Antiplatelet Drug Resistance and Drug-Drug Interactions: Role of Cytochrome P450 3A4

2006 ◽  
Vol 23 (12) ◽  
pp. 2691-2708 ◽  
Author(s):  
Wei C. Lau ◽  
Paul A. Gurbel
Keyword(s):  
Drug Resistance ◽  
Cytochrome P450 ◽  
Drug Interactions ◽  
Antiplatelet Drug ◽  
Cytochrome P450 3A4 ◽  
Antiplatelet Drug Resistance

Predicting drug–drug interactions by electrochemically driven cytochrome P450 3A4 reactions

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Victoria V. Shumyantseva ◽  
Polina I. Koroleva ◽  
Tatiana V. Bulko ◽  
Gennady V. Sergeev ◽  
Sergei A. Usanov
Keyword(s):  
Experimental Data ◽  
Cytochrome P450 ◽  
Drug Interactions ◽  
Model Systems ◽  
Cytochrome P450 3A4 ◽  
System Method ◽  
Human Cytochrome ◽  
Driven System ◽  
Measuring Tool

Abstract Objectives Human cytochrome P450 3A4 is the most abundant hepatic and intestinal Phase I enzyme that metabolizes approximately 60% marketed drugs. Simultaneous administration of several drugs may result in appearance of drug–drug interaction. Due to the great interest in the combination therapy, the exploration of the role of drug as “perpetrator” or “victim” is important task in pharmacology. In this work the model systems based on electrochemically driven cytochrome P450 3A4 for the analysis of drug combinations was used. We have shown that the analysis of electrochemical parameters of cytochrome P450 3A4 and especially, potential of the start of catalysis, Eonset, possess predictive properties in the determination of the leading (“perpetrator”) properties of drug. Based on these experimental data, we concluded, that the more positive potential of the start of catalysis, Eonset, the more pronounced the role of drug as leading medication. Methods Electrochemically driven cytochrome P450 3A4 was used as probe and measuring tool for the estimation of the role of interacting drugs. Results It is shown that the electrochemical non-invasive model systems for monitoring the catalytic activity of cytochrome P450 3A4 can be used as prognostic devise in assessment of drug/drug interacting medications. Conclusions Cytochrome P450 3A4 activity was studied in electrochemically driven system. Method was implemented to monitor drug/drug interactions. Based on the obtained experimental data, we can conclude that electrochemical parameter such as potential of onset of catalysis, Eonset, has predictive efficiency in assessment of drug/drug interacting medications in the case of the co-administration.

scholarly journals Role of Cytochrome P450 3A4 and 1A2 Phenotyping in Patients with Advanced Non-small-Cell Lung Cancer Receiving Erlotinib Treatment

2017 ◽  
Vol 121 (4) ◽  
pp. 309-315 ◽  
Author(s):  
Zinnia P. Parra-Guillen ◽  
Peter B. Berger ◽  
Manuel Haschke ◽  
Massimiliano Donzelli ◽  
Daria Winogradova ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cytochrome P450 ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Cytochrome P450 3A4 ◽  
Small Cell Lung

scholarly journals Chimeric cytochrome P450 3A4 used for in vitro prediction of food–drug interactions

2020 ◽  
Vol 67 (4) ◽  
pp. 541-548 ◽  
Author(s):  
Sheila J. Sadeghi ◽  
Giovanna Di Nardo ◽  
Gianfranco Gilardi
Keyword(s):  
Cytochrome P450 ◽  
Drug Interactions ◽  
Cytochrome P450 3A4
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