scholarly journals Responses of the melanophores of the medaka, Oryzias latipes, to adrenergic drugs: Evidence for involvement of alpha2 adrenergic receptors mediating melanin aggregation

1987 ◽  
Vol 88 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Morishita Fumihiro
Keyword(s):  
Adrenergic Receptors ◽  
Oryzias Latipes ◽  
Adrenergic Drugs

scholarly journals THE CHANGES OF HUMORAL ADRENERGIC REGULATION OF HEART IN ALCOHOL-TREATED RATS

2017 ◽  
Vol 13 (1-2) ◽  
pp. 3-11
Author(s):  
T.I. Panova ◽  
M.I. Koshelnyk ◽  
S.N. Scherbak
Keyword(s):  
Heart Rate ◽  
Adrenergic Receptors ◽  
Sympathoadrenal System ◽  
Basal Secretion ◽  
Adrenergic Regulation ◽  
Adrenergic Drugs ◽  
Genes Expression ◽  
Systemic Manifestations ◽  
Selective Blocker

Relevance. Under the chronic influence of ethanol the genes expression is changed which contain the information about synthesis of adrenergic receptors, epinephrine enzymes. However studies of the systemic manifestations of these changes are unknown. The distortion of the adrenergic drugs effect in an alcohol-treated organism is probable. Objective: to investigate the adrenergic regulation of the heart in alcohol-treated rates by means of variation of the number of β1 receptors and their ligands. Materials and methods. In control (n=10) and alcohol-treated rats chronically for 120 days (n=10) the number of β1-adrenergic receptors (by means of administration of concor cor selective blocker – 0,28 mg/kg) and the quantity of epinephrine in the blood (by means of activation of sympathoadrenal system after sodium caffeine-benzoate injection – 7,14 mg/kg) were varied. The concor cor and caffeine were administered separately and together. The heart rate (HR) was recorded with the help of sphygmomanometer. The results were processed by using MedStat package. Results. In alcohol-treated rats chronically the HR is 27,6±2,5% higher than in the control ones (383,8±12,9 min-1 and 300,8±8,7 min-1). The caffeine administration leads to an increase in heart rate by 11,5±1,1 % in control rats (up to 335,4±9,5 min-1) while it doesn’t affect this index in alcohol-treated rats (389,6±12,6 min-1). The blockade of β1 receptors leads to a decrease in the HR by 7,5±0,7 % (up to 278,2±7,9 min-1) in control rats and by 15,5±1,1 % (up to 324,4±9,3 min-1) in alcohol-treated rats. When co-administration the β1 receptors blocker and caffeine have nivelated the opposite effects of each other in the control rats and HR remained the same (307,0±8,2 min-1); this has resulted in a decrease in the HR by 4,8±1,0 % (up to 365,4±10,9 min-1) in alcohol-treated animals. Conclusions. It is assumed that the basal secretion of epinephrine is increased and the number of β1 receptors is decreased in alcohol-treated rats compared to control ones.

Use of the Japanese Medaka ( Oryzias latipes ) and Guppy ( Poecilia reticulata ) in Carcinogenesis Testing Under National Toxicology Program Protocols

2003 ◽  
Vol 31 (1) ◽  
pp. 88-91 ◽  
Author(s):  
William E. Hawkins ◽  
William W. Walker ◽  
John W. Fournie ◽  
C. Steve Manning ◽  
Rena M. Krol
Keyword(s):  
Poecilia Reticulata ◽  
Oryzias Latipes ◽  
Japanese Medaka ◽  
National Toxicology Program

History of vascular reactivity models and their involvement in hypertension pathogenesis

VASA ◽  
2017 ◽  
Vol 46 (6) ◽  
pp. 431-439 ◽  
Author(s):  
Ana Gabriela Conceição-Vertamatti ◽  
Filipy Borghi ◽  
Fernando Canova ◽  
Dora Maria Grassi-Kassisse
Keyword(s):  
Blood Pressure ◽  
Adrenergic Receptors ◽  
Vascular Reactivity ◽  
Multifactorial Disease ◽  
Pharmacological Treatments ◽  
Beta Adrenergic Receptors ◽  
Vascular Area ◽  
History Of ◽  
Record Blood Pressure ◽  
Advance Knowledge

Abstract. Hypertension is a silent and multifactorial disease. Over two centuries ago, the first device to record blood pressure was developed, making it possible to determine normotension and to establish criteria for hypertension. Since then, several studies have contributed to advance knowledge in this area, promoting significant advances in pharmacological treatments and, as a result, increasing survival of hypertensive people. The main models developed for the study of hypertension and the main findings in the vascular area are included in this review. We considered aspects related to vascular reactivity, changes in the population, and action of beta adrenergic receptors in the pathogenesis of hypertension.

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