Synthesis and biological evaluation of imidazole derivatives as novel NOP/ORL1 receptor antagonists: Exploration and optimization of alternative pyrazole structure

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.06.095 ◽

2009 ◽

Vol 19 (16) ◽

pp. 4611-4616 ◽

Author(s):

Yuichi Sugimoto ◽

Kensuke Kobayashi ◽

Masanori Asai ◽

Akio Ohno ◽

Koji Yamada ◽

...

Keyword(s):

Biological Evaluation ◽

Receptor Antagonists ◽

Imidazole Derivatives ◽

Orl1 Receptor ◽

Synthesis And Biological Evaluation

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ChemInform Abstract: Nonpeptide Angiotensin II Receptor Antagonists. Part 4. Synthesis and Biological Evaluation of 4-Acrylamide-1H-imidazole Derivatives.

10.1002/chin.199848121 ◽

2010 ◽

Vol 29 (48) ◽

pp. no-no

Author(s):

T. OKAZAKI ◽

T. WATANABE ◽

K. KIKUCHI ◽

A. SUGA ◽

M. SHIBASAKI ◽

...

Keyword(s):

Angiotensin Ii ◽

Biological Evaluation ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Imidazole Derivatives ◽

Synthesis And Biological Evaluation

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Studies on Nonpeptide Angiotensin II Receptor Antagonists. IV. Synthesis and Biological Evaluation of 4-Acrylamide-1H-imidazole Derivatives.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.46.973 ◽

1998 ◽

Vol 46 (6) ◽

pp. 973-981 ◽

Author(s):

Toshio OKAZAKI ◽

Toshihiro WATANABE ◽

Kazumi KIKUCHI ◽

Akira SUGA ◽

Masayuki SHIBASAKI ◽

...

Keyword(s):

Angiotensin Ii ◽

Biological Evaluation ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Imidazole Derivatives ◽

Synthesis And Biological Evaluation

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Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of σ1 Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)

Journal of Medicinal Chemistry ◽

10.1021/jm3007323 ◽

2012 ◽

Vol 55 (19) ◽

pp. 8211-8224 ◽

Author(s):

José Luis Díaz ◽

Rosa Cuberes ◽

Joana Berrocal ◽

Montserrat Contijoch ◽

Ute Christmann ◽

...

Keyword(s):

Biological Evaluation ◽

Receptor Antagonists ◽

Σ1 Receptor ◽

Synthesis And Biological Evaluation

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N-(2,7-Dimethyl-2-alkyl-2H-chromen-6-yl)sulfonamide derivatives as selective serotonin 5-HT6 receptor antagonists: design, synthesis, and biological evaluation

Journal of Molecular Structure ◽

10.1016/j.molstruc.2021.131417 ◽

2021 ◽

pp. 131417

Author(s):

Aizhan Abdildinova ◽

Young Chang Kim ◽

Gee-Hyung Lee ◽

Woo-Kyu Park ◽

Heeyeong Cho ◽

...

Keyword(s):

Biological Evaluation ◽

Selective Serotonin ◽

Receptor Antagonists ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of 4′-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.06.011 ◽

2012 ◽

Vol 20 (15) ◽

pp. 4661-4667 ◽

Author(s):

Renren Bai ◽

Zhen Wei ◽

Jie Liu ◽

Weijia Xie ◽

Hequan Yao ◽

...

Keyword(s):

Angiotensin Ii ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Endothelin A Receptor ◽

Endothelin A ◽

Synthesis And Biological Evaluation

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Synthesis and Biological Evaluation of Novel 1H-Benzo[d]imidazole Derivatives as Potential Anticancer Agents Targeting Human Topoisomerase I

ACS Omega ◽

10.1021/acsomega.1c05743 ◽

2022 ◽

Author(s):

Stuti Pandey ◽

Pragya Tripathi ◽

Palak Parashar ◽

Vikas Maurya ◽

Md. Zubbair Malik ◽

...

Keyword(s):

Anticancer Agents ◽

Topoisomerase I ◽

Biological Evaluation ◽

Imidazole Derivatives ◽

Synthesis And Biological Evaluation

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Design, synthesis, and biological evaluation of 2-(5-methyl-1H-pyrazol-1-yl) acetamide derivatives as androgen receptor antagonists

Medicinal Chemistry Research ◽

10.1007/s00044-019-02291-y ◽

2019 ◽

Vol 28 (3) ◽

pp. 380-386

Author(s):

Junze Dong ◽

Jingya Zhang ◽

Zilu Li ◽

Solomon Asnake ◽

Daoguang Zhang ◽

...

Keyword(s):

Androgen Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Androgen Receptor Antagonists

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Quantitative structure activity relationship (QSAR) studies on a series of imidazole derivatives as novel ORL1 receptor antagonists

Journal of Saudi Chemical Society ◽

10.1016/j.jscs.2011.04.014 ◽

2013 ◽

Vol 17 (3) ◽

pp. 321-328 ◽

Author(s):

A.K. Srivastava ◽

Neerja Shukla

Keyword(s):

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Receptor Antagonists ◽

Qsar Studies ◽

Imidazole Derivatives ◽

Orl1 Receptor ◽

Structure Activity

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Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y1 receptor antagonists

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.09.014 ◽

2018 ◽

Vol 158 ◽

pp. 302-310 ◽

Author(s):

Jingjing Peng ◽

Lifen Zhao ◽

Lanlan Wang ◽

Hui Chen ◽

Yunguang Qiu ◽

...

Keyword(s):

Biological Evaluation ◽

P2y1 Receptor ◽

Receptor Antagonists ◽

Urea Derivatives ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of N-hydroxy-aminobenzyloxyarylamide analogues as novel selective κ opioid receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2020.127236 ◽

2020 ◽

Vol 30 (13) ◽

pp. 127236

Author(s):

Guangchao He ◽

Qiao Song ◽

Junwei Wang ◽

Anhua Xu ◽

Kewen Peng ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Opioid Receptor Antagonists ◽

Synthesis And Biological Evaluation

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