ◽  
pp. 1316-1320 ◽  
Author(s):  
Berit Eika ◽  
Robert M. Levin ◽  
Frederick C. Monson ◽  
Miles Murphy ◽  
Penelope A. Longhurst
Keyword(s):  
Diabetes Mellitus ◽  
Urinary Bladder ◽  
Thymidine Uptake ◽  
Rat Urinary Bladder
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