Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines
2016 ◽
Vol 81
(4)
◽
pp. 347-356
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Keyword(s):
A series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-(piperidin-4-ylmethyl)piperazine. Biological evaluation of the synthesized compounds was pointed out for seven compounds, of which 1-(2-methoxyphenyl)-4-{[1-(2-nitrobenzyl)piperidin-4-yl]methyl}piperazine had the highest affinity for the dopamine D2 receptor. For all seven selected compounds docking analysis was performed in order to establish their structure-to-activity relationship.
1990 ◽
Vol 17
(4)
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pp. 347-356
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Keyword(s):
1993 ◽
Vol 20
(4)
◽
pp. 549-555
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Keyword(s):
2019 ◽
Vol 20
(18)
◽
pp. 4555
◽
2005 ◽
Vol 40
(5)
◽
pp. 481-493
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Keyword(s):
2005 ◽
Vol 25
(1_suppl)
◽
pp. S646-S646