Design, synthesis, in vitro, and in silico studies of novel diarylimidazole-1,2,3-triazole hybrids as potent α-glucosidase inhibitors

2019 ◽  
Vol 27 (23) ◽  
pp. 115148 ◽  
Author(s):  
Mina Saeedi ◽  
Maryam Mohammadi-Khanaposhtani ◽  
Mohammad Sadegh Asgari ◽  
Nafiseh Eghbalnejad ◽  
Somaye Imanparast ◽  
...  
Keyword(s):  
In Silico ◽  
Design Synthesis ◽  
Glucosidase Inhibitors ◽  
In Silico Studies

scholarly journals Identification of Benzothiazole‒Rhodanine Derivatives as α-Amylase and α-Glucosidase Inhibitors: Design, Synthesis, In-silico and In-Vitro Analysis

2021 ◽  
Author(s):  
Revanasiddappa B C ◽  
Mahendra Gowdru Sriniv ◽  
Natasha Naval Aggarwal ◽  
Banylla Felicity Dkhar Gatphoh ◽  
Madan Kumar S ◽  
...  
Keyword(s):  
In Silico ◽  
Md Simulations ◽  
Accessible Surface Area ◽  
Solvent Accessible Surface Area ◽  
Antidiabetic Activity ◽  
Design Synthesis ◽  
Glucosidase Inhibitors ◽  
In Silico Studies ◽  
Vitro Analysis

Abstract In search for possible antidiabetic agents, a new series of Benzothiazole-Rhodanine derivatives (A1-10) have been synthesized and characterized by spectral data (IR, 1 H-NMR, C 13 -NMR, and HR-MS). All the designed compounds were subjected to In-silico studies using Schrodinger software and evaluated for In-vitro antidiabetic activity by α-amylase and α-glucosidase inhibitory assays. Among the tested compounds A5, A6 and A9 showed good activity when compared to the standard Acarbose. Also, Molecular dynamic (MD) simulations were conducted to evaluate the stability of the ligand-protein complex by the calculation of the root mean of square deviation (RMSD), root mean square fluctuation (RMSF), and solvent accessible surface area (SASA).

Design, Synthesis, In Vitro and In Silico Studies of Some Novel Thiazole-Dihyrofuran Derivatives as Aromatase Inhibitors

2021 ◽  
pp. 105123
Author(s):  
Derya Osmaniye ◽  
Şennur Görgülü ◽  
Begum Nurpelin Saglik ◽  
Serkan Levent ◽  
Yusuf Ozkay ◽  
...  
Keyword(s):  
Aromatase Inhibitors ◽  
In Silico ◽  
Design Synthesis ◽  
In Silico Studies

scholarly journals Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators

2021 ◽  
Vol 36 (1) ◽  
pp. 1370-1377
Author(s):  
Daniel A. S. Kitagawa ◽  
Rafael B. Rodrigues ◽  
Thiago N. Silva ◽  
Wellington V. dos Santos ◽  
Vinicius C. V. da Rocha ◽  
...  
Keyword(s):  
In Silico ◽  
Design Synthesis ◽  
In Vitro Evaluation ◽  
In Silico Studies ◽  
Acetylcholinesterase Reactivators

Design, Synthesis, In Vitro and In Silico Studies of Some Novel Triazoles as Anticancer Agents for Breast Cancer

2021 ◽  
pp. 131198
Author(s):  
Derya Osmaniye ◽  
Begum Nurpelin Saglik ◽  
Serkan Levent ◽  
Sinem Ilgın ◽  
Yusuf Ozkay ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Anticancer Agents ◽  
In Silico ◽  
Design Synthesis ◽  
In Silico Studies

scholarly journals Novel substituted oxadiazole - piperazine derivatives as potential MAO inhibitors: Design, synthesis, in vitro and in silico studies

2022 ◽  
Vol 26(1) (26(1)) ◽  
pp. 1037-1044
Author(s):  
Harun USLU ◽  
Begüm Nurpelin SAĞLIK ◽  
Derya OSMANİYE ◽  
Kadriye BENKLİ
Keyword(s):  
In Silico ◽  
Mao Inhibitors ◽  
Design Synthesis ◽  
Piperazine Derivatives ◽  
In Silico Studies

Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents

2020 ◽  
Vol 186 ◽  
pp. 111863 ◽  
Author(s):  
Muhammad Saeed Jan ◽  
Sajjad Ahmad ◽  
Fida Hussain ◽  
Ashfaq Ahmad ◽  
Fawad Mahmood ◽  
...  
Keyword(s):  
In Silico ◽  
Design Synthesis ◽  
In Silico Studies ◽  
Anti Inflammatory

New acridine-9-carboxamide linked to 1,2,3-triazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors: design, synthesis, in vitro, and in silico biological evaluations

2020 ◽  
Vol 29 (10) ◽  
pp. 1836-1845
Author(s):  
Nima Sepehri ◽  
Nafise Asemanipoor ◽  
Seyed Ali Mousavianfard ◽  
Seyedhamid Hoseini ◽  
Mohammad Ali Faramarzi ◽  
...  
Keyword(s):  
In Silico ◽  
Design Synthesis ◽  
Glucosidase Inhibitors

Design, synthesis, in vitro and in silico studies of 2, 3-diaryl benzofuran derivatives as antitubercular agents

2020 ◽  
Vol 99 ◽  
pp. 103784
Author(s):  
Balakishan Bhukya ◽  
Aparna Shukla ◽  
Vinita Chaturvedi ◽  
Priyanka Trivedi ◽  
Shailesh Kumar ◽  
...  
Keyword(s):  
In Silico ◽  
Antitubercular Agents ◽  
Design Synthesis ◽  
In Silico Studies

Design, Synthesis, In Vitro, and In Silico Studies of 1,2,4-Triazole-Piperazine Hybrid Derivatives as Potential MAO Inhibitors

2021 ◽  
pp. 105430
Author(s):  
Harun USLU ◽  
Derya OSMANİYE ◽  
Begüm Nurpelin SAĞLIK ◽  
Serkan LEVENT ◽  
Yusuf ÖZKAY ◽  
...  
Keyword(s):  
In Silico ◽  
Mao Inhibitors ◽  
Design Synthesis ◽  
In Silico Studies
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