scholarly journals Noninvasive Measurement of Liver Fibrosis Using Transient Elastography in Pediatric Patients with Major Thalassemia Who Are Candidates for Hematopoietic Stem Cell Transplantation

2014 ◽  
Vol 20 (12) ◽  
pp. 1912-1917 ◽  
Author(s):  
Amir Ali Hamidieh ◽  
Babak Shazad ◽  
Mohammad Reza Ostovaneh ◽  
Maryam Behfar ◽  
Sirous Tayebi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Liver Fibrosis ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Pediatric Patients ◽  
Transient Elastography ◽  
Noninvasive Measurement ◽  
Hematopoietic Stem

scholarly journals Refractory ascites with liver fibrosis developed in late phase allogeneic hematopoietic stem cell transplantation: report of three patients

2016 ◽  
Vol 8 (2) ◽  
Author(s):  
Hiroki Hosoi ◽  
Kenji Warigaya ◽  
Shogo Murata ◽  
Toshiki Mushino ◽  
Kodai Kuriyama ◽  
...  
Keyword(s):  
Stem Cell ◽  
Liver Fibrosis ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Late Phase ◽  
Refractory Ascites ◽  
Hematopoietic Stem ◽  
Hepatic Atrophy

We report cases of three patients of refractory ascites without other fluid retention that occurred around five months after allogeneic hematopoietic stem cell transplantation (allo- HSCT). All three patients expired and postmortem examinations revealed unexpected liver fibrosis lacking histological evidences of graft-<em>versus</em>-host-disease (GVHD). The three patients showed normal hepatic function and size before transplantation. During their clinical courses, serum biochemistry test showed no elevation of hepatic enzymes and bilirubin; however, imaging studies demonstrated hepatic atrophy at the onset of ascites. One of the liver specimens showed bile obstruction, which could be seen in hepatic damage by GVHD. Although ascites resulting from venoocclusive disease in early phase allo-HSCT is well documented, ascites associated with hepatic fibrosis in late phase allo-HCST has not been reported. Further clinico-pathological studies on similar patients should be required to ascertain refractory ascites associated with liver fibrosis after allo-HSCT.

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