Herbal Medicine in Children With Respiratory Tract Infection: Systematic Review and Meta-Analysis

Background Cystic fibrosis (CF) is a genetic disorder in which the respiratory system gets clogged with mucus leads to progressive lung damage. There is no known cure for CF but several treatments to manage symptoms and reduce complications. Vitamin D deficiency is common in CF associated with increased infection and inflammation. This systematic review and meta analysis will evaluate the effectiveness of vitamin D treatment in reducing respiratory tract infection and inflammation in patients with CF. Methods Randomized and quasi randomised studies in CF patients with control groups will be identified. The antibacterial activity of vitamin D supplementation will help in reducing respiratory tract infection and inflammation in CF. Overall effects of vitamin D in terms of infection and inflammatory markers such as C reactive protein, inflammatory cytokine interleukin (IL)6, IL8, IL17, IL23, antimicrobial peptide (LL37), lung function defined by forced expiratory volume in 1 second (FEV1)%, other assessed respiratory parameters will be calculated using random-effect models. Study quality will be assessed using RoB 2, A revised Cochrane Risk of Bias tool for randomised trials. The overall quality of evidence for each outcome will be summarised according to the Grading of Recommendations Assessment, Development, and Evaluations (GRADE) framework.

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The Prevalence of Healthcare-Associated Infections in Mainland China: A Systematic Review and Meta-analysis

Infection Control and Hospital Epidemiology ◽

10.1017/ice.2018.60 ◽

2018 ◽

Vol 39 (6) ◽

pp. 701-709 ◽

Cited By ~ 19

Author(s):

Jiancong Wang ◽

Fangfei Liu ◽

Ermira Tartari ◽

Jianan Huang ◽

Stephan Harbarth ◽

...

Keyword(s):

Systematic Review ◽

Tract Infection ◽

Respiratory Tract ◽

Respiratory Tract Infection ◽

Acute Care ◽

Meta Analysis ◽

Mainland China ◽

Healthcare Associated Infections ◽

General Hospitals ◽

Healthcare Associated

OBJECTIVETo assess the prevalence of healthcare-associated infections (HAIs) in mainland China.DESIGNSystematic review and meta-analysis.SETTINGAdults and children from secondary and tertiary acute-care hospitals in mainland China.METHODSWe searched PubMed, the China National Knowledge Infrastructure, and Wan Fang for multicenter point-prevalence surveys of acute-care hospitals in mainland China from January 2006 to August 2016. All reports related to HAI, using a point-prevalence methodology and published either in English or Chinese were eligible.RESULTSIn total, 3,021 publications were identified; 115 were eligible for quality assessment and data abstraction. The weighted HAI prevalence (95% confidence interval [CI]) overall, in general hospitals, children’s hospitals, maternal and child health hospitals, and oncology hospitals were 3.12% (95% CI, 2.94%–3.29%), 3.02% (95% CI, 2.79%–3.26%), 4.43% (95% CI, 3.39%–5.47%), 1.88% (95% CI, 1.47%–2.29%), and 3.96% (95% CI, 3.12%–4.79%), respectively. In general hospitals, prevalence was highest in adult intensive care units (26.07%; 95% CI, 23.03%–29.12%), followed by surgery (3.26%; 95% CI, 2.96%–3.57%), and internal medicine (3.06%; 95% CI, 2.67%–3.46%). Overall, lower respiratory tract infection was the most frequent HAI (24,185, 47.28%), followed by urinary tract infection (5,773, 11.29%) and upper respiratory tract infection (5,194, 10.15%). Gram-negative bacilli were the most frequently isolated pathogens, and Pseudomonas aeruginosa (3,395, 14.91%), and Escherichia coli (2,918, 12.82%) were the most common single microorganisms.CONCLUSIONSThis study is the largest systematic review on the prevalence of HAI in mainland China. These results provide a benchmark for future PPSs and a reference for infection prevention and control strategies in mainland China.Infect Control Hosp Epidemiol 2018;39:701–709

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