Design, synthesis and preliminary bioactivity evaluation of bitopic benzopyranomorpholine analogues as selective dopamine D3 receptor ligands as anti-drug addiction therapeutic agents

2021 ◽  
pp. 128269
Author(s):  
Jin Cai ◽  
Mingqi Huang ◽  
Yuhong Wang ◽  
XiXi Chen ◽  
Min Ji
Keyword(s):  
Drug Addiction ◽  
Therapeutic Agents ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Receptor Ligands ◽  
Design Synthesis ◽  
Dopamine D3 ◽  
Selective Dopamine

Design, Synthesis, and Evaluation of Indolebutylamines as a Novel Class of Selective Dopamine D3 Receptor Ligands

2013 ◽  
Vol 82 (3) ◽  
pp. 326-335 ◽  
Author(s):  
Peng Du ◽  
Lili Xu ◽  
Jiye Huang ◽  
Kunqian Yu ◽  
Rui Zhao ◽  
...  
Keyword(s):  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Receptor Ligands ◽  
Design Synthesis ◽  
Dopamine D3 ◽  
Selective Dopamine

Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D3 receptor ligands

2019 ◽  
Vol 29 (18) ◽  
pp. 2690-2694 ◽  
Author(s):  
Peng-Jen Chen ◽  
Michelle Taylor ◽  
Suzy A. Griffin ◽  
Armaghan Amani ◽  
Hamed Hayatshahi ◽  
...  
Keyword(s):  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Receptor Ligands ◽  
Design Synthesis ◽  
Dopamine D3 ◽  
Selective Dopamine

scholarly journals Design, Synthesis, And Evaluation of Functionalized Diamino-butylbenzamides As Selective Dopamine D3 Receptor Ligands

2021 ◽  
Author(s):  
Benjamin E Blass ◽  
Peng-Jen Chen ◽  
Michelle Taylor ◽  
Suzy A Griffin ◽  
John C Gordon ◽  
...  
Keyword(s):  
High Selectivity ◽  
Recreational Drugs ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Receptor Ligands ◽  
Potential Therapeutic Target ◽  
Design Synthesis ◽  
Medical Need ◽  
Dopamine D3 ◽  
Selective Dopamine

Abstract Substance use disorder remains a major, unmet medical need. Cocaine is one of the most commonly abused recreational drugs and in 2018, there were over 5.5 million current cocaine users. There are no approved therapies for the treatment of cocaine use disorder, but the D3 dopamine receptor has been identified as a potential therapeutic target. We have identified a series of functionalized diamino-butylbenzamides that are potent D3 binders with moderate to high selectivity for D3 over D2.

Dopamine D3 receptor ligands for drug addiction treatment

2014 ◽  
pp. 255-275 ◽  
Author(s):  
Bernard Le Foll ◽  
Ginetta Collo ◽  
Eugenii A. Rabiner ◽  
Isabelle Boileau ◽  
Emilio Merlo Pich ◽  
...  
Keyword(s):  
Drug Addiction ◽  
Addiction Treatment ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Receptor Ligands ◽  
Dopamine D3 ◽  
Drug Addiction Treatment

scholarly journals Design, synthesis, and evaluation of bitopic arylpiperazine-phthalimides as selective dopamine D3 receptor agonists

MedChemComm ◽  
2018 ◽  
Vol 9 (9) ◽  
pp. 1457-1465 ◽  
Author(s):  
Yongkai Cao ◽  
Ningning Sun ◽  
Jiumei Zhang ◽  
Zhiguo Liu ◽  
Yi-zhe Tang ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Neuropsychiatric Disorders ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Design Synthesis ◽  
Receptor Agonists ◽  
Dopamine D3 ◽  
Selective Dopamine

The dopamine D3 receptor (D3R) is a proven therapeutic target for the treatment of neurological and neuropsychiatric disorders.

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