Unconditioned response to an aversive stimulus as predictor of response to conditioned fear and safety: A cross-species study

2021 ◽  
pp. 113105
Author(s):  
Judith C. Kreutzmann ◽  
Marie-France Marin ◽  
Markus Fendt ◽  
Mohammed R. Milad ◽  
Kerry Ressler ◽  
...  
2018 ◽  
Vol 31 (1) ◽  
pp. 46-51
Author(s):  
S. Melker Hagsäter ◽  
Johan Thorén ◽  
Robert Pettersson ◽  
Elias Eriksson

AbstractObjectiveWhereas long-term administration of selective serotonin reuptake inhibitors (SSRIs) is effective for the treatment of anxiety disorders, acute administration of these drugs may exert a paradoxical anxiogenic effect. The aim of the present study was to explore the possible effect of an SSRI in situations of unconditioned or limited conditioned fear.MethodsMale Sprague Dawley rats were administered a single dose of an SSRI, escitalopram, before acquisition or expression of context conditioned fear, where noise bursts were used as the unconditioned stimulus. Freezing was assessed as a measure of unconditioned fear (=the acute response to noise bursts) or conditioned fear (=the response to the context), respectively.ResultsNoise bursts elicited an acute increase in freezing but no robust conditioned response 7 days after exposure. Administration of escitalopram before testing exacerbated the freezing response during presentation of the unconditioned stimulus and also unmasked a conditioned response; in contrast, administration of escitalopram prior to acquisition did not influence the conditioned response.ConclusionThe data suggest that freezing in rats exposed to a stimulus inducing relatively mild fear may be enhanced by acute pretreatment with an SSRI regardless of whether the freezing displayed by the animals is an acute unconditioned response to the stimulus in question or a conditioned response to the same stimulus.


2018 ◽  
Vol 72 (2) ◽  
pp. 118-131 ◽  
Author(s):  
Ola Ahmed ◽  
Peter F Lovibond

Two experiments explored the role of verbalisable rules in generalisation of human differential fear conditioning with electric shock as the aversive stimulus. Two circles of different sizes served as conditioned stimuli (CS+ and CS–), before testing with a range of circle sizes. In Experiment 1, shock expectancy ratings followed a peak-shifted unimodal gradient, with maximum ratings at a test value further along the dimension from CS+ in the opposite direction to CS–. However, differentiable gradients were observed when participants were divided on the basis of the rules they reported using during the task (linear and similarity). Experiment 2 was designed to counter the contradictory feedback arising from extinction testing by removing the shock electrodes during the test phase. A more linear overall gradient was observed, and sub-groups defined by self-reported rules showed distinct gradients that were congruent with their rules. These results indicate that rule-based processes are influential in generalisation of conditioned fear along simple stimulus dimensions, and may help explain generalisation phenomena that have traditionally been attributed to automatic, similarity-based processes.


2010 ◽  
Author(s):  
W. M. Olango ◽  
S. M. Geranton ◽  
O. Moriarty ◽  
M. Roche ◽  
S. P. Hunt ◽  
...  

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