Vitamin D
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2021 ◽  
Zi yu Gao ◽  
Zhan hao Chang ◽  
Tian Song ◽  
Dong fan Liu ◽  
Xin Li ◽  

Abstract Fibromyalgia (FM) is a confounding factor for diagnosing and assessing rheumatic disease activity. This study sought to assess the extent of this syndrome in rheumatoid arthritis (RA) patients at our rheumatology department. The RA patients were divided into 2 groups (RA with FM and RA without FM) according to the score of the FiRST questionnaire and modified 2016 criteria for FM. We compared the clinical data and disease activities of RA patients with and without FM. As a result, RA patients with FM showed higher levels of CRP, ESR, DAS28-ESR compared with RA patients without FM in both FiRST questionnaires and questionnaires developed to diagnose FM(2016 criteria).Furthermore, RA patients with FM showed higher levels of IgA compared to without FM. For the blood cells count, RA patients with FM showed higher levels of white blood cells, platelets and lower levels of hemoglobin compared with RA patients without FM. Only by FiRST Questionnaires, RA patients with FM showed higher levels of RF compared to without FM. However, all groups showed a similar pattern in anti-CCP and IgG, IgM. RA patients with FM showed lower levels of vitamin D (VD) and higher levels of interleukin (IL)-6 compared with RA patients without FM.In conclusion,FM is a common feature in RA, more associated with high values of disease activity such as ESR, CRP and DAS28-ESR.

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261097
Max Mimpen ◽  
Linda Rolf ◽  
Geert Poelmans ◽  
Jody van den Ouweland ◽  
Raymond Hupperts ◽  

Introduction A poor 25-hydroxyvitamin D (25(OH)D) status is a much replicated risk factor for developing multiple sclerosis (MS), and several vitamin D-associated single nucleotide polymorphisms (SNPs) have been associated with a higher risk of MS. However, studies on the benefit of vitamin D supplementation in MS show inconclusive results. Here, we explore whether vitamin D-associated SNPs and MS risk alleles confound serological response to vitamin D supplementation. Methods 34 participants from the SOLARIUM study consented to genotyping, of which 26 had vitamin D data available. The SOLARIUM study randomised relapsing-remitting MS patients to placebo or 14,000 IU vitamin D3 for 48 weeks. Participants were categorised as either ‘carriers’ or ‘non-carriers’ of the risk allele for 4 SNPs: two related to D binding protein (DBP) and associated with lower 25(OH)D levels (rs4588 and rs7041), and two related to vitamin D metabolism enzymes CYP27B1 and CYP24A1 and associated with a higher risk of MS (rs12368653; rs2248359, respectively). 25(OH)D levels were determined at baseline and after 48 weeks. Results The DBP-related SNPs showed no difference in 25(OH)D status at baseline, but carriers of the rs7041 risk allele showed lower 25(OH)D-levels compared to non-carriers after 48 weeks of supplementation (median 224.2 vs. 332.0 nmol/L, p = 0.013). For CYP related SNPs, neither showed a difference at baseline, but carriers of the rs12368653 risk allele showed higher 25(OH)D-levels compared to non-carriers after 48 weeks of supplementation (median 304.1 vs. 152.0 nmol/L, p = 0.014). Discussion Vitamin D-related SNPs affect the serological response to high-dose vitamin D supplementation. The effects on more common doses of vitamin D, as well as the clinical consequence of this altered response, need to be investigated further.

2021 ◽  
Vol 1 (30) ◽  
pp. 24-29
A. V. Solomennikov ◽  
S. L. Bogdanova ◽  
A. I. Tyukavin ◽  
N. A. Arsenyev

The authors used the proposed method of mathematical and statistical processing of laboratory data (indicators of electrolyte metabolism and osteomarkers) of archived data of 82 patients with various bone diseases aged 9.90 ± 0.55 years compared the structural changes in the panel of ratios of individual electrolytes and the influence of individual indicators on them in personalized data, on the basis of which a conclusion was made about a single mechanism of coinciding influences in the exchange of bone tissue. At the same time, it was found that the complex of associated links detected by the vitamin influence on the panel of electrolyte ratios may differ signifcantly in some cases from each other. These differences consisted in highly pronounced differences in the activity of vitamin D in relation to various components of osteosynthesis and osteolysis, which are described in the modern literature. On this basis, the authors conclude that the used method (analytical system) allows to identify the functional connections of the dynamics of the indicator of vitamin D in individual cases with the dynamics of other indicators of bone, which signifcantly expands the informativeness of the results of laboratory examination of the patient in determining the leading systems the implementation of functional activity of the vitamin. The presented results justify the possibility of creating and describing different images of vitamin D-related changes in the plasma electrolyte composition, followed by their use in the identifcation of certain disorders of calcium metabolism and/or evaluating the effectiveness of the therapy used in each individual case.

Stine Weder ◽  
Markus Keller ◽  
Morwenna Fischer ◽  
Katja Becker ◽  
Ute Alexy

Abstract Purpose There is an ongoing debate whether vegetarian (VG) and especially vegan (VN) diets are nutritionally adequate in early childhood. Hence, the Vegetarian and Vegan Children Study (VeChi Diet Study) aimed to assess the food and nutrient intake of VG and VN infants. Methods The study examined the diets of 1–3-year-old VG, VN, and omnivorous (OM) children (n = 430). Dietary intake was assessed via a 3-day weighed dietary record and compared between groups using ANCOVA. Lifestyle data were collected using a questionnaire. Here, the results of micronutrient and fatty acid intakes are presented. Results Most nutrient intakes (with and without supplements) differed significantly between VN children and the two other groups, with a more favourable overall micronutrient intake in VN, followed by VG children, [e.g., the highest intake of vitamin E (8.3 mg/d vs. VG 7.4 mg/d and OM 5.1 mg/d), vitamin B1 (569 µg/d vs. VG 513 µg/d and OM 481 µg/d), folate (143 µg/d vs. VG 116 µg/d and OM 108 µg/d), magnesium (241 mg/d vs. VG 188 mg/d and OM 164 mg/d), and iron (8.9 mg/d vs. VG 7.3 mg/d and OM 6.0 mg/d)] as well as fat quality [highest intake of polyunsaturated fatty acids (8.7 E% vs. VG 6.9 E% and OM 4.5 E%) and lowest intake of saturated fatty acids (9.1 E% vs. VG 11.9 E% and OM 14.0 E%)]. In contrast, OM children had the highest intake of vitamin B2 (639 µg/d vs. VG 461 µg/d and VN 429 µg/d), calcium (445 mg/d vs. VG 399 mg/d and VN 320 mg/d), iodine (47 µg/d vs. VG 33 µg/d and VN 31 µg/d), and DHA (35.4 mg/d vs. VG 16.6 mg/d and VN 18.4 mg/d). Without supplementation, OM children had the highest average vitamin B12 intake (1.5 µg/d vs. VG 0.6 µg/d and VN 0.2 µg/d), whereas VN children had the highest average vitamin B12 intake with supplementation (73.8 µg/d vs. VG 1.3 µg/d and OM 1.7 µg/d). Without supplementation, none of the groups’ median intakes met the harmonised Average Requirement (h-AR) for vitamin D and iodine. Moreover, VG and VN children did not achieve h-ARs for vitamin B2, vitamin B12, and iron—if a low absorption of iron is anticipated; VN children also did not do so for calcium. Conclusion In early childhood, VN and VG diets can provide most micronutrients in desirable amounts and a preferable fat quality compared to an OM diet. Special focus should be paid to (potentially) critical nutrients, particularly vitamin D, iodine, and DHA for all children regardless of diet, as well as vitamin B2, vitamin B12, calcium, and iron for VG and VN children. Trail registration This study was registered with the German Clinical Trials Register (DRKS00010982) on (September 2, 2016).

2021 ◽  
Vol 8 ◽  
Jiejie Tao ◽  
Feiling Lou ◽  
Yuntao Liu

Introduction: Accumulating evidence had demonstrated that females had a higher risk of deep vein thrombosis (DVT) than males, but the mechanism was still unknown. Vitamin D was found to play an essential role in DVT, and gender may influence the serum vitamin D levels. This study aimed to explore whether vitamin D played a role in the gender difference in DVT.Materials and Methods: A total of 444 patients with acute stroke were recruited, which were divided into the DVT group (n = 222) and the non-DVT group (n = 222). Serum vitamin D levels were measured after admission and were split into three categories, including deficiency (<50 nmol/L), insufficiency (52.5–72.5 nmol/L), and sufficiency (more than 75 nmol/L). Hierarchical regression analysis was adopted to analyze the relationship between gender and DVT, controlling the confounding factors.Results: Females showed a higher proportion of DVT than males (60.7 vs. 42.5%, p < 0.001), and lower serum vitamin D levels than males (53.44 ± 16.45 vs. 69.43 ± 23.14, p < 0.001). Moreover, serum vitamin D levels were lower in the DVT group than in the non-DVT group (59.44 ± 19.61 vs. 66.24 ± 23.86, p < 0.001). Besides, the DVT group showed a lower proportion of vitamin D sufficiency than the non-DVT group (21.2 vs. 32.9%, p < 0.05). Hierarchical regression analysis showed that females had 2.083-fold (p < 0.001, unadjusted model) and 1.413-fold (p = 0.155, adjusted model) risk to develop DVT. In addition, the sufficiency status of vitamin D showed an independent protective effect on DVT (unadjusted model OR, 0.504, p = 0.004; adjusted model OR, 0.686, p = 0.011).Conclusion: Females had a higher risk of DVT than males, and vitamin D may play an essential role in this relationship. Further studies are needed to explore whether vitamin D supplementation could reduce DVT risk in stroke patients, especially females.

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Lucy N. W. Mungai ◽  
Zanuba Mohammed ◽  
Michuki Maina ◽  
Omar Anjumanara

Vitamin D is an important hormone that is known for the regulation of calcium and phosphate metabolism. Vitamin D deficiency leads to rickets in children and osteoporosis in adults leading to poor bone mineralisation and can also lead to serious dental complications in the same population. Recent studies have shown vitamin D to work as a hormone needed not only in bone and teeth but also in other body organs from intrauterine life up to old age. It has been demonstrated that Vitamin D has various effects on biological processes that deal with cell growth, differentiation, cell death, immune regulation, DNA stability, and neuronal growth. Despite being readily formed in the body through the intervention of the sun, patients are still found to have low vitamin D levels. We review studies done to show how vitamin D works.

2021 ◽  
Vol 12 ◽  
Tian-Ping Zhang ◽  
Hong-Miao Li ◽  
Qian Huang ◽  
Li Wang ◽  
Xiao-Mei Li

Abnormal vitamin D metabolism is involved in the pathogenesis of rheumatoid arthritis (RA). In this study, we evaluated the association of single nucleotide polymorphisms (SNPs) and methylation levels in vitamin D metabolic pathway genes with RA susceptibility. Ten SNPs in vitamin D metabolic pathway genes (CYP2R1, CYP24A1, VDR, CYP27B1) were genotyped in 477 RA patients and 496 controls by improved multiple ligase detection reaction (iMLDR). The methylation levels of the promoter regions of these genes were detected in 122 RA patients and 123 controls using Illumina Hiseq platform. We found that the CYP2R1 rs1993116 GA genotype, CYP27B1 rs4646536 GA genotype, rs4646536 A allele frequencies were significantly increased in RA patients when compared to controls. The decreased risk of rs1993116, rs4646536 was found under the dominant mode in RA patients. However, no significant association was found between CYP2R1 rs7936142, rs12794714, CYP24A1 rs2762934, rs6068816, rs2296239, rs2296241, VDR rs11574129, rs3847987 polymorphism, and RA susceptibility. The VDR, CYP27B1 methylation levels in RA patients were significantly lower than those in controls, while CYP2R1, CYP24A1 methylation levels were not associated with RA. There were no statistical associations between CYP2R1, CYP24A1, VDR, CYP27B1 methylation levels and their respective genotype in RA patients. In addition, plasma 25OHD level in RA patients was significantly lower than that in healthy controls. In summary, our results showed that CYP2R1, CYP27B1 genetic variations were associated with the genetic background of RA, while altered VDR, CYP27B1 methylation levels were related to the risk of RA.

Наталия Александровна Полушкина ◽  
Наталия Владимировна Чиркова ◽  
Жанна Владимировна Вечеркина ◽  
Кристина Павловна Кубышкина ◽  
Марина Николаевна Бобешко

Витамин Д является жирорастворимым витамином, который в организме человека вырабатывается только при определённых условиях, когда ультрафиолетовые лучи солнечного света попадают на кожу человека. В организм человека витамин Д поступает в ограниченном количестве 20- 30% от потребности , в таких продуктах питания как: лосось(200-800 МЕ на 100 г), сметана-50 МЕ, печень говяжья-45МЕ, масло сливочное-10-150 МЕ, молоко, обогащённое витамином Д, желтки яиц-45 МЕ. Витамину Д для активации в организме необходимо пройти два процесса гидроксилирования. Первый из них происходит в печени (до 90%) и превращает витамин Д в 25-гидроксивитамин Д-25(ОН)Д или кальцидиол. Второй этап происходит в почках (10%), в результате чего синтезируется активный 1,25 -дигидроксивитамин Д или кальцитриол. Уровень образования Д-гормона в организме взрослого человека составляет около 0,3-1,0 мкг/сут. Важнейшая реакция, в которой участвует витамин Д - абсорбция кальция в кишечнике и его реабсорбция в почках, поддержание необходимого уровня кальция и фосфатов в крови, он необходим для роста костей и процессов костного ремоделирования. Чтобы сохранить нормальный гомеостаз кальция и костного ремоделирования, организму необходимо получать витамин D3. В условиях физиологии его потребность варьирует в сутки от двухсот-четырёхсот МЕ (у взрослых людей), до шестисот-восьмисот МЕ (у людей пожилого возраста) и до одной тысячи МЕ у лиц, живущих в районах Крайнего Севера. Концентрация промежуточного метаболита [25-(OH)D3] в сыворотке крови считается самым надёжным показателем общего обмена витамина D, поэтому этот показатель может быть использован для определения обеспеченности организма витамином D. Также он необходим для выяснения причин патологических концентраций кальция в сыворотке крови пациентов. Адекватное содержание [25-(OH)D3] поддерживает абсорбцию кальция и костный метаболизм. Содержание же [25-(OH)D3] ниже целевого значения 30 нг/мл вызывает снижение кальция в плазме крови и повышение секреции ПТГ, и как следствие, остеокластическую резорбцию кости, нарушение процессов ремоделирования и минерализации костной ткани, снижение её плотности и изменение костной архитектуры Vitamin D is a fat-soluble vitamin that is produced in the human body only under certain conditions, when ultraviolet rays of sunlight fall on the human skin. The human body receives vitamin D in a limited amount of 20-30% of the need, in such food products as: salmon (200-800 IU per 100 g), sour cream-50 IU, beef liver-45 IU, butter-10-150 IU, milk enriched with vitamin D, egg yolks-45 IU. Vitamin D needs to undergo two hydroxylation processes to be activated in the body. The first of these occurs in the liver (up to 90%) and converts vitamin D to 25-hydroxyvitamin D-25(OH)D or calcidiol. The second stage occurs in the kidneys (10%), resulting in the synthesis of active 1,25 -dihydroxyvitamin D or calcitriol. The level of D-hormone formation in the adult body is about 0.3-1.0 mcg/day. The most important reaction in which vitamin D is involved is the absorption of calcium in the intestine and its reabsorption in the kidneys, maintaining the necessary level of calcium and phosphates in the blood, it is necessary for bone growth and bone remodeling processes. To maintain normal calcium homeostasis and bone remodeling, the body needs to receive vitamin D3. In the conditions of physiology, its need varies per day from two hundred to four hundred IU (in adults), to six hundred to eight hundred IU (in the elderly) and up to one thousand IU in people living in the Far North. The concentration of the intermediate metabolite [25-(OH)D3] in the blood serum is considered the most reliable indicator of the total vitamin D metabolism, so this indicator can be used to determine the body's vitamin D supply. It is also necessary to find out the causes of abnormal concentrations of calcium in the blood serum of patients. Adequate [25-(OH)D3] content supports calcium absorption and bone metabolism. The content of [25-(OH)D3] below the target value of 30 ng / ml causes a decrease in calcium in the blood plasma and an increase in PTH secretion, and as a result, osteoclastic bone resorption, a violation of the processes of bone remodeling and mineralization, a decrease in its density and a change in bone architecture

2021 ◽  
Vol 15 ◽  
S Gandini ◽  
PF Ferrucci ◽  
H Johanson ◽  
B Bonanni ◽  
A Testori

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