scholarly journals The translocator protein (peripheral benzodiazepine receptor) mediates rat-selective activation of the mitochondrial permeability transition by norbormide

2011 ◽  
Vol 1807 (12) ◽  
pp. 1600-1605 ◽  
Author(s):  
Alessandra Zulian ◽  
Justina Šileikytė ◽  
Valeria Petronilli ◽  
Sergio Bova ◽  
Federica Dabbeni-Sala ◽  
...  
Keyword(s):  
Mitochondrial Permeability Transition ◽  
Permeability Transition ◽  
Benzodiazepine Receptor ◽  
Translocator Protein ◽  
Peripheral Benzodiazepine Receptor ◽  
Selective Activation ◽  
Mitochondrial Permeability

Guwiyang Wurra–‘Fire Mouse’: a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies

2015 ◽  
Vol 43 (4) ◽  
pp. 553-558 ◽  
Author(s):  
Ryan J. Middleton ◽  
Guo-Jun Liu ◽  
Richard B. Banati
Keyword(s):  
Mitochondrial Permeability Transition ◽  
Gene Knockout ◽  
Physiological Role ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Benzodiazepine Receptor ◽  
Translocator Protein ◽  
Loss Of Function ◽  
Recent Developments

The highly conserved 18-kDa translocator protein (TSPO) or peripheral benzodiazepine receptor (PBR), is being investigated as a diagnostic and therapeutic target for disease conditions ranging from inflammation to neurodegeneration and behavioural illnesses. Many functions have been attributed to TSPO/PBR including a role in the mitochondrial permeability transition pore (MPTP), steroidogenesis and energy metabolism. In this review, we detail the recent developments in determining the physiological role of TSPO/PBR, specifically based on data obtained from the recently generated Tspo knockout mouse models. In addition to defining the role of TSPO/PBR, we also describe the value of Tspo knockout mice in determining the selectivity, specificity and presence of any off-target effects of TSPO/PBR ligands.

770 Preconditioning delays Ca2+-induced mitochondrial permeability transition

2003 ◽  
Vol 2 (1) ◽  
pp. 167 ◽  
Author(s):  
L ARGAUD ◽  
O GATEAUROESCH ◽  
D MUNTEAN ◽  
L GOMEZ ◽  
L CHALABREYSSE ◽  
...  
Keyword(s):  
Mitochondrial Permeability Transition ◽  
Permeability Transition ◽  
Mitochondrial Permeability
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