Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives

Nucleoside Inhibitors ◽

Non-Nucleoside Inhibitors of the Hepatitis C Virus NS5B Polymerase: Discovery and Preliminary SAR of Benzimidazole Derivatives.

ChemInform ◽

10.1002/chin.200416125 ◽

2004 ◽

Vol 35 (16) ◽

Author(s):

Pierre L. Beaulieu ◽

et al. et al.

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Nucleoside Inhibitors ◽

Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review

Current Drug Targets ◽

10.2174/1389450117666151209123751 ◽

2016 ◽

Vol 17 (13) ◽

pp. 1560-1576 ◽

Cited By ~ 10

Author(s):

Yuanchao Xie ◽

Comfort Alicha Ogah ◽

Xiangrui Jiang ◽

Jianfeng Li ◽

Jingshan Shen

Keyword(s):

Systematic Review ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Nucleoside Inhibitors ◽

ChemInform Abstract: 3D QSAR and Molecular Docking Studies of Benzimidazole Derivatives as Hepatitis C Virus NS5B Polymerase Inhibitors.

ChemInform ◽

10.1002/chin.200818210 ◽

2008 ◽

Vol 39 (18) ◽

Author(s):

Pallav D. Patel ◽

Maulik R. Patel ◽

Neerja Kaushik-Basu ◽

Tanaji T. Talele

Keyword(s):

Molecular Docking ◽

Hepatitis C Virus ◽

Hepatitis C ◽

3D Qsar ◽

Docking Studies ◽

Molecular Docking Studies ◽

Polymerase Inhibitors ◽

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2003.12.032 ◽

2004 ◽

Vol 14 (4) ◽

pp. 967-971 ◽

Cited By ~ 70

Author(s):

Pierre L Beaulieu ◽

Michael Bös ◽

Yves Bousquet ◽

Patrick DeRoy ◽

Gulrez Fazal ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Amide Derivatives ◽

Nucleoside Inhibitors ◽

Binding Site Characterization and Resistance to a Class of Non-nucleoside Inhibitors of the Hepatitis C Virus NS5B Polymerase

Journal of Biological Chemistry ◽

10.1074/jbc.m506407200 ◽

2005 ◽

Vol 280 (47) ◽

pp. 39260-39267 ◽

Cited By ~ 94

Author(s):

George Kukolj ◽

Graham A. McGibbon ◽

Ginette McKercher ◽

Martin Marquis ◽

Sylvain Lefèbvre ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Binding Site ◽

Site Characterization ◽

Nucleoside Inhibitors ◽

Structural Basis for Resistance of the Genotype 2b Hepatitis C Virus NS5B Polymerase to Site A Non-Nucleoside Inhibitors

Journal of Molecular Biology ◽

10.1016/j.jmb.2009.06.012 ◽

2009 ◽

Vol 390 (5) ◽

pp. 1048-1059 ◽

Cited By ~ 13

Author(s):

Edwin H. Rydberg ◽

Antonella Cellucci ◽

Linda Bartholomew ◽

Marco Mattu ◽

Gaetano Barbato ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Structural Basis ◽

Nucleoside Inhibitors ◽

3D QSAR and Molecular Docking Studies of Benzimidazole Derivatives as Hepatitis C Virus NS5B Polymerase Inhibitors

Journal of Chemical Information and Modeling ◽

10.1021/ci700266z ◽

2007 ◽

Vol 48 (1) ◽

pp. 42-55 ◽

Cited By ~ 61

Author(s):

Pallav D. Patel ◽

Maulik R. Patel ◽

Neerja Kaushik-Basu ◽

Tanaji T. Talele

Keyword(s):

Molecular Docking ◽

Hepatitis C Virus ◽

Hepatitis C ◽

3D Qsar ◽

Docking Studies ◽

Molecular Docking Studies ◽

Polymerase Inhibitors ◽

CHAPTER 8. Design and Development of NS5B Polymerase Non‐nucleoside Inhibitors for the Treatment of Hepatitis C Virus Infection

Drug Discovery - Successful Strategies for the Discovery of Antiviral Drugs ◽

10.1039/9781849737814-00248 ◽

2013 ◽

pp. 248-294 ◽

Cited By ~ 5

Author(s):

Pierre L. Beaulieu

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Hepatitis C Virus Infection ◽

Design And Development ◽

Nucleoside Inhibitors ◽

Non-Nucleoside Inhibitors of the Hepatitis C Virus NS5B Polymerase: Discovery of Benzimidazole 5-Carboxylic Amide Derivatives with Low-Nanomolar Potency.

ChemInform ◽

10.1002/chin.200422239 ◽

2004 ◽

Vol 35 (22) ◽

Author(s):

Pierre L Beaulieu ◽

et al. et al.

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Amide Derivatives ◽

Nucleoside Inhibitors ◽

Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition

Journal of Molecular Biology ◽

10.1016/j.jmb.2006.05.074 ◽

2006 ◽

Vol 361 (1) ◽

pp. 33-45 ◽

Cited By ~ 60

Author(s):

Bichitra K. Biswal ◽

Meitian Wang ◽

Maia M. Cherney ◽

Laval Chan ◽

Constantin G. Yannopoulos ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Mechanism Of Inhibition ◽

Nucleoside Inhibitors ◽