Commentary on and reprint of Till JE, McCulloch EA, A direct measurement of the radiosensitivity of normal mouse bone marrow cells, in Radiation Research (1961) 14:213–222

Hematology ◽  
2000 ◽  
pp. 923-936 ◽  
Keyword(s):  
Bone Marrow ◽  
Direct Measurement ◽  
Normal Mouse ◽  
Bone Marrow Cells ◽  
Mouse Bone Marrow ◽  
Radiation Research ◽  
Mouse Bone Marrow Cells ◽  
Marrow Cells

scholarly journals The Cultivation of Mouse Bone Marrow in Vivo

Blood ◽  
1959 ◽  
Vol 14 (9) ◽  
pp. 1040-1046 ◽  
Author(s):  
IRWIN BERMAN ◽  
HENRY S. KAPLAN
Keyword(s):  
Bone Marrow ◽  
Peritoneal Cavity ◽  
Normal Mouse ◽  
Bone Marrow Cells ◽  
Mouse Bone Marrow ◽  
Considerable Time ◽  
Diffusion Chambers ◽  
Mouse Bone Marrow Cells ◽  
Marrow Cells

Abstract The cultivation of normal mouse bone marrow cells in diffusion chambers implanted into the peritoneal cavity of mice has been described. Mouse bone marrow cells cultivated by this method continue to undergo differentiation and maintain their morphologic identity for a considerable time.

Mechanisms associated with IL-6–induced up-regulation of Jak3 and its role in monocytic differentiation

Blood ◽  
2004 ◽  
Vol 103 (11) ◽  
pp. 4093-4101 ◽  
Author(s):  
James K. Mangan ◽  
Sushil G. Rane ◽  
Anthony D. Kang ◽  
Arshad Amanullah ◽  
Brian C. Wong ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Normal Mouse ◽  
Bone Marrow Cells ◽  
Specific Inhibitor ◽  
Janus Kinase ◽  
Mouse Bone Marrow ◽  
Monocytic Differentiation ◽  
Ectopic Overexpression ◽  
Mouse Bone Marrow Cells ◽  
Marrow Cells

Abstract We report here that Janus kinase 3 (Jak3) is a primary response gene for interleukin-6 (IL-6) in macrophage differentiation, and ectopic overexpression of Jak3 accelerates monocytic differentiation of normal mouse bone marrow cells stimulated with cytokines. Furthermore, we show that incubation of normal mouse bone marrow cells with a JAK3-specific inhibitor results in profound inhibition of myeloid colony formation in response to granulocyte-macrophage colony-stimulating factor or the combination of stem cell factor, IL-3, and IL-6. In addition, mutagenesis of the Jak3 promoter has revealed that Sp1 binding sites within a -67 to -85 element and a signal transducer and activator of transcription (Stat) binding site at position -44 to -53 are critical for activation of Jak3 transcription in murine M1 myeloid leukemia cells stimulated with IL-6. Electrophoretic mobility shift assay (EMSA) analysis has demonstrated that Sp1 can bind to the -67 to -85 element and Stat3 can bind to the -44 to -53 STAT site in IL-6-stimulated M1 cells. Additionally, ectopic overexpression of Stat3 enhanced Jak3 promoter activity in M1 cells. This mechanism of activation of the murine Jak3 promoter in myeloid cells is distinct from a recently reported mechanism of activation of the human JAK3 promoter in activated T cells.

scholarly journals Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transfer.

1987 ◽  
Vol 166 (4) ◽  
pp. 1162-1167 ◽  
Author(s):  
K L Komschlies ◽  
D L Greiner ◽  
L Shultz ◽  
I Goldschneider
Keyword(s):  
Bone Marrow ◽  
Intravenous Injection ◽  
Normal Mouse ◽  
Bone Marrow Cells ◽  
Mutant Mice ◽  
Mouse Bone Marrow ◽  
Wild Type ◽  
Intrathymic Injection ◽  
Mouse Bone Marrow Cells ◽  
Marrow Cells

Bone marrow prothymocytes from me/me and mev/mev mutant mice fail to generate thymocytes in irradiated (600 rad) +/+ wild-type recipients after intravenous injection. However, these same prothymocytes readily generate thymocytes after intrathymic injection. The results of the present study demonstrate that this apparent defect in the thymus-homing capacity of mev/mev prothymocytes can be corrected by mixing irradiated wild-type bone marrow cells with mev/mev bone marrow cells before intravenous injection. However, this defect is not corrected by passage of mev/mev bone marrow cells through the bone marrow of irradiated wild-type recipients. One interpretation of these results is that the maturation of prothymocytes is reversibly arrested in mev/mev mice by a defect in the radiosensitive compartment of the bone marrow microenvironment.

scholarly journals Brahmarasayana protects against Ethyl methanesulfonate or Methyl methanesulfonate induced chromosomal aberrations in mouse bone marrow cells

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Kanive Parashiva Guruprasad ◽  
Advait Subramanian ◽  
Vikram Jeet Singh ◽  
Raghavendra Sudheer Kumar Sharma ◽  
Puthiya Mundyat Gopinath ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Chromosomal Aberrations ◽  
Bone Marrow Cells ◽  
Ethyl Methanesulfonate ◽  
Methyl Methanesulfonate ◽  
Mouse Bone Marrow ◽  
Mouse Bone Marrow Cells ◽  
Marrow Cells

scholarly journals Hepatocyte-like cells from directed differentiation of mouse bone marrow cells in vitro1

2005 ◽  
Vol 26 (4) ◽  
pp. 469-476 ◽  
Author(s):  
Xiao-lei SHI ◽  
Yu-dong QIU ◽  
Qiang LI ◽  
Ting XIE ◽  
Zhang-hua ZHU ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Mouse Bone Marrow ◽  
Directed Differentiation ◽  
Mouse Bone Marrow Cells ◽  
Marrow Cells

Induction of micronuclei in mouse bone marrow cells: An evaluation of nucleoside analogues used in the treatment of AIDS

1991 ◽  
Vol 18 (3) ◽  
pp. 168-183 ◽  
Author(s):  
Marcia D. Phillips ◽  
Bruce Nascimbeni ◽  
Raymond R. Tice ◽  
Michael D. Shelby ◽  
A. A. Van Zeeland
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Nucleoside Analogues ◽  
Mouse Bone Marrow ◽  
Mouse Bone Marrow Cells ◽  
Marrow Cells
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