Glutathione Depletion by Phorone Organ Specificity and Effect on Hepatic Microsomal Mixed-Function Oxidase System

1986 ◽  
Vol 9 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Maged Younes ◽  
Satish C. Sharma ◽  
C. P. Siegers
Keyword(s):  
Glutathione Depletion ◽  
Organ Specificity ◽  
Mixed Function Oxidase ◽  
Oxidase System ◽  
Mixed Function Oxidase System ◽  
Microsomal Mixed Function Oxidase

Phenobarbitone-induced urinary excretions of D-glucaric acid and 6β-hydroxycortisol in man

1976 ◽  
Vol 54 (5) ◽  
pp. 778-782 ◽  
Author(s):  
A. N. Latham ◽  
P. Turner ◽  
C. Franklin ◽  
W. Maclay
Keyword(s):  
Normal Subjects ◽  
Mixed Function Oxidase ◽  
Glucaric Acid ◽  
Oxidase System ◽  
Mixed Function Oxidase System ◽  
Baseline Values ◽  
Microsomal Mixed Function Oxidase

The urinary excretions of D-glucaric acid and 6β-hydroxycortisol were determined in normal subjects before, during, and after 14 days treatment with placebo or phenobarbitone. The excretion of both metabolites was significantly potentiated by phenobarbitone and returned to baseline values 1 month after treatment was withdrawn. It was suggested that the determination of urinary D-glucaric acid reflects the activity of the hepatic microsomal mixed function oxidase system after the administration of an inducing agent such as phenobarbitone.

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