Design, synthesis and biological evaluation of imidazole and oxazole fragments as HIV-1 integrase-LEDGF/p75 disruptors and inhibitors of microbial pathogens

Thompho J. Rashamuse; Angela T. Harrison; Salerwe Mosebi; Sandy van Vuuren; E. Mabel Coyanis; Moira L. Bode

doi:10.1016/j.bmc.2019.115210

Design, synthesis and biological evaluation of imidazole and oxazole fragments as HIV-1 integrase-LEDGF/p75 disruptors and inhibitors of microbial pathogens

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2019.115210 ◽

2020 ◽

Vol 28 (1) ◽

pp. 115210 ◽

Cited By ~ 4

Author(s):

Thompho J. Rashamuse ◽

Angela T. Harrison ◽

Salerwe Mosebi ◽

Sandy van Vuuren ◽

E. Mabel Coyanis ◽

...

Keyword(s):

Biological Evaluation ◽

Microbial Pathogens ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

Download Full-text

Arylazolylthioacetanilide. Part 11: Design, Synthesis and Biological Evaluation of 1,2,4-triazole Thioacetanilide Derivatives as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

Medicinal Chemistry ◽

10.2174/1573406411309070010 ◽

2013 ◽

Vol 9 (7) ◽

pp. 968-973 ◽

Cited By ~ 9

Author(s):

Zhenyu Li ◽

Yuan Cao ◽

Peng Zhan ◽

Christophe Pannecouque ◽

Jan Balzarini ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

Download Full-text

Design, synthesis, and biological evaluation of novel 5-Alkyl-6-Adamantylmethylpyrimidin-4(3H)-ones as HIV-1 non-nucleoside reverse-transcriptase inhibitors

Chemical Biology & Drug Design ◽

10.1111/cbdd.12765 ◽

2016 ◽

Vol 88 (3) ◽

pp. 380-385 ◽

Cited By ~ 2

Author(s):

Wenxin Li ◽

Boshi Huang ◽

Dongwei Kang ◽

Erik De Clercq ◽

Dirk Daelemans ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

Download Full-text

Design, Synthesis, and Biological Evaluation of Monopyrrolinone-Based HIV-1 Protease Inhibitors Possessing Augmented P2′ Side Chains.

ChemInform ◽

10.1002/chin.200619097 ◽

2006 ◽

Vol 37 (19) ◽

Author(s):

Amos B. III Smith ◽

et al. et al.

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Side Chains ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

Download Full-text

Design, Synthesis, and Biological Evaluation of Novel 2H-Pyran-2-one Derivatives as Potential HIV-1 Reverse Transcriptase Inhibitors

Archiv der Pharmazie ◽

10.1002/ardp.201400235 ◽

2014 ◽

Vol 348 (1) ◽

pp. 23-33 ◽

Cited By ~ 11

Author(s):

Andrea Defant ◽

Ines Mancini ◽

Rossella Tomazzolli ◽

Jan Balzarini

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

Download Full-text

Design, synthesis and biological evaluation of HIV-1 protease inhibitors with morpholine derivatives as P2 ligands in combination with cyclopropyl as P1′ ligand

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2020.127019 ◽

2020 ◽

Vol 30 (7) ◽

pp. 127019 ◽

Cited By ~ 1

Author(s):

Yue Dou ◽

Mei Zhu ◽

Biao Dong ◽

Ju-Xian Wang ◽

Guo-Ning Zhang ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Morpholine Derivatives ◽

Synthesis And Biological Evaluation ◽

Hiv 1

Download Full-text

Design, synthesis and biological evaluation of novel 5-((substituted quinolin-3-yl/1-naphthyl) methylene)-3-substituted imidazolidin-2,4-dione as HIV-1 fusion inhibitors

Bioorganic Chemistry ◽

10.1016/j.bioorg.2020.103782 ◽

2020 ◽

Vol 99 ◽

pp. 103782 ◽

Cited By ~ 6

Author(s):

Tarek S. Ibrahim ◽

Riham M. Bokhtia ◽

Amany M.M. AL-Mahmoudy ◽

Ehab S. Taher ◽

Mohammed A. AlAwadh ◽

...

Keyword(s):

Biological Evaluation ◽

Design Synthesis ◽

Fusion Inhibitors ◽

Synthesis And Biological Evaluation ◽

Hiv 1

Download Full-text

Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2018.12.039 ◽

2019 ◽

Vol 27 (3) ◽

pp. 447-456 ◽

Cited By ~ 3

Author(s):

Zhao Wang ◽

Zhao Yu ◽

Dongwei Kang ◽

Jian Zhang ◽

Ye Tian ◽

...

Keyword(s):

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

Download Full-text

Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.10.002 ◽

2011 ◽

Vol 19 (23) ◽

pp. 7093-7099 ◽

Cited By ~ 15

Author(s):

Shuang-Xi Gu ◽

Shi-Qiong Yang ◽

Qiu-Qin He ◽

Xiao-Dong Ma ◽

Fen-Er Chen ◽

...

Keyword(s):

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

Download Full-text

Design, synthesis and biological evaluation of heteroaryl diketohexenoic and diketobutanoic acids as HIV-1 integrase inhibitors endowed with antiretroviral activity

Il Farmaco ◽

10.1016/j.farmac.2005.03.008 ◽

2005 ◽

Vol 60 (5) ◽

pp. 409-417 ◽

Cited By ~ 20

Author(s):

R. Di Santo ◽

R. Costi ◽

M. Artico ◽

R. Ragno ◽

G. Greco ◽

...

Keyword(s):

Biological Evaluation ◽

Integrase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1 ◽

Antiretroviral Activity

Download Full-text

Design, synthesis, and biological evaluation of novel tricyclic HIV-1 integrase inhibitors by modification of its pyridine ring

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.05.018 ◽

2006 ◽

Vol 16 (15) ◽

pp. 3985-3988 ◽

Cited By ~ 33

Author(s):

Sammy E. Metobo ◽

Haolun Jin ◽

Manuel Tsiang ◽

Choung U. Kim

Keyword(s):

Pyridine Ring ◽

Biological Evaluation ◽

Integrase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

Download Full-text