scholarly journals Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: A new class of antiviral acyclic nucleoside phosphonates

2007 ◽  
Vol 15 (4) ◽  
pp. 1771-1779 ◽  
Author(s):  
Hyunah Choo ◽  
James R. Beadle ◽  
Youhoon Chong ◽  
Julissa Trahan ◽  
Karl Y. Hostetler
Keyword(s):  
New Class ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside

scholarly journals Inhibitory Activities of Three Classes of Acyclic Nucleoside Phosphonates against Murine Polyomavirus and Primate Simian Virus 40 Strains

2007 ◽  
Vol 51 (6) ◽  
pp. 2268-2273 ◽  
Author(s):  
Ilya Lebeau ◽  
Graciela Andrei ◽  
Marcela Krečmerová ◽  
Erik De Clercq ◽  
Antonin Holý ◽  
...  
Keyword(s):  
Simian Virus 40 ◽  
Simian Virus ◽  
New Class ◽  
Acyclic Nucleoside Phosphonates ◽  
Murine Polyomavirus ◽  
Inhibitory Activities ◽  
Acyclic Nucleoside

ABSTRACT Murine polyomavirus and simian virus 40 were used to evaluate the potencies of the compounds of three classes of acyclic nucleoside phosphonates: (i) the original HPMP (3-hydroxy-2-phosphonomethoxypropyl) and PME (2-phosphonomethoxyethyl) derivatives, (ii) the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidine (DAPy) derivatives, and (iii) a new class of HPMP derivatives containing a 5-azacytosine moiety. The last class showed the highest activities and selectivities against both polyomaviruses.

Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase by Acyclic Nucleoside Phosphonates: A New Class of Antimalarial Therapeutics

2009 ◽  
Vol 52 (14) ◽  
pp. 4391-4399 ◽  
Author(s):  
Dianne T. Keough ◽  
Dana Hocková ◽  
Antonín Holý ◽  
Lieve M. J. Naesens ◽  
Tina S. Skinner-Adams ◽  
...  
Keyword(s):  
New Class ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside ◽  
Hypoxanthine Guanine Phosphoribosyltransferase

Acyclic nucleoside phosphonates and human telomerase inhibition

2005 ◽  
Author(s):  
Miroslav Hájek ◽  
Naděžda Matulová ◽  
Ivan Votruba ◽  
Antonín Holý ◽  
Eva Tloušťová
Keyword(s):  
Telomerase Inhibition ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside ◽  
Human Telomerase

Tyrosine-based prodrugs of acyclic nucleoside phosphonates

2014 ◽  
Author(s):  
Tomáš Tichý ◽  
Karel Pomeisl ◽  
Marcela Krečmerová ◽  
Charles E. McKenna
Keyword(s):  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside
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