Preparation and preliminary biological evaluation of [18F]NCQ-115: a new selective reversible dopamine D2 receptor ligand

1993 ◽  
Vol 20 (4) ◽  
pp. 549-555 ◽  
Author(s):  
A. Najafi ◽  
A. Peterson ◽  
M. Buchsbaum ◽  
S. O'Dell ◽  
F. Weihmuller
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Biological Evaluation ◽  
Receptor Ligand ◽  
Dopamine D2

Cerebral kinetics of the dopamine D2 receptor ligand [123I]IBZM in mice

2008 ◽  
Vol 35 (4) ◽  
pp. 467-473 ◽  
Author(s):  
Philipp T. Meyer ◽  
Dagmar Salber ◽  
Johannes Schiefer ◽  
Markus Cremer ◽  
Wolfgang M. Schaefer ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Ligand ◽  
Dopamine D2 ◽  
Kinetics Of

SSR181507, a dopamine D2 receptor and 5-HT1A receptor ligand: Evidence for mixed anxiolytic- and antidepressant-like activities

2011 ◽  
Vol 97 (3) ◽  
pp. 428-435 ◽  
Author(s):  
Denis Boulay ◽  
Ronan Depoortere ◽  
Caroline Louis ◽  
Martine Lacave ◽  
Marie Thérèse Lucas ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Ligand ◽  
Dopamine D2

The dopamine D2 receptor ligand 18F-desmethoxyfallypride: an appropriate fluorinated PET tracer for the differential diagnosis of parkinsonism

2004 ◽  
Vol 31 (8) ◽  
Author(s):  
Mathias Schreckenberger ◽  
Stefan H�gele ◽  
Thomas Siessmeier ◽  
Hans-Georg Buchholz ◽  
Heike Armbrust-Henrich ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Ligand ◽  
Dopamine D2 ◽  
Pet Tracer

Effects of acute and repeated treatment with a novel dopamine D2 receptor ligand on l-DOPA-induced dyskinesias in MPTP monkeys

2001 ◽  
Vol 412 (3) ◽  
pp. 247-254 ◽  
Author(s):  
Abdallah Hadj Tahar ◽  
Anna Ekesbo ◽  
Laurent Grégoire ◽  
Evelyne Bangassoro ◽  
Kjell A Svensson ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Repeated Treatment ◽  
Receptor Ligand ◽  
Dopamine D2

scholarly journals Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines

2016 ◽  
Vol 81 (4) ◽  
pp. 347-356 ◽  
Author(s):  
Jelena Penjisevic ◽  
Vladimir Sukalovic ◽  
Deana Andric ◽  
Goran Roglic ◽  
Irena Novakovic ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Biological Evaluation ◽  
Activity Relationship ◽  
Docking Analysis ◽  
Dopamine D2

A series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-(piperidin-4-ylmethyl)piperazine. Biological evaluation of the synthesized compounds was pointed out for seven compounds, of which 1-(2-methoxyphenyl)-4-{[1-(2-nitrobenzyl)piperidin-4-yl]methyl}piperazine had the highest affinity for the dopamine D2 receptor. For all seven selected compounds docking analysis was performed in order to establish their structure-to-activity relationship.

Sign in / Sign up

Export Citation Format

Share Document