Physiologically based pharmacokinetic modeling to predict complex drug-drug interactions: a case study of AZD2327 and its metabolite, competitive and time-dependent CYP3A inhibitors

Time Dependent ◽

Physiologically Based ◽

Complex Drug

Predicting Drug-Drug Interactions Involving Multiple Mechanisms Using Physiologically Based Pharmacokinetic Modeling: A Case Study With Ruxolitinib

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.30 ◽

2014 ◽

Vol 97 (2) ◽

pp. 177-185 ◽

Cited By ~ 14

Author(s):

JG Shi ◽

G Fraczkiewicz ◽

WV Williams ◽

S Yeleswaram

Keyword(s):

Drug Interactions ◽

Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic Modeling

Drug Metabolism and Disposition ◽

10.1124/dmd.117.079210 ◽

2018 ◽

Vol 46 (7) ◽

pp. 924-933 ◽

Cited By ~ 5

Author(s):

Yoshiaki Yao ◽

Kota Toshimoto ◽

Soo-Jin Kim ◽

Takashi Yoshikado ◽

Yuichi Sugiyama

Keyword(s):

Quantitative Analysis ◽

Drug Interactions ◽

Physiologically Based ◽

Transport Inhibitors ◽

Complex Drug

Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite: A Case Study of Amiodarone

Drug Metabolism and Disposition ◽

10.1124/dmd.114.059311 ◽

2014 ◽

Vol 43 (2) ◽

pp. 182-189 ◽

Cited By ~ 34

Author(s):

Yuan Chen ◽

Jialin Mao ◽

Cornelis E. C. A. Hop

Keyword(s):

Drug Interactions ◽

Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug‐Drug Interactions With Ethionamide Involving Impact of Genetic Polymorphism on FMO3

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1378 ◽

2019 ◽

Vol 59 (6) ◽

pp. 880-889 ◽

Cited By ~ 1

Author(s):

Phuong Thi Thu Nguyen ◽

Md Masud Parvez ◽

Min Jung Kim ◽

Sung Eun Yoo ◽

Sangzin Ahn ◽

...

Keyword(s):

Genetic Polymorphism ◽

Drug Interactions ◽

Modeling Approach ◽

An Investigation of Oral Exposure Variability and Formulation Strategy: A Case Study of PI3Kδ Inhibitor and Physiologically Based Pharmacokinetic Modeling in Beagle Dogs

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2017.06.014 ◽

2018 ◽

Vol 107 (1) ◽

pp. 466-475 ◽

Cited By ~ 3

Author(s):

Po-Chang Chiang ◽

Jodie Pang ◽

Jia Liu ◽

Laurent Salphati

Keyword(s):

Oral Exposure ◽

Beagle Dogs ◽

ACTION BY THE LUNGS ON CIRCULATING XENOBIOTIC AGENTS, WITH A CASE STUDY OF PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING OF BENZO(a)PYRENE DISPOSITION

Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells ◽

10.1016/b978-0-08-041177-4.50010-9 ◽

1993 ◽

pp. 89-105

Author(s):

ROBERT A. ROTH ◽

ALLEN VINEGAR

Keyword(s):

Pain Chemogenomics Knowledgebase (Pain-CKB) for Systems Pharmacology Target Mapping and Physiologically Based Pharmacokinetic Modeling Investigation of Opioid Drug–Drug Interactions

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.0c00372 ◽

2020 ◽

Vol 11 (20) ◽

pp. 3245-3258

Author(s):

Mingzhe Shen ◽

Maozi Chen ◽

Tianjian Liang ◽

Siyi Wang ◽

Ying Xue ◽

...

Keyword(s):

Drug Interactions ◽

Systems Pharmacology ◽

Implementation of a Physiologically Based Pharmacokinetic Modeling Approach to Guide Optimal Dosing Regimens for Imatinib and Potential Drug Interactions in Paediatrics

Frontiers in Pharmacology ◽

10.3389/fphar.2019.01672 ◽

2020 ◽

Vol 10 ◽

Cited By ~ 2

Author(s):

Jeffry Adiwidjaja ◽

Alan V. Boddy ◽

Andrew J. McLachlan

Keyword(s):

Drug Interactions ◽

Potential Drug ◽

Modeling Approach ◽

Optimal Dosing ◽

Physiologically Based ◽

Dosing Regimens

Physiologically‐Based Pharmacokinetic Modeling for Predicting Drug Interactions of a Combination of Olanzapine and Samidorphan

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12488 ◽

2020 ◽

Vol 9 (2) ◽

pp. 106-114 ◽

Cited By ~ 2

Author(s):

Lei Sun ◽

Lisa Moltke ◽

Karen Rowland Yeo

Keyword(s):

Drug Interactions ◽

Physiologically based pharmacokinetic modeling of disposition and drug–drug interactions for atorvastatin and its metabolites

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2015.06.019 ◽

2015 ◽

Vol 77 ◽

pp. 216-229 ◽

Cited By ~ 18

Author(s):

Tao Zhang

Keyword(s):

Drug Interactions ◽