Design of 2,5-Dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and Structure−Activity Relationships of a Series of Potent and Orally Active Corticotropin-Releasing Factor Receptor Antagonists

Chen; Keith M. Wilcoxen; Charles Q. Huang; Yun-Feng Xie; James R. McCarthy; Thomas R. Webb; Yun-Fei Zhu; John Saunders; Xin-Jun Liu; Ta-Kung Chen; Haig Bozigian; Dimitri E. Grigoriadis

doi:10.1021/jm040058e

Design of 2,5-Dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and Structure−Activity Relationships of a Series of Potent and Orally Active Corticotropin-Releasing Factor Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm040058e ◽

2004 ◽

Vol 47 (19) ◽

pp. 4787-4798 ◽

Cited By ~ 91

Author(s):

Chen ◽

Keith M. Wilcoxen ◽

Charles Q. Huang ◽

Yun-Feng Xie ◽

James R. McCarthy ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Synthesis and structure–activity relationships of 8-substituted-2-aryl-5-alkylaminoquinolines: Potent, orally active corticotropin-releasing factor-1 receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.09.028 ◽

2012 ◽

Vol 20 (22) ◽

pp. 6559-6578 ◽

Cited By ~ 7

Author(s):

Kunitoshi Takeda ◽

Taro Terauchi ◽

Minako Hashizume ◽

Kohdoh Shikata ◽

Ryota Taguchi ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Design, Synthesis, and Structure–Activity Relationships of Novel Pyrazolo[5,1-b]thiazole Derivatives as Potent and Orally Active Corticotropin-Releasing Factor 1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm300864p ◽

2012 ◽

Vol 55 (19) ◽

pp. 8450-8463 ◽

Cited By ~ 9

Author(s):

Yoshinori Takahashi ◽

Minako Hashizume ◽

Kogyoku Shin ◽

Taro Terauchi ◽

Kunitoshi Takeda ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Thiazole Derivatives ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Synthesis, structure–activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.05.117 ◽

2005 ◽

Vol 15 (17) ◽

pp. 3870-3873 ◽

Cited By ~ 14

Author(s):

Xiaojun Han ◽

Jodi A. Michne ◽

Sokhom S. Pin ◽

Kevin D. Burris ◽

Lynn A. Balanda ◽

...

Keyword(s):

Anxiolytic Activity ◽

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Corrigendum to “Design, synthesis, and structure–activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists” [Bioorg. Med. Chem. 22 (2014) 6071–6088]

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.04.042 ◽

2015 ◽

Vol 23 (13) ◽

pp. 3870

Author(s):

Yu Yoshida ◽

Taro Terauchi ◽

Yoshimitsu Naoe ◽

Yuji Kazuta ◽

Fumihiro Ozaki ◽

...

Keyword(s):

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Dihydropyridopyrazinones and Dihydropteridinones as Corticotropin-Releasing Factor-1 Receptor Antagonists: Structure−Activity Relationships and Computational Modeling

Journal of Medicinal Chemistry ◽

10.1021/jm0611410 ◽

2007 ◽

Vol 50 (9) ◽

pp. 2269-2272 ◽

Cited By ~ 4

Author(s):

Carolyn D. Dzierba ◽

Andrew J. Tebben ◽

Richard G. Wilde ◽

Amy G. Takvorian ◽

Maria Rafalski ◽

...

Keyword(s):

Computational Modeling ◽

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis, structure–activity relationships, and anticonvulsant activities of 2-amino-4H-pyrido[3,2-e][1,3]thiazin-4-one derivatives as orally active AMPA receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.02.033 ◽

2015 ◽

Vol 23 (8) ◽

pp. 1788-1799 ◽

Cited By ~ 5

Author(s):

Hiroshi Inami ◽

Jun-ichi Shishikura ◽

Tomoyuki Yasunaga ◽

Kazushige Ohno ◽

Hiroshi Yamashita ◽

...

Keyword(s):

Ampa Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Anticonvulsant Activities ◽

Orally Active

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Synthesis and structure–activity relationships of N3-pyridylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.01.129 ◽

2010 ◽

Vol 20 (6) ◽

pp. 1890-1894 ◽

Cited By ~ 15

Author(s):

Richard A. Hartz ◽

Vijay T. Ahuja ◽

William D. Schmitz ◽

Thaddeus F. Molski ◽

Gail K. Mattson ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Crf1 Receptor ◽

Structure Activity

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Rational Design, Synthesis, and Structure−Activity Relationships of Aryltriazoles as Novel Corticotropin-Releasing Factor-1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm049339c ◽

2005 ◽

Vol 48 (5) ◽

pp. 1540-1549 ◽

Cited By ~ 16

Author(s):

Richard F. Lowe ◽

Jodene Nelson ◽

Trunghau N. Dang ◽

Paul D. Crowe ◽

Anil Pahuja ◽

...

Keyword(s):

Rational Design ◽

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Design, synthesis, and structure–activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.08.034 ◽

2014 ◽

Vol 22 (21) ◽

pp. 6071-6088 ◽

Cited By ~ 12

Author(s):

Yu Yoshida ◽

Taro Terauchi ◽

Yoshimitsu Naoe ◽

Yuji Kazuta ◽

Fumihiro Ozaki ◽

...

Keyword(s):

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Synthesis and Structure–Activity Relationships of Pyrazolo[1,5-a]pyridine Derivatives: Potent and Orally Active Antagonists of Corticotropin-Releasing Factor 1 Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm300259r ◽

2012 ◽

Vol 55 (11) ◽

pp. 5255-5269 ◽

Cited By ~ 22

Author(s):

Yoshinori Takahashi ◽

Shigeki Hibi ◽

Yorihisa Hoshino ◽

Koichi Kikuchi ◽

Kogyoku Shin ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Pyridine Derivatives ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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