Design, synthesis and biological evaluation of bitopic arylpiperazine-hexahydro-pyrazinoquinolines as preferential dopamine D3 receptor ligands

2018 ◽  
Vol 77 ◽  
pp. 125-135
Author(s):  
Benhua Zhou ◽  
Min Ji ◽  
Jin Cai
Keyword(s):  
Biological Evaluation ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Receptor Ligands ◽  
Design Synthesis ◽  
Dopamine D3 ◽  
Synthesis And Biological Evaluation

Design, Synthesis, and Evaluation of Indolebutylamines as a Novel Class of Selective Dopamine D3 Receptor Ligands

2013 ◽  
Vol 82 (3) ◽  
pp. 326-335 ◽  
Author(s):  
Peng Du ◽  
Lili Xu ◽  
Jiye Huang ◽  
Kunqian Yu ◽  
Rui Zhao ◽  
...  
Keyword(s):  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Receptor Ligands ◽  
Design Synthesis ◽  
Dopamine D3 ◽  
Selective Dopamine

Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D3 receptor ligands

2019 ◽  
Vol 29 (18) ◽  
pp. 2690-2694 ◽  
Author(s):  
Peng-Jen Chen ◽  
Michelle Taylor ◽  
Suzy A. Griffin ◽  
Armaghan Amani ◽  
Hamed Hayatshahi ◽  
...  
Keyword(s):  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Receptor Ligands ◽  
Design Synthesis ◽  
Dopamine D3 ◽  
Selective Dopamine

scholarly journals Design, Synthesis, And Evaluation of Functionalized Diamino-butylbenzamides As Selective Dopamine D3 Receptor Ligands

2021 ◽  
Author(s):  
Benjamin E Blass ◽  
Peng-Jen Chen ◽  
Michelle Taylor ◽  
Suzy A Griffin ◽  
John C Gordon ◽  
...  
Keyword(s):  
High Selectivity ◽  
Recreational Drugs ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Receptor Ligands ◽  
Potential Therapeutic Target ◽  
Design Synthesis ◽  
Medical Need ◽  
Dopamine D3 ◽  
Selective Dopamine

Abstract Substance use disorder remains a major, unmet medical need. Cocaine is one of the most commonly abused recreational drugs and in 2018, there were over 5.5 million current cocaine users. There are no approved therapies for the treatment of cocaine use disorder, but the D3 dopamine receptor has been identified as a potential therapeutic target. We have identified a series of functionalized diamino-butylbenzamides that are potent D3 binders with moderate to high selectivity for D3 over D2.

Design, synthesis and evaluation of bitopic arylpiperazinephenyl-1,2,4-oxadiazoles as preferential dopamine D3 receptor ligands

2016 ◽  
Vol 24 (2) ◽  
pp. 191-200 ◽  
Author(s):  
Yongkai Cao ◽  
Chengchun Min ◽  
Srijan Acharya ◽  
Kyeong-Man Kim ◽  
Seung Hoon Cheon
Keyword(s):  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Receptor Ligands ◽  
Design Synthesis ◽  
Dopamine D3

Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands

2008 ◽  
Vol 16 (7) ◽  
pp. 4035-4051 ◽  
Author(s):  
Kwang-Seop Song ◽  
Sung-Han Lee ◽  
Hyun Ji Chun ◽  
Jong Yup Kim ◽  
Myung Eun Jung ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Biological Evaluation ◽  
Receptor Ligands ◽  
Design Synthesis ◽  
Cb1 Cannabinoid Receptor ◽  
Synthesis And Biological Evaluation

ChemInform Abstract: Substituted Phenoxyalkylpiperazines as Dopamine D3 Receptor Ligands

ChemInform ◽  
2010 ◽  
Vol 32 (26) ◽  
pp. no-no
Author(s):  
I. Laszlovszky ◽  
T. Acs ◽  
B. Kiss ◽  
Gy. Domany
Keyword(s):  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Receptor Ligands ◽  
Dopamine D3

scholarly journals Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands

2015 ◽  
Vol 23 (14) ◽  
pp. 4000-4012 ◽  
Author(s):  
Thomas M. Keck ◽  
Ashwini K. Banala ◽  
Rachel D. Slack ◽  
Caitlin Burzynski ◽  
Alessandro Bonifazi ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Receptor Ligands ◽  
Dopamine D3
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