Hydroxymethyl bioisosteres of phenolic GluN2B-selective NMDA receptor antagonists: Design, synthesis and pharmacological evaluation

2018 ◽  
Vol 144 ◽  
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Author(s):  
Louisa Temme ◽  
Bastian Frehland ◽  
Dirk Schepmann ◽  
Dina Robaa ◽  
Wolfgang Sippl ◽  
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Nmda Receptor Antagonists ◽  
Receptor Antagonists ◽  
Design Synthesis ◽  
Pharmacological Evaluation

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ChemMedChem ◽  
2017 ◽  
Vol 12 (15) ◽  
pp. 1212-1222 ◽  
Author(s):  
Sandeep Gawaskar ◽  
Louisa Temme ◽  
Julian A. Schreiber ◽  
Dirk Schepmann ◽  
Alessandro Bonifazi ◽  
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Keyword(s):  
Nmda Receptor ◽  
Docking Studies ◽  
Nmda Receptor Antagonists ◽  
Receptor Antagonists ◽  
Design Synthesis ◽  
Pharmacological Evaluation

Synthesis and pharmacological evaluation of fluorinated benzo[7]annulen-7-amines as GluN2B-selective NMDA receptor antagonists

2019 ◽  
Vol 62 (8) ◽  
pp. 354-379 ◽  
Author(s):  
Simone Thum ◽  
Dirk Schepmann ◽  
Raquel F. Reinoso ◽  
Inés Alvarez ◽  
Simon M. Ametamey ◽  
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Keyword(s):  
Nmda Receptor ◽  
Nmda Receptor Antagonists ◽  
Receptor Antagonists ◽  
Pharmacological Evaluation

GluN2B-SelectiveN-Methyl-d-aspartate (NMDA) Receptor Antagonists Derived from 3-Benzazepines: Synthesis and Pharmacological Evaluation of Benzo[7]annulen-7-amines

ChemMedChem ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. 741-751 ◽  
Author(s):  
Andre Benner ◽  
Alessandro Bonifazi ◽  
Chikako Shirataki ◽  
Louisa Temme ◽  
Dirk Schepmann ◽  
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Nmda Receptor ◽  
Nmda Receptor Antagonists ◽  
Receptor Antagonists ◽  
Pharmacological Evaluation

Design, Synthesis, and Pharmacological Characterization of Novel, Potent NMDA Receptor Antagonists

2004 ◽  
Vol 47 (27) ◽  
pp. 6740-6748 ◽  
Author(s):  
Paola Conti ◽  
Marco De Amici ◽  
Giovanni Grazioso ◽  
Gabriella Roda ◽  
Federico F. Barberis Negra ◽  
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Nmda Receptor ◽  
Nmda Receptor Antagonists ◽  
Receptor Antagonists ◽  
Pharmacological Characterization ◽  
Design Synthesis

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ChemMedChem ◽  
2018 ◽  
Vol 13 (15) ◽  
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Author(s):  
Frederik Börgel ◽  
Marina Szermerski ◽  
Julian A. Schreiber ◽  
Louisa Temme ◽  
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Nmda Receptor ◽  
Nmda Receptor Antagonists ◽  
Receptor Antagonists ◽  
Enantiomerically Pure ◽  
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ChemMedChem ◽  
2010 ◽  
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pp. 687-695 ◽  
Author(s):  
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Bastian Frehland ◽  
Dirk Schepmann ◽  
Kai-Uwe Schmidtke ◽  
Thomas Winckler ◽  
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Nmda Receptor ◽  
Biological Evaluation ◽  
Nmda Receptor Antagonists ◽  
Receptor Antagonists ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation
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