Cytochrome bc1 Complex (Respiratory Chain Complex III)

2013 ◽  
pp. 593-598
Author(s):  
B.L. Trumpower
Keyword(s):  
Respiratory Chain ◽  
Chain Complex ◽  
Complex Iii ◽  
Cytochrome Bc1 ◽  
Respiratory Chain Complex ◽  
Bc1 Complex ◽  
Cytochrome Bc1 Complex

scholarly journals NAD + repletion produces no therapeutic effect in mice with respiratory chain complex III deficiency and chronic energy deprivation

2018 ◽  
Vol 32 (11) ◽  
pp. 5913-5926 ◽  
Author(s):  
Janne Purhonen ◽  
Jayasimman Rajendran ◽  
Saara Tegelberg ◽  
Olli-Pekka Smolander ◽  
Eija Pirinen ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Respiratory Chain ◽  
Chain Complex ◽  
Complex Iii ◽  
Respiratory Chain Complex ◽  
Energy Deprivation

scholarly journals Mutations in CYC1, Encoding Cytochrome c1 Subunit of Respiratory Chain Complex III, Cause Insulin-Responsive Hyperglycemia

2013 ◽  
Vol 93 (2) ◽  
pp. 384-389 ◽  
Author(s):  
Pauline Gaignard ◽  
Minal Menezes ◽  
Manuel Schiff ◽  
Aurélien Bayot ◽  
Malgorzata Rak ◽  
...  
Keyword(s):  
Respiratory Chain ◽  
Chain Complex ◽  
Complex Iii ◽  
Respiratory Chain Complex ◽  
Cytochrome C1

scholarly journals Ketogenic diet attenuates hepatopathy in mouse model of respiratory chain complex III deficiency caused by a Bcs1l mutation

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Janne Purhonen ◽  
Jayasimman Rajendran ◽  
Matthias Mörgelin ◽  
Kristiina Uusi-Rauva ◽  
Shintaro Katayama ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ketogenic Diet ◽  
Respiratory Chain ◽  
Chain Complex ◽  
Complex Iii ◽  
Respiratory Chain Complex

scholarly journals Respiratory chain supercomplexes associate with the cysteine desulfurase complex of the iron–sulfur cluster assembly machinery

2018 ◽  
Vol 29 (7) ◽  
pp. 776-785 ◽  
Author(s):  
Lena Böttinger ◽  
Christoph U. Mårtensson ◽  
Jiyao Song ◽  
Nicole Zufall ◽  
Nils Wiedemann ◽  
...  
Keyword(s):  
Respiratory Chain ◽  
Complex Iii ◽  
Bc1 Complex ◽  
Cytochrome Bc1 Complex ◽  
Respiratory Chain Complexes ◽  
Cysteine Desulfurase ◽  
Complex Iv ◽  
Iron Sulfur Cluster ◽  
Iron Sulfur ◽  
Chain Complexes

Mitochondria are the powerhouses of eukaryotic cells. The activity of the respiratory chain complexes generates a proton gradient across the inner membrane, which is used by the F1FO-ATP synthase to produce ATP for cellular metabolism. In baker’s yeast, Saccharomyces cerevisiae, the cytochrome bc1 complex (complex III) and cytochrome c oxidase (complex IV) associate in respiratory chain supercomplexes. Iron–sulfur clusters (ISC) form reactive centers of respiratory chain complexes. The assembly of ISC occurs in the mitochondrial matrix and is essential for cell viability. The cysteine desulfurase Nfs1 provides sulfur for ISC assembly and forms with partner proteins the ISC-biogenesis desulfurase complex (ISD complex). Here, we report an unexpected interaction of the active ISD complex with the cytochrome bc1 complex and cytochrome c oxidase. The individual deletion of complex III or complex IV blocks the association of the ISD complex with respiratory chain components. We conclude that the ISD complex binds selectively to respiratory chain supercomplexes. We propose that this molecular link contributes to coordination of iron–sulfur cluster formation with respiratory activity.

Novel Mycotoxin fromAcremonium exuviarumIs a Powerful Inhibitor of the Mitochondrial Respiratory Chain Complex III

2009 ◽  
Vol 22 (3) ◽  
pp. 565-573 ◽  
Author(s):  
Alexey G. Kruglov ◽  
Maria A. Andersson ◽  
Raimo Mikkola ◽  
Merja Roivainen ◽  
Laszlo Kredics ◽  
...  
Keyword(s):  
Respiratory Chain ◽  
Chain Complex ◽  
Mitochondrial Respiratory Chain ◽  
Complex Iii ◽  
Respiratory Chain Complex ◽  
Mitochondrial Respiratory Chain Complex ◽  
Mitochondrial Respiratory

Respiratory chain complex III deficiency with pruritus: A novel vitamin responsive clinical feature

1999 ◽  
Vol 134 (3) ◽  
pp. 352-354 ◽  
Author(s):  
David Mowat ◽  
Denise M. Kirby ◽  
K.Ramanand Kamath ◽  
Alex Kan ◽  
David R. Thorburn ◽  
...  
Keyword(s):  
Respiratory Chain ◽  
Chain Complex ◽  
Complex Iii ◽  
Clinical Feature ◽  
Respiratory Chain Complex
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