Spinal Cord Early Ischemic Preconditioning Activates the Stabilized Fraction of β-Catenin After Thoracoabdominal Aortic Occlusion in Pigs

2013 ◽  
Vol 27 (4) ◽  
pp. 480-486 ◽  
Author(s):  
Ioanna E. Kyrou ◽  
John C. Papakostas ◽  
Elli Ioachim ◽  
Urania Skoufi ◽  
Vasilios Koulouras ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Ischemic Preconditioning ◽  
Aortic Occlusion

Rapid Ischemic Preconditioning with a Short Reperfusion Time Prevents Delayed Paraplegia in a Rabbit Model

2011 ◽  
Vol 14 (5) ◽  
pp. 317
Author(s):  
Mehmet Ozkokeli ◽  
Mehmet Ugur Es ◽  
Ugur Filizcan ◽  
Murat Ugurlucan ◽  
Ahmet Sasmazel ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Ischemic Preconditioning ◽  
Spinal Cord Ischemia ◽  
Rabbit Model ◽  
Aortic Aneurysms ◽  
Aortic Occlusion ◽  
Control Group ◽  
Protective Mechanisms ◽  
Group 13 ◽  
Histologic Evaluation

<p><b>Background:</b> Surgery for thoracic and thoracoabdominal aortic aneurysms can be complicated by a significant incidence of neurogenic deficits due to spinal cord ischemia. In this study, we investigated whether ischemic preconditioning (IPC) improves neurologic outcome in a rabbit model.</p><p><b>Methods:</b> Forty rabbits underwent infrarenal aortic occlusion. The IPC group (n = 20) had 10 minutes of aortic occlusion to induce spinal cord ischemia, 40 minutes of reperfusion, and 30 minutes of ischemia, whereas the control group (n = 20) had only 30 minutes of ischemia. Tarlov scoring (0, paraplegia; 4, normal) was used to evaluate neurologic functions 7 days later, and spinal cord segments (L4-L6) were stained with hematoxylin and eosin for histologic evaluation.</p><p><b>Results:</b> Complete paraplegia (grade 0) occurred in 15 (75%) of the 20 control animals, whereas in the IPC group, 13 (65%) of 20 animals were completely normal (grade 4) (<i>P</i> < .05).</p><p><b>Conclusion:</b> IPC is beneficial for protecting against neurologic damage after transient aortic occlusion in a rabbit model; however, the protective mechanisms are not clear.</p>

scholarly journals Early ischemic preconditioning without hypotension prevents spinal cord injury caused by descending thoracic aortic occlusion

2003 ◽  
Vol 125 (5) ◽  
pp. 1030-1036 ◽  
Author(s):  
Ioannis K. Toumpoulis ◽  
Constantine E. Anagnostopoulos ◽  
George E. Drossos ◽  
Vassiliki D. Malamou-Mitsi ◽  
Lina S. Pappa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Ischemic Preconditioning ◽  
Aortic Occlusion ◽  
Cord Injury

scholarly journals Superiority of early relative to late ischemic preconditioning in spinal cord protection after descending thoracic aortic occlusion

2004 ◽  
Vol 128 (5) ◽  
pp. 724-730 ◽  
Author(s):  
Ioannis K. Toumpoulis ◽  
John C. Papakostas ◽  
Miltiadis I. Matsagas ◽  
Vassiliki D. Malamou-Mitsi ◽  
Lina S. Pappa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Ischemic Preconditioning ◽  
Aortic Occlusion ◽  
Spinal Cord Protection

scholarly journals Does ischemic preconditioning reduce spinal cord injury because of descending thoracic aortic occlusion?

2003 ◽  
Vol 37 (2) ◽  
pp. 426-432 ◽  
Author(s):  
Ioannis K. Toumpoulis ◽  
Constantine E. Anagnostopoulos ◽  
George E. Drossos ◽  
Vassiliki D. Malamou-Mitsi ◽  
Lina S. Pappa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Ischemic Preconditioning ◽  
Aortic Occlusion ◽  
Cord Injury

Neuroprotective Effect of Epidural Electrical Stimulation against Ischemic Spinal Cord Injury in Rats

2005 ◽  
Vol 103 (1) ◽  
pp. 84-92 ◽  
Author(s):  
Manabu Kakinohana ◽  
Hideki Harada ◽  
Yasunori Mishima ◽  
Tatsuhiko Kano ◽  
Kazuhiro Sugahara
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Electrical Stimulation ◽  
Neuroprotective Effect ◽  
Spinal Cord Ischemia ◽  
Aortic Occlusion ◽  
Cord Injury ◽  
Optimal Setting ◽  
Transient Aortic Occlusion ◽  
Ischemic Spinal Cord Injury

Background Electroconvulsion therapy is likely to serve as an effective preconditioning stimulus for inducing tolerance to ischemic brain injury. The current study examines whether electrical stimuli on the spinal cord is also capable of inducing tolerance to ischemic spinal cord injury by transient aortic occlusion. Methods Spinal cord ischemia was induced by occlusion of the descending thoracic aorta in combination with maintaining systemic hypotension (40 mmHg) during the procedure. Animals implanted with epidural electrodes were divided into four groups according to electrical stimulation and sham. Two groups consisted of rapid preconditioning (RE group, n = 8) and sham procedure (RC group, n = 8) 30 min before 9 min of spinal cord ischemia. In the two groups that underwent delayed preconditioning, rats were exposed to 9 min of aortic occlusion 24 h after either pretreatment with epidural electrical stimulation (DE group, n = 8) or sham (DC group, n = 8). In addition, rats were exposed to 6-11 min of spinal cord ischemia at 30 min or 24 h after epidural electrical stimulation or sham stimulation. The group P50 represents the duration of spinal cord ischemia associated with 50% probability of resultant paraplegia. Results Pretreatment with electrical stimulation in the DE group but not the RE group protected the spinal cord against ischemia, and this stimulation prolonged the P50 by approximately 15.0% in the DE group compared with the DC group. Conclusions Although the optimal setting for this electrical preconditioning should be determined in future studies, the results suggest that epidural electrical stimulation will be a useful approach to provide spinal protection against ischemia.

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