Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W

Harshica Fernando; Dmitri R. Davydov; Christopher C. Chin; James R. Halpert

doi:10.1016/j.abb.2006.12.025

Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W

Archives of Biochemistry and Biophysics ◽

10.1016/j.abb.2006.12.025 ◽

2007 ◽

Vol 460 (1) ◽

pp. 129-140 ◽

Cited By ~ 24

Author(s):

Harshica Fernando ◽

Dmitri R. Davydov ◽

Christopher C. Chin ◽

James R. Halpert

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 3A4 ◽

Subunit Interactions

Download Full-text

Role of Cytochrome P450 3A4 and 1A2 Phenotyping in Patients with Advanced Non-small-Cell Lung Cancer Receiving Erlotinib Treatment

Basic & Clinical Pharmacology & Toxicology ◽

10.1111/bcpt.12801 ◽

2017 ◽

Vol 121 (4) ◽

pp. 309-315 ◽

Cited By ~ 7

Author(s):

Zinnia P. Parra-Guillen ◽

Peter B. Berger ◽

Manuel Haschke ◽

Massimiliano Donzelli ◽

Daria Winogradova ◽

...

Keyword(s):

Lung Cancer ◽

Cytochrome P450 ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Cytochrome P450 3A4 ◽

Small Cell Lung

Download Full-text

Effects of myricetin, an antioxidant, on the pharmacokinetics of losartan and its active metabolite, EXP-3174, in rats: possible role of cytochrome P450 3A4, cytochrome P450 2C9 and P-glycoprotein inhibition by myricetin

Journal of Pharmacy and Pharmacology ◽

10.1211/jpp.62.07.0012 ◽

2010 ◽

Vol 62 (7) ◽

pp. 908-914 ◽

Cited By ~ 26

Author(s):

Dong-Hyun Choi ◽

Cheng Li ◽

Jun-Shik Choi

Keyword(s):

Cytochrome P450 ◽

Active Metabolite ◽

Cytochrome P450 3A4 ◽

Cytochrome P450 2C9 ◽

P Glycoprotein ◽

Glycoprotein Inhibition

Download Full-text

Antiplatelet Drug Resistance and Drug-Drug Interactions: Role of Cytochrome P450 3A4

Pharmaceutical Research ◽

10.1007/s11095-006-9084-4 ◽

2006 ◽

Vol 23 (12) ◽

pp. 2691-2708 ◽

Cited By ~ 33

Author(s):

Wei C. Lau ◽

Paul A. Gurbel

Keyword(s):

Drug Resistance ◽

Cytochrome P450 ◽

Drug Interactions ◽

Antiplatelet Drug ◽

Cytochrome P450 3A4 ◽

Antiplatelet Drug Resistance

Download Full-text

Clinically Important Drug Interactions Potentially Involving Mechanism-based Inhibition of Cytochrome P450 3A4 and the Role of Therapeutic Drug Monitoring

Therapeutic Drug Monitoring ◽

10.1097/ftd.0b013e31815c16f5 ◽

2007 ◽

Vol 29 (6) ◽

pp. 687-710 ◽

Cited By ~ 211

Author(s):

Shu-Feng Zhou ◽

Charlie Changli Xue ◽

Xue-Qing Yu ◽

Chunguang Li ◽

Guangji Wang

Keyword(s):

Cytochrome P450 ◽

Therapeutic Drug Monitoring ◽

Drug Interactions ◽

Drug Monitoring ◽

Therapeutic Drug ◽

Cytochrome P450 3A4 ◽

Important Drug

Download Full-text

Effects of baicalein on the pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats: Possible role of cytochrome p450 3A4 and P-glycoprotein inhibition by baicalein

Archives of Pharmacal Research ◽

10.1007/s12272-011-1117-9 ◽

2011 ◽

Vol 34 (11) ◽

pp. 1965-1972 ◽

Cited By ~ 34

Author(s):

Cheng Li ◽

Minhee Kim ◽

HongSeok Choi ◽

JunShik Choi

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 3A4 ◽

Main Metabolite ◽

P Glycoprotein ◽

Glycoprotein Inhibition

Download Full-text

Metabolic Activation of Diclofenac by Human Cytochrome P450 3A4: Role of 5-Hydroxydiclofenac

Chemical Research in Toxicology ◽

10.1021/tx9802365 ◽

1999 ◽

Vol 12 (2) ◽

pp. 214-222 ◽

Cited By ~ 123

Author(s):

Sijiu Shen ◽

Michael R. Marchick ◽

Margaret R. Davis ◽

George A. Doss ◽

Lance R. Pohl

Keyword(s):

Cytochrome P450 ◽

Metabolic Activation ◽

Cytochrome P450 3A4 ◽

Human Cytochrome

Download Full-text

Role of Enzyme Flexibility in Ligand Access and Egress to Active Site: Bias-Exchange Metadynamics Study of 1,3,7-Trimethyluric Acid in Cytochrome P450 3A4

Journal of Chemical Theory and Computation ◽

10.1021/acs.jctc.6b00075 ◽

2016 ◽

Vol 12 (4) ◽

pp. 2101-2109 ◽

Cited By ~ 30

Author(s):

Markéta Paloncýová ◽

Veronika Navrátilová ◽

Karel Berka ◽

Alessandro Laio ◽

Michal Otyepka

Keyword(s):

Cytochrome P450 ◽

Active Site ◽

Cytochrome P450 3A4

Download Full-text

Role of c-Myc in nitric oxide-mediated suppression of cytochrome P450 3A4

Life Sciences ◽

10.1016/j.lfs.2003.07.006 ◽

2003 ◽

Vol 74 (1) ◽

pp. 99-108 ◽

Cited By ~ 6

Author(s):

Masahiko Watabe ◽

Yumiko Isogai ◽

Satoshi Numazawa ◽

Takemi Yoshida

Keyword(s):

Nitric Oxide ◽

Cytochrome P450 ◽

Cytochrome P450 3A4

Download Full-text

Nefiracetam metabolism by human liver microsomes: role of cytochrome P450 3A4 and cytochrome P450 1A2 in 5-hydroxynefiracetam formation

Journal of Pharmacy and Pharmacology ◽

10.1211/0022357011776144 ◽

2001 ◽

Vol 53 (6) ◽

pp. 795-804 ◽

Cited By ~ 4

Author(s):

Yuko Fujimaki ◽

Nobuko Arai ◽

Tsunenori Nakazawa ◽

Masayoshi Fujimaki

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Cytochrome P450 3A4 ◽

Cytochrome P450 1A2

Download Full-text

Role of human cytochrome P450 3A4 and 3A5 in the metabolism of taxotere and its derivatives: enzyme specificity, interindividual distribution and metabolic contribution in human liver

Pharmacogenetics ◽

10.1097/00008571-199810000-00004 ◽

1998 ◽

Vol 8 (5) ◽

pp. 391-401 ◽

Cited By ~ 139

Author(s):

Magang Shou ◽

Michel Martinet ◽

Kenneth R. Korzekwa ◽

Kristopher W. Krausz ◽

Frank J. Gonzalez ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Cytochrome P450 3A4 ◽

Enzyme Specificity ◽

Human Cytochrome

Download Full-text