ACTION BY THE LUNGS ON CIRCULATING XENOBIOTIC AGENTS, WITH A CASE STUDY OF PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING OF BENZO(a)PYRENE DISPOSITION

Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells ◽

10.1016/b978-0-08-041177-4.50010-9 ◽

1993 ◽

pp. 89-105

Author(s):

ROBERT A. ROTH ◽

ALLEN VINEGAR

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

An Investigation of Oral Exposure Variability and Formulation Strategy: A Case Study of PI3Kδ Inhibitor and Physiologically Based Pharmacokinetic Modeling in Beagle Dogs

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2017.06.014 ◽

2018 ◽

Vol 107 (1) ◽

pp. 466-475 ◽

Author(s):

Po-Chang Chiang ◽

Jodie Pang ◽

Jia Liu ◽

Laurent Salphati

Keyword(s):

Pharmacokinetic Modeling ◽

Oral Exposure ◽

Physiologically Based Pharmacokinetic Modeling ◽

Beagle Dogs ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Physiologically based pharmacokinetic modeling to predict complex drug-drug interactions: a case study of AZD2327 and its metabolite, competitive and time-dependent CYP3A inhibitors

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.1962 ◽

2015 ◽

Vol 36 (8) ◽

pp. 507-519 ◽

Author(s):

Jian Guo ◽

Diansong Zhou ◽

Yan Li ◽

Bui H. Khanh

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Time Dependent ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Download Full-text

Predicting Drug-Drug Interactions Involving Multiple Mechanisms Using Physiologically Based Pharmacokinetic Modeling: A Case Study With Ruxolitinib

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.30 ◽

2014 ◽

Vol 97 (2) ◽

pp. 177-185 ◽

Author(s):

JG Shi ◽

G Fraczkiewicz ◽

WV Williams ◽

S Yeleswaram

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Incorporation of Physiologically Based Pharmacokinetic Modeling in the Evaluation of Solubility Requirements for the Salt Selection Process: A Case Study Using Phenytoin

The AAPS Journal ◽

10.1208/s12248-013-9519-x ◽

2013 ◽

Vol 15 (4) ◽

pp. 1109-1118 ◽

Author(s):

Po-Chang Chiang ◽

Harvey Wong

Keyword(s):

Selection Process ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Download Full-text

Action by the lungs on circulating xenobiotic agents, with a case study of physiologically based pharmacokinetic modeling of benzo(a)pyrene disposition

Pharmacology & Therapeutics ◽

10.1016/0163-7258(90)90078-g ◽

1990 ◽

Vol 48 (2) ◽

pp. 143-155 ◽

Author(s):

Robert A. Roth ◽

Allen Vinegar

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite: A Case Study of Amiodarone

Drug Metabolism and Disposition ◽

10.1124/dmd.114.059311 ◽

2014 ◽

Vol 43 (2) ◽

pp. 182-189 ◽

Author(s):

Yuan Chen ◽

Jialin Mao ◽

Cornelis E. C. A. Hop

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Using Compartmentalized Inhalation Physiologically-Based Pharmacokinetic Modeling to Calculate Occupational and Environmental Risks: A Case Study Involving Toluene

Applied Occupational and Environmental Hygiene ◽

10.1080/104732200301214 ◽

2000 ◽

Vol 15 (6) ◽

pp. 457-462

Author(s):

N. J. Giardino ◽

C. R. Wilkes ◽

P. F. Ricci ◽

J. R. Wireman

Keyword(s):

Pharmacokinetic Modeling ◽

Environmental Risks ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Physiologically based pharmacokinetic modeling to predict exposures in healthy Japanese subjects with different CYP2C19 phenotypes: Esomeprazole case study

International Journal of Clinical Pharmacology and Therapeutics ◽

10.5414/cp203488 ◽

2020 ◽

Vol 58 (01) ◽

pp. 29-36 ◽

Author(s):

Mitsuo Higashimori ◽

Hitoshi Shimada ◽

Katsuomi Ichikawa ◽

Diansong Zhou

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Japanese Subjects

Download Full-text

Assessing Human Variability in Kinetics for Exposures to Multiple Environmental Chemicals: A Physiologically Based Pharmacokinetic Modeling Case Study with Dichloromethane, Benzene, Toluene, Ethylbenzene, andm-Xylene

Journal of Toxicology and Environmental Health Part A ◽

10.1080/15287394.2014.971477 ◽

2015 ◽

Vol 78 (7) ◽

pp. 409-431 ◽

Author(s):

Mathieu Valcke ◽

Sami Haddad

Keyword(s):

Pharmacokinetic Modeling ◽

Environmental Chemicals ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Benzene Toluene

Download Full-text

Physiologically-based pharmacokinetic modeling of different size polyethylene glycol-coated gold nanoparticles in mice

10.1615/ihtc16.nmt.023362 ◽

2018 ◽

Author(s):

Linjing Deng ◽

Jinping Zhao ◽

Yufeng Miao ◽

Xu Hu ◽

Qihong Deng

Keyword(s):

Gold Nanoparticles ◽

Polyethylene Glycol ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text