De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors

2011 ◽  
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Author(s):  
Cheng Jiang ◽  
Lei Yang ◽  
Wu-Tong Wu ◽  
Qing-Long Guo ◽  
Qi-Dong You
Keyword(s):  
De Novo ◽  
De Novo Design ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Kinesin Spindle Protein ◽  
Ksp Inhibitors ◽  
Synthesis And Biological Evaluation

Structure based design of selective SHP2 inhibitors by De novo design, synthesis and biological evaluation

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Wen-Shan Liu ◽  
Wen-Yan Jin ◽  
Liang Zhou ◽  
Xing-Hua Lu ◽  
Wei-Ya Li ◽  
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De Novo ◽  
De Novo Design ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPARγ ligands (I)

2006 ◽  
Vol 16 (22) ◽  
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Author(s):  
Xiaochun Dong ◽  
Zhenshan Zhang ◽  
Ren Wen ◽  
Jianhua Shen ◽  
Xu Shen ◽  
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De Novo ◽  
De Novo Design ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Design, Synthesis and Biological Evaluation of Hybrid Molecules Containing Conjugated Styryl Ketone and α-Bromoacryloyl Moieties

2012 ◽  
Vol 9 (2) ◽  
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Author(s):  
Romeo Romagnoli ◽  
Pier Giovanni Baraldi ◽  
Olga Cruz-Lopez ◽  
Maria Kimatrai Salvador ◽  
Delia Preti ◽  
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Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Hybrid Molecules ◽  
Synthesis And Biological Evaluation

Design, Synthesis and Biological Evaluation of Novel Aminosaccharide Derivatives of Combretastatin A-4

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Yan Tang ◽  
Zhewei Tu ◽  
Jing Sun ◽  
Xiong Zhu ◽  
Kun Liu ◽  
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Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
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