Identification of N-acyl 4-(5-pyrimidine-2,4-dionyl)phenylalanine derivatives and their orally active prodrug esters as dual-acting alpha4–beta1 and alpha4–beta7 receptor antagonists

2013 ◽  
Vol 23 (4) ◽  
pp. 1026-1031 ◽  
Author(s):  
Achyutharao Sidduri ◽  
Jefferson W. Tilley ◽  
Jianping Lou ◽  
Nadine Tare ◽  
Gary Cavallo ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Orally Active ◽  
Alpha4 Beta7

scholarly journals Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists

2010 ◽  
Vol 1 (7) ◽  
pp. 316-320 ◽  
Author(s):  
Jian Jin ◽  
Ángel Morales-Ramos ◽  
Patrick Eidam ◽  
John Mecom ◽  
Yue Li ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Ep3 Receptor ◽  
Orally Active

Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core

2011 ◽  
Vol 21 (1) ◽  
pp. 76-81 ◽  
Author(s):  
Dong-Ming Shen ◽  
Edward J. Brady ◽  
Mari R. Candelore ◽  
Qing Dallas-Yang ◽  
Victor D.-H. Ding ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Glucagon Receptor ◽  
Orally Active

Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists

2005 ◽  
Vol 15 (20) ◽  
pp. 4564-4569 ◽  
Author(s):  
Dong-Ming Shen ◽  
Fengqi Zhang ◽  
Edward J. Brady ◽  
Mari Rios Candelore ◽  
Qing Dallas-Yang ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Glucagon Receptor ◽  
Orally Active

ChemInform Abstract: 5-Fluoro-2-methyl-N-[5-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-yl carbonyl)-2-pyridinyl]benzamide (CL-385004) and Analogues as Orally Active Arginine Vasopressin Receptor Antagonists.

ChemInform ◽  
2010 ◽  
Vol 30 (43) ◽  
pp. no-no
Author(s):  
Venkatesan Aranapakam ◽  
J. Donald Albright ◽  
George T. Grosu ◽  
Efren G. Delos Santos ◽  
Peter S. Chan ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Vasopressin Receptor ◽  
Receptor Antagonists ◽  
Orally Active

Discovery of potent, selective, orally active benzoxazepine-based Orexin-2 receptor antagonists

2011 ◽  
Vol 21 (21) ◽  
pp. 6414-6416 ◽  
Author(s):  
Tatsuhiko Fujimoto ◽  
Jun Kunitomo ◽  
Yoshihide Tomata ◽  
Keiji Nishiyama ◽  
Masato Nakashima ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Orally Active

Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity

2010 ◽  
Vol 20 (1) ◽  
pp. 184-188 ◽  
Author(s):  
Carsten Spanka ◽  
Ralf Glatthar ◽  
Sandrine Desrayaud ◽  
Markus Fendt ◽  
David Orain ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Mglu5 Receptor ◽  
Orally Active

scholarly journals Ethenesulfonamide Derivatives, a Novel Class of Orally Active Endothelin-A Receptor Antagonists

2001 ◽  
Vol 49 (5) ◽  
pp. 606-612 ◽  
Author(s):  
Hironori HARADA ◽  
Jun-ichi KAZAMI ◽  
Susumu WATANUKI ◽  
Ryuji TSUZUKI ◽  
Katsumi SUDOH ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Endothelin A Receptor ◽  
Endothelin A ◽  
Orally Active
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