Potentiation of analgesic efficacy but not side effects: Co-administration of an α4β2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats

Receptor Agonist ◽

Analgesic Efficacy ◽

Experimental Models ◽

Allosteric Modulator ◽

A Novel Positive Allosteric Modulator of the 7 Neuronal Nicotinic Acetylcholine Receptor: In Vitro and In Vivo Characterization

Journal of Neuroscience ◽

10.1523/jneurosci.5269-04.2005 ◽

2005 ◽

Vol 25 (17) ◽

pp. 4396-4405 ◽

Cited By ~ 321

Author(s):

R. S. Hurst

Keyword(s):

Acetylcholine Receptor ◽

Allosteric Modulator ◽

Nicotinic Acetylcholine ◽

In Vivo Characterization

In Vitro Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.110.167072 ◽

2010 ◽

Vol 334 (3) ◽

pp. 863-874 ◽

Cited By ~ 40

Author(s):

John Malysz ◽

David J. Anderson ◽

Jens H. Grønlien ◽

Jianguo Ji ◽

William H. Bunnelle ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Pharmacological Characterization ◽

P4-310: Preclinical characterization of a selective alpha-7 neuronal nicotinic acetylcholine receptor agonist ABT-126: A novel therapeutic agent for the treatment of cognitive impairment in Alzheimer's disease and schizophrenia

Alzheimer s & Dementia ◽

10.1016/j.jalz.2013.05.1755 ◽

2013 ◽

Vol 9 ◽

pp. P817-P818 ◽

Cited By ~ 5

Author(s):

Robert Bitner ◽

David Anderson ◽

Karla Drescher ◽

Kathy Kohlhaas ◽

Halvard Gronlien ◽

...

Keyword(s):

Cognitive Impairment ◽

Acetylcholine Receptor ◽

Receptor Agonist ◽

Therapeutic Agent ◽

Nicotinic Acetylcholine ◽

Alpha 7 ◽

Novel Therapeutic

Faculty Opinions recommendation of Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.740011734.793585280 ◽

2021 ◽

Author(s):

Jean-Pierre Changeux

Keyword(s):

Acetylcholine Receptor ◽

Allosteric Modulator ◽

S59. Alpha-7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator Galantamine in Autism Spectrum Disorder

Biological Psychiatry ◽

10.1016/j.biopsych.2018.02.950 ◽

2018 ◽

Vol 83 (9) ◽

pp. S369-S370

Author(s):

Asif Rahman ◽

Robert Freedman ◽

Eric Hollander

Keyword(s):

Autism Spectrum Disorder ◽

Acetylcholine Receptor ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Allosteric Modulator ◽

Nicotinic Acetylcholine ◽

Alpha 7

Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure–Activity Relationship and Preclinical Characterization

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.9b01569 ◽

2019 ◽

Vol 63 (3) ◽

pp. 944-960 ◽

Cited By ~ 4

Author(s):

Neelima Sinha ◽

Navnath P. Karche ◽

Mahip Kalyan Verma ◽

Sameer S. Walunj ◽

Prashant B. Nigade ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Allosteric Modulator ◽

Nicotinic Acetylcholine ◽

Structure Activity

Characterization of RO5126946, a Novel α7 Nicotinic Acetylcholine Receptor–Positive Allosteric Modulator

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.113.210963 ◽

2014 ◽

Vol 350 (2) ◽

pp. 455-468 ◽

Cited By ~ 16

Author(s):

Sunil Sahdeo ◽

Tanya Wallace ◽

Ryoko Hirakawa ◽

Frederic Knoflach ◽

Daniel Bertrand ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Allosteric Modulator ◽

Discovery of 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm9003818 ◽

2009 ◽

Vol 52 (10) ◽

pp. 3377-3384 ◽

Cited By ~ 39

Author(s):

Ramin Faghih ◽

Sujatha M. Gopalakrishnan ◽

Jens Halvard Gronlien ◽

John Malysz ◽

Clark A. Briggs ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Allosteric Modulator ◽

PNU‐120596, a positive allosteric modulator of mammalian α7 nicotinic acetylcholine receptor, is a negative modulator of ligand‐gated chloride‐selective channels of the gastropod Lymnaea stagnalis

Journal of Neurochemistry ◽

10.1111/jnc.15020 ◽

2020 ◽

Vol 155 (3) ◽

pp. 274-284

Author(s):

Catherine A. Vulfius ◽

Dmitrii S. Lebedev ◽

Elena V. Kryukova ◽

Denis S. Kudryavtsev ◽

Sergey N. Kolbaev ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Lymnaea Stagnalis ◽

Allosteric Modulator ◽

Nicotinic Acetylcholine ◽

Negative Modulator

LL-00066471, a novel positive allosteric modulator of α7 nicotinic acetylcholine receptor ameliorates cognitive and sensorimotor gating deficits in animal models: Discovery and preclinical characterization

European Journal of Pharmacology ◽

10.1016/j.ejphar.2020.173685 ◽

2021 ◽

Vol 891 ◽

pp. 173685

Author(s):

Mahip K. Verma ◽

Rajan N. Goel ◽

Anand M. Bokare ◽

Manoj P. Dandekar ◽

Sarita Koul ◽

...

Keyword(s):

Animal Models ◽

Acetylcholine Receptor ◽

Sensorimotor Gating ◽

Allosteric Modulator ◽