Preparation and biological evaluation of 18F-labeled benzamide analogs as potential dopamine D2 receptor ligands

1990 ◽  
Vol 17 (4) ◽  
pp. 347-356 ◽  
Author(s):  
Dale O. Kiesewetter ◽  
Ryosei Kawai ◽  
Meena Chelliah ◽  
Ernest Owens ◽  
Catherine McLellan ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Biological Evaluation ◽  
Receptor Ligands ◽  
Dopamine D2

Design and Radiofluorination of Benzamide Dopamine D2 Receptor Ligands

1991 ◽  
pp. 97-107 ◽  
Author(s):  
Tomas de Paulis ◽  
Danny R. Bingham ◽  
Ronald G. Manning ◽  
N. Scott Mason ◽  
M. Sib Ansari ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Ligands ◽  
Dopamine D2

Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands

2003 ◽  
Vol 11 (22) ◽  
pp. 4807-4813 ◽  
Author(s):  
Ricardo Menegatti ◽  
Anna C Cunha ◽  
Vı́tor F Ferreira ◽  
Edna F.R Perreira ◽  
Ahmed El-Nabawi ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Ligands ◽  
Pharmacological Profile ◽  
Design Synthesis ◽  
Dopamine D2

Pharmacokinetics of the three radioiodinated dopamine D2 receptor ligands [123I]IBF, [123I]epidepride and [123I]2′-ISP in nonhuman primates

1994 ◽  
Vol 21 (7) ◽  
pp. 969-976 ◽  
Author(s):  
Ronald M. Baldwin ◽  
Yolanda Zea-Ponce ◽  
Sami S. Zoghbi ◽  
Mohammed S. Al-Tikriti ◽  
John P. Seibyl ◽  
...  
Keyword(s):  
Nonhuman Primates ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Ligands ◽  
Dopamine D2

An attempt at the hydrated imidazoline ring expansion (HIRE) of diarene-fused [1,4]diazepinones delivers selective dopamine D2 receptor ligands

Synthesis ◽  
2021 ◽  
Author(s):  
Sergey Grintsevich ◽  
Alexander V. Sapegin ◽  
Andrzej Bojarski ◽  
Beata Duszyńska ◽  
Mikhail Krasavin
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Ring Expansion ◽  
Side Chain ◽  
Receptor Ligands ◽  
Structure Activity Relationships ◽  
Dopamine D2 ◽  
Structure Activity ◽  
Imidazoline Ring ◽  
Selective Dopamine

Attempts to extend the hydrated imidazoline ring expansion (HIRE) strategy to a series of diarene-fused [1,4]diazepinones (earlier applied successfully to bis-pyrido substrate nevirapine) resulted in no ring expansion but rather 2-aminoethyl side chain expulsion. This seeming setback (setting the limitations to the HIRE methodology substrate scope) led to the discovery of selective dopamine D2 ligands with elements of structure-activity relationships.

Novel Aza-analogous Ergoline Derived Scaffolds as Potent Serotonin 5-HT6 and Dopamine D2 Receptor Ligands.

2014 ◽  
Vol 57 (13) ◽  
pp. 5823-5828 ◽  
Author(s):  
Niels Krogsgaard-Larsen ◽  
Anders A. Jensen ◽  
Tenna J. Schrøder ◽  
Claus. T. Christoffersen ◽  
Jan Kehler
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Ligands ◽  
Dopamine D2

Preparation and preliminary biological evaluation of [18F]NCQ-115: a new selective reversible dopamine D2 receptor ligand

1993 ◽  
Vol 20 (4) ◽  
pp. 549-555 ◽  
Author(s):  
A. Najafi ◽  
A. Peterson ◽  
M. Buchsbaum ◽  
S. O'Dell ◽  
F. Weihmuller
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Biological Evaluation ◽  
Receptor Ligand ◽  
Dopamine D2

Homobivalent Dopamine D2 Receptor Ligands Modulate the Dynamic Equilibrium of D2 Monomers and Homo- and Heterodimers

2021 ◽  
Vol 16 (2) ◽  
pp. 371-379
Author(s):  
Tamara Ullmann ◽  
Marie Gienger ◽  
Julian Budzinski ◽  
Jan Hellmann ◽  
Harald Hübner ◽  
...  
Keyword(s):  
Dynamic Equilibrium ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Ligands ◽  
Dopamine D2

scholarly journals Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines

2016 ◽  
Vol 81 (4) ◽  
pp. 347-356 ◽  
Author(s):  
Jelena Penjisevic ◽  
Vladimir Sukalovic ◽  
Deana Andric ◽  
Goran Roglic ◽  
Irena Novakovic ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Biological Evaluation ◽  
Activity Relationship ◽  
Docking Analysis ◽  
Dopamine D2

A series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-(piperidin-4-ylmethyl)piperazine. Biological evaluation of the synthesized compounds was pointed out for seven compounds, of which 1-(2-methoxyphenyl)-4-{[1-(2-nitrobenzyl)piperidin-4-yl]methyl}piperazine had the highest affinity for the dopamine D2 receptor. For all seven selected compounds docking analysis was performed in order to establish their structure-to-activity relationship.

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