The Role of the Mixed-Function Oxidase System in the Toxication and Detoxication of Chemicals: Relationship to Chemical Interactions

1990 ◽  
pp. 31-60 ◽  
Author(s):  
Gregory L. Kedderis
Keyword(s):  
Mixed Function Oxidase ◽  
Chemical Interactions ◽  
Oxidase System ◽  
Mixed Function Oxidase System

The Detection of Reactive Metabolites Generated by the Microsomal Mixed Function Oxidase System

1988 ◽  
Vol 16 (1) ◽  
pp. 8-13
Author(s):  
Jeffrey R. Fry ◽  
Michael J. Garle ◽  
Alison H. Hammond
Keyword(s):  
Reactive Metabolites ◽  
In Vitro Tests ◽  
Future Trends ◽  
Mixed Function Oxidase ◽  
Oxidase System ◽  
Mixed Function Oxidase System ◽  
Microsomal Mixed Function Oxidase ◽  
Current Emphasis

It is recognised that the cytotoxicity of a number of xenobiotics is mediated through the production of reactive metabolites (1). Given this, and the current emphasis on the development of in vitro tests for assessment of xenobiotic cytotoxicity (2), it is of considerable interest to develop systems for the detection in vitro of cytotoxic reactive metabolites. Indeed, it would seem appropriate to employ a limited battery of tests for detection of xenobiotic-mediated cytotoxicity, some of which would be dedicated to assessment of the role of metabolism in such toxicity. The aim of this review is to identify and discuss the approaches currently being employed to this end, and to suggest some possible future trends.

133. Mechanism of hepatic mixed function oxidase system induction in rats

1978 ◽  
Vol 9 (9) ◽  
pp. 841
Author(s):  
S.S. Pawar ◽  
M.S. Kachole ◽  
S.J. Makhija ◽  
G.K. Hebber ◽  
U.K. Halde ◽  
...  
Keyword(s):  
Mixed Function Oxidase ◽  
Oxidase System ◽  
Mixed Function Oxidase System
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