KINETIC ISOTOPE EFFECTS IN CYTOCHROME P-450-CATALYZED OXIDATION REACTIONS. I. SUBSTRATE - CYTOCHROME P-450 INTERACTIONS

Microsomes, Drug Oxidations and Chemical Carcinogenesis ◽

10.1016/b978-0-12-187701-9.50071-1 ◽

1980 ◽

pp. 363-366 ◽

Author(s):

Gerald T. Miwa ◽

Jonathan S. Zweig ◽

John S.A. Walsh ◽

Anthony Y.H. Lu

Keyword(s):

Isotope Effects ◽

Kinetic Isotope Effects ◽

Oxidation Reactions ◽

Kinetic Isotope ◽

Cytochrome P 450 ◽

Catalyzed Oxidation

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Kinetic Isotope Effects in Cytochrome P-450-Catalyzed Oxidation Reactions. II. Interactions of Cytochrome P-450 with Substrates and Nadph-Cytochrome % MathType!MTEF!2!1!+-% feaagCart1ev2aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXatLxBI9gBaerbd9wDYLwzYbItLDharqqtubsr% 4rNCHbGeaGqiVu0Je9sqqrpepC0xbbL8F4rqqrFfpeea0xe9Lq-Jc9% vqaqpepm0xbba9pwe9Q8fs0-yqaqpepae9pg0FirpepeKkFr0xfr-x% fr-xb9adbaqaaeGaciGaaiaabeqaamaabaabaaGcbaGabm4yayaaDa% aaaa!3700! $$\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle-}$}}{c} $$ Reductase

Alcohol and Aldehyde Metabolizing Systems-IV ◽

10.1007/978-1-4757-1419-7_11 ◽

1980 ◽

pp. 95-108 ◽

Author(s):

Anthony Y. H. Lu ◽

Gerald T. Miwa ◽

Susan B. West ◽

Barbara J. Hodshon ◽

William A. Garland

Keyword(s):

Isotope Effects ◽

Kinetic Isotope Effects ◽

Oxidation Reactions ◽

Nadph Cytochrome ◽

Kinetic Isotope ◽

Cytochrome P 450 ◽

Catalyzed Oxidation

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Kinetic isotope effects in cytochrome P-450-catalyzed oxidation reactions. Intermolecular and intramolecular deuterium isotope effects during the N-demethylation of N,N-dimethylphentermine.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)43699-x ◽

1980 ◽

Vol 255 (13) ◽

pp. 6049-6054 ◽

Author(s):

G.T. Miwa ◽

W.A. Garland ◽

B.J. Hodshon ◽

A.Y. Lu ◽

D.B. Northrop

Keyword(s):

Isotope Effects ◽

Kinetic Isotope Effects ◽

Oxidation Reactions ◽

Kinetic Isotope ◽

Deuterium Isotope Effects ◽

Cytochrome P 450 ◽

Catalyzed Oxidation

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Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. Evidence for the irreversible formation of an activated oxygen intermediate of cytochrome P-448.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)43249-2 ◽

1984 ◽

Vol 259 (5) ◽

pp. 3005-3010 ◽

Author(s):

N Harada ◽

G T Miwa ◽

J S Walsh ◽

A Y Lu

Keyword(s):

Isotope Effects ◽

Kinetic Isotope Effects ◽

Oxidation Reactions ◽

Kinetic Isotope ◽

Activated Oxygen ◽

Cytochrome P 450 ◽

Catalyzed Oxidation

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Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. The oxidative O-dealkylation of 7-ethoxycoumarin.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)43248-0 ◽

1984 ◽

Vol 259 (5) ◽

pp. 3000-3004

Author(s):

G T Miwa ◽

J S Walsh ◽

A Y Lu

Keyword(s):

Isotope Effects ◽

Kinetic Isotope Effects ◽

Oxidation Reactions ◽

Kinetic Isotope ◽

Cytochrome P 450 ◽

Catalyzed Oxidation

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Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions: Full expression of the intrinsic isotope effect during the O-deethylation of 7-ethoxycoumarin by liver microsomes from 3-methylcholanthrene-induced hamsters

Archives of Biochemistry and Biophysics ◽

10.1016/0003-9861(85)90822-7 ◽

1985 ◽

Vol 239 (1) ◽

pp. 155-162 ◽

Author(s):

Gerald T. Miwa ◽

Nobuhiro Harada ◽

Anthony Y.H. Lu

Keyword(s):

Isotope Effect ◽

Isotope Effects ◽

Liver Microsomes ◽

Kinetic Isotope Effects ◽

Oxidation Reactions ◽

Kinetic Isotope ◽

Full Expression ◽

Cytochrome P 450 ◽

Catalyzed Oxidation

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Nitrogen Kinetic Isotope Effects for the Monoamine Oxidase B-Catalyzed Oxidation of Benzylamine and (1,1-2H2)Benzylamine: Nitrogen Rehybridization and CH Bond Cleavage Are Not Concerted

Journal of the American Chemical Society ◽

10.1021/ja205629b ◽

2011 ◽

Vol 133 (32) ◽

pp. 12319-12321 ◽

Author(s):

Susanna MacMillar ◽

Dale E. Edmondson ◽

Olle Matsson

Keyword(s):

Monoamine Oxidase ◽

Bond Cleavage ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Monoamine Oxidase B ◽

Kinetic Isotope ◽

Catalyzed Oxidation

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Tunneling in C−H Oxidation Reactions by an Oxoiron(IV) Porphyrin Radical Cation: Direct Measurements of Very Large H/D Kinetic Isotope Effects

Journal of the American Chemical Society ◽

10.1021/ja802484n ◽

2008 ◽

Vol 130 (25) ◽

pp. 7776-7777 ◽

Author(s):

Zhengzheng Pan ◽

John H. Horner ◽

Martin Newcomb

Keyword(s):

Radical Cation ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Oxidation Reactions ◽

Kinetic Isotope ◽

Direct Measurements

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Cytochrome P 450-dependent ethanol oxidation. Kinetic isotope effects and absence of stereoselectivity

Biochemistry ◽

10.1021/bi00397a023 ◽

1987 ◽

Vol 26 (23) ◽

pp. 7348-7354 ◽

Author(s):

Gunilla Ekstroem ◽

Carina Norsten ◽

Tomas Cronholm ◽

Magnus Ingelman-Sundberg

Keyword(s):

Ethanol Oxidation ◽

Isotope Effects ◽

Oxidation Kinetic ◽

Kinetic Isotope Effects ◽

Kinetic Isotope ◽

Cytochrome P 450

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Separation of the primary and secondary kinetic isotope effects at a reactive center using starting material reactivities. Application to the FeCl3-Catalyzed oxidation of CH bonds with tert-butyl hydroperoxide

Tetrahedron Letters ◽

10.1016/s0040-4039(99)00637-1 ◽

1999 ◽

Vol 40 (20) ◽

pp. 3847-3850 ◽

Author(s):

Steven R. Merrigan ◽

Valerie N. Le Gloahec ◽

Jason A. Smith ◽

Derek H.R. Barton ◽

Daniel A. Singleton

Keyword(s):

Isotope Effects ◽

Kinetic Isotope Effects ◽

Starting Material ◽

Butyl Hydroperoxide ◽

Kinetic Isotope ◽

Reactive Center ◽

Tert Butyl Hydroperoxide ◽

Catalyzed Oxidation

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MNDO calculation of kinetic isotope effects in model cytochrome P-450 oxidations

Journal of the American Chemical Society ◽

10.1021/ja00354a044 ◽

1983 ◽

Vol 105 (16) ◽

pp. 5451-5454 ◽

Author(s):

J. Paul Shea ◽

Sidney D. Nelson ◽

George P. Ford

Keyword(s):

Isotope Effects ◽

Kinetic Isotope Effects ◽

Mndo Calculation ◽

Kinetic Isotope ◽

Cytochrome P 450

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