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2022 ◽  
Vol 14 (10) ◽  
pp. 5187-5189
Noor Ali ◽  
Ibrahim S. Al-Jobouri ◽  
Widad M K Al-Ani

Evaluation of Iraqi medicinal plants is very crucial to help people avoid the use of herbs without prior knowledge which results in many side effects and sometimes even leads to death. The plant constituents vary according to season, weather and type of soil, therefore it is necessary to evaluate the chemical constituents and determine the time of collection of medicinal plants. In this research evaluation of the medicinal plant Calendula officinal grown in Iraq was performed by measuring the quantity of hyperoside found in the plant together with macroscopical and microscopical evaluation of the plant.

2022 ◽  
Vol 12 (3) ◽  
pp. 500-505
Mouzhang Huang ◽  
Limei Zeng ◽  
Rongping Zhu ◽  
Gongqun Chen ◽  
Haijian Wu ◽  

Doxorubicin (Dox) is a wide-spectrum drug to treat different kinds of cancers. However, in clinical practice, Dox usually showed untargeted distributions to the other organs, which can cause serious side effects, such as cardiotoxity. Herein, the formulation of Dox into nanoparticles is critical to enhance its distribution to tumors. Herein, we used polysaccharide, hyaluronic acid, to stabilize the Dox to form nano-precipitations (PD NPs) for the therapy of osteosarcoma. The PD NPs showed enhanced drug accumulation to tumor cells and realized better anticancer effects than free drugs.

2022 ◽  
Vol 27 (1) ◽  
pp. 1-35 ◽  
Nikolaos-Foivos Polychronou ◽  
Pierre-Henri Thevenon ◽  
Maxime Puys ◽  
Vincent Beroulle

With the advances in the field of the Internet of Things (IoT) and Industrial IoT (IIoT), these devices are increasingly used in daily life or industry. To reduce costs related to the time required to develop these devices, security features are usually not considered. This situation creates a major security concern. Many solutions have been proposed to protect IoT/IIoT against various attacks, most of which are based on attacks involving physical access. However, a new class of attacks has emerged targeting hardware vulnerabilities in the micro-architecture that do not require physical access. We present attacks based on micro-architectural hardware vulnerabilities and the side effects they produce in the system. In addition, we present security mechanisms that can be implemented to address some of these attacks. Most of the security mechanisms target a small set of attack vectors or a single specific attack vector. As many attack vectors exist, solutions must be found to protect against a wide variety of threats. This survey aims to inform designers about the side effects related to attacks and detection mechanisms that have been described in the literature. For this purpose, we present two tables listing and classifying the side effects and detection mechanisms based on the given criteria.

K Saranya ◽  
V Manivasagan ◽  
K Gopi ◽  
K Karthik ◽  

Cancer is an abnormal and uncontrolled growth of cells that spreads through cell division. There are different types of medicines available to treat cancers, but no drug is found to be fully effective and safe for humans. The major problem involved in the cancer treatments is the toxicity of the established drug and their side effects. Medicinal plants are used as folk medicines in Asian and African populations for thousands of years. 60% of the drugs for treating cancer are derived from plants. More than 3000 plants have anticancer activity. The present review aims at the study of a broad spectrum survey of plants having anticancer components for different type of cancers. This article consists of 364 medicinal plants and their different parts as potential Source of Anticancer Agents.

2022 ◽  
Vol 13 (1) ◽  
pp. 058-064
Barbara Fialho Carvalho Sampaio ◽  
Leandro Gregorut Lima ◽  
Marco Aurélio Silvério Neves ◽  
Carolina Paulette Neves ◽  
Heitor Franco de Andrade Júnior

Vaccines have saved millions of lives and reduced the severity of many infections, but today the reduction in vaccine coverage has been reflected in the resurgence of epidemics of mumps, whooping cough, measles and chickenpox. This has happened because many people do not recognize the effectiveness of vaccination and fear the side effects, in other words, the main concern is the safety of the vaccines. As a consequence, the greater responsibility of the individual and respect for his will can lead authorities to less vigorously promote the “duty of vaccination”, which is also a social duty. Unfortunately, however, the attitude of individuals is guided by their beliefs about health, which are often supported by an erroneous perception of risk arising from false news.

2022 ◽  
Vol 12 ◽  
Ping Huang ◽  
Haitong Wan ◽  
Chongyu Shao ◽  
Chang Li ◽  
Ling Zhang ◽  

Cerebral ischemic reperfusion injury (CI/RI) is a critical factor that leads to a poor prognosis in patients with ischemic stroke. It is an extremely complicated pathological process that is clinically characterized by high rates of disability and mortality. Current available treatments for CI/RI, including mechanical and drug therapies, are often accompanied by significant side effects. Therefore, it is necessary to discovery new strategies for treating CI/RI. Many studies confirm that Chinese herbal medicine (CHM) was used as a potential drug for treatment of CI/RI with the advantages of abundant resources, good efficacy, and few side effects. In this paper, we investigate the latest drug discoveries and advancements on CI/RI, make an overview of relevant CHM, and systematically summarize the pathophysiology of CI/RI. In addition, the protective effect and mechanism of related CHM, which includes extraction of single CHM and CHM formulation and preparation, are discussed. Moreover, an outline of the limitations of CHM and the challenges we faced are also presented. This review will be helpful for researchers further propelling the advancement of drugs and supplying more knowledge to support the application of previous discoveries in clinical drug applications against CI/RI.

2022 ◽  
Eagle Hemp CBD Gummies

2022 ◽  
Vol 19 (1) ◽  
pp. 37-42
Binod Kumar Yadav ◽  
Ram Chandra Choudhary ◽  
Gaurav Jung Shah ◽  
Saharoj Siddiqui

Introduction: The corona virus disease-19 pandemic is an ongoing global health crisis and the greatest challenge we have been facing right now in the most peculiar ways. It has caused huge loss of lives and has severely affected the global economy and financial markets. Vaccines are a new critical tool to fight this voracious battle. They have been released in several parts of the world. Although the safety and efficacy of these vaccines have been discussed, we know very little about the post-vaccination experience outside clinical trial situations. Adequate information about the effects of the vaccine can aware the public remove misconceptions and increase vaccine acceptability. Aims: To know the percentage of Covishield vaccine coverage and its adverse effects among the staffs of Nepalgunj Medical College. Methods: A descriptive cross-sectional study was conducted among the vaccinated 91 out of 116 staff members of Nepalgunj Medical College (NGMC), Baijanath Rural Municipality-1, Banke. Results: Out of 91 persons, 15.4%(14) developed headache, 20%(18) developed fever, and 8.7%(17) developed body aches. Of those who developed post-vaccination side effects 47%(16) of the persons were from age group 36-55years,17%(1) of them between age group 55-65 years, and none above 65 years developed fever. 20%(13) of total male and 35%(5) of total female developed fever within 96 hours after receiving first dose of Covishield AstraZeneca vaccine. Conclusion: Most of the study subjects reported milder side effects which lasted for less than 5 days. No casualties were reported. Local pain and swelling at the injection site, headache and fever were the most common side effects. The side effects were more common in younger individuals and women.

2022 ◽  
Vol 7 (2) ◽  
pp. 65-70
Gaurav Govil ◽  
Lavindra Tomar ◽  
Pawan Dhawan

The crisis of Covid-19 has shaken the world healthcare systems. The intensive care resources to manage the medical conditions associated with Covid-19 are consistently found to be inadequate with exploration and implementation of newer treatment avenues for an early recovery. Presently, the use of Tocilizumab (TCZ) in severe to critical affection of Covid-19 is being practiced as an off-label therapy. A narrative review of present knowledge regarding TCZ pharmacology, indications of its use, and potential side effects with clinical implications for an orthopedic surgeon is presented. The article discusses the clinicopathological factors required to be monitored during the perioperative management of an orthopedic patient who may have received TCZ for Covid-19 related illness. The implications of its usage should alert the orthopaedic surgeons for future management of their arthritic surgical patients. The commonly associated side effects and complications in the post-operative phase following an arthroplasty or any orthopaedic surgery are an area of concern and considerable uncertainty. In the post-Covid-19 recovery phase, when surgeons need to plan a surgical intervention then a thorough evaluation of their Covid-19 medical management history may be warranted. Practical guidelines for the management of arthritic surgical patients have been postulated. With an unregulated increased usage of TCZ during Covid-19 management, an orthopaedic surgeon should worry and needs to be aware of the possible consequences in the perioperative period for the post-surgery management. Future research to gain more insights will confirm the implied concerns.

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