DMPK and Metabolism Studies of Nucleoside Phosphoramidates Including INX-08189, A Novel Double Pro-drug and Clinical Candidate for Hepatitis C Virus Therapy

2011 ◽  
Vol 90 (2) ◽  
pp. A22-A23 ◽  
Author(s):  
Jeff T. Hutchins ◽  
Christopher McGuigan ◽  
Stanley D. Chamberlain ◽  
Karolina W. Madela ◽  
Mohamed Aljarah ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Nucleoside Phosphoramidates ◽  
Clinical Candidate

Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320

2015 ◽  
Vol 25 (22) ◽  
pp. 5427-5436 ◽  
Author(s):  
Christophe C. Parsy ◽  
François-René Alexandre ◽  
Valérie Bidau ◽  
Florence Bonnaterre ◽  
Guillaume Brandt ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protease Inhibitor ◽  
Serine Protease ◽  
Structural Diversity ◽  
Serine Protease Inhibitor ◽  
Clinical Candidate

Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus

2010 ◽  
Vol 20 (16) ◽  
pp. 4850-4854 ◽  
Author(s):  
Christopher McGuigan ◽  
Karolina Madela ◽  
Mohamed Aljarah ◽  
Arnaud Gilles ◽  
Andrea Brancale ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Design Synthesis ◽  
Clinical Candidate

HEPATITIS C VIRUS INFECTION (AND ADDITIONAL NEOPLASMS) AMONG MARGINAL ZONE LYMPHOMAS

1997 ◽  
Vol 96 (2) ◽  
pp. 427-428 ◽  
Author(s):  
FREDERICO SILVESTRI ◽  
GIOVANNI BARILLARI ◽  
RENATO FANIN ◽  
FLAVIA SALMASO ◽  
LAURA INFANTI ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Marginal Zone ◽  
Hepatitis C Virus Infection

Public health challenges in hepatitis C virus infection

2000 ◽  
Vol 15 (5 (Suppl.)) ◽  
pp. E83-E90 ◽  
Author(s):  
John M Kaldor ◽  
Gregory J Dore ◽  
Patricia Kl Correll
Keyword(s):  
Public Health ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Hepatitis C Virus Infection ◽  
Public Health Challenges

Expression of CD81, am ligand for hepatitis C virus (HCV) is increased on CD5+ B-lymphocytes but may not be the receptor for internalisation of HCV

2001 ◽  
Vol 120 (5) ◽  
pp. A552-A552
Author(s):  
M CURRY ◽  
T DEIGNAN ◽  
P COSTELLO ◽  
L GOLDENMASON ◽  
M DUFFY ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Lymphocytes

Analysis of interferon signal expression in hepatitis C virus-infected patients' lymphocytes

2001 ◽  
Vol 120 (5) ◽  
pp. A570-A570
Author(s):  
T TANAKA ◽  
K ASAO ◽  
K INOUE ◽  
K KOHARATSUKIYAMA ◽  
M KOHARA
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C
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