Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators

2021 ◽  
pp. 105427
Author(s):  
Gehad Lotfy ◽  
Yasmine M. Abdel Aziz ◽  
Mohamed M. Said ◽  
El Sayed H. El Ashry ◽  
El Sayed H. El Tamany ◽  
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Molecular Hybridization ◽  
Next Generation ◽  
Design And Synthesis

Molecular hybridization based design and synthesis of new benzo[5,6]chromeno[2,3-b]-quinolin-13(14H)-one analogs as cholinesterase inhibitors

2021 ◽  
Author(s):  
Baswaraju Macha ◽  
Ravindra Kulkarni ◽  
Chandrakant Bagul ◽  
Anil Kumar Garige ◽  
Raghuramrao Akkinepally ◽  
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Cholinesterase Inhibitors ◽  
Molecular Hybridization ◽  
Design And Synthesis

Design and synthesis of novel carbazolo–thiazoles as potential anti-mycobacterial agents using a molecular hybridization approach

RSC Advances ◽  
2014 ◽  
Vol 4 (107) ◽  
pp. 62308-62320 ◽  
Author(s):  
Mahamadhanif S. Shaikh ◽  
Mahesh B. Palkar ◽  
Harun M. Patel ◽  
Rajesh A. Rane ◽  
Wesam S. Alwan ◽  
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Molecular Hybridization ◽  
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A series of novel carbazolo–thiazoles was synthesized and evaluated for in vitro anti-mycobacterial activity.

ChemInform Abstract: The Next Generation of MMP Inhibitors: Design and Synthesis

ChemInform ◽  
2010 ◽  
Vol 30 (51) ◽  
pp. no-no
Author(s):  
Biswanath De ◽  
Michael G. Natchus ◽  
Menyan Cheng ◽  
Stanislaw Pikul ◽  
Neil G. Almstead ◽  
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Design and Synthesis of 2-(Arylmethylideneamino) Isoindolines as New Potential Analgesic and Anti-Inflammatory Agents: A Molecular Hybridization Approach

2016 ◽  
Vol 22 (37) ◽  
pp. 5760-5766 ◽  
Author(s):  
Maryam Iman ◽  
Hamed Shafaroodi ◽  
Asghar Davood ◽  
Masoud Abedini ◽  
Pouyan Pishva ◽  
...  
Keyword(s):  
Molecular Hybridization ◽  
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The Next Generation of MMP Inhibitors: Design and Synthesis

1999 ◽  
Vol 878 (1 INHIBITION OF) ◽  
pp. 40-60 ◽  
Author(s):  
BISWANATH DE ◽  
MICHAEL G. NATCHUS ◽  
MENYAN CHENG ◽  
STANISLAW PIKUL ◽  
NEIL G. ALMSTEAD ◽  
...  
Keyword(s):  
Next Generation ◽  
Mmp Inhibitors ◽  
Design And Synthesis
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